Usp9x contributes to the development of sepsis-induced acute kidney injury by promoting inflammation and apoptosis in renal tubular epithelial cells via activation of the TLR4/nf-κb pathway

Usp9x contributes to the development of sepsis-induced acute kidney injury by promoting inflammation and apoptosis in renal tubular epithelial cells via activation of the TLR4/nf-κb pathway

As a pattern recognition receptor, Toll-like receptor 4 (TLR4) is crucial for the development and progression of acute kidney injury (AKI). This study aims to explore whether the deubiquitinase Usp9x influences the TLR4/NF-B pathway to cause sepsis-induced acute kidney injury (S-AKI). The model of A...

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Bibliographic Details
Main Authors: Shuhao Gong, Huawei Xiong, Yingchao Lei, Shipeng Huang, Yingdong Ouyang, Chunshui Cao, Ying Wang
Format: Article
Language:English
Published: Taylor & Francis Group 2024-12-01
Series:Renal Failure
Subjects:
Sepsis-induced acute kidney injury
ubiquitination modification
inflammation
apoptosis
Usp9x
TLR4/NF-κB
Online Access:https://www.tandfonline.com/doi/10.1080/0886022X.2024.2361089
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