Multifunctional scaffolds of β-tricalcium phosphate/bioactive glass coated with zinc oxide and copper oxide nanoparticles
Incorporating nanoparticles into scaffolds with regenerative potential is a promissory strategy to provide them with antimicrobial activity. Bioceramics, such as β-tricalcium phosphate (β-TCP) and bioactive glasses (BGs), stand out among synthetic materials for bone regeneration. In this context, we...
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| Format: | Article |
| Language: | English |
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Elsevier
2024-12-01
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| Series: | Nano Trends |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2666978124000291 |
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| author | Rodrigo L.M.S. Oliveira Lucas Barbosa Thaís C. Pereira Luísa R.M. Dona Thiago G. Tabuti Dayane B. Tada Eduardo R. Triboni Luciane D. de Oliveira Eliandra S. Trichês |
| author_facet | Rodrigo L.M.S. Oliveira Lucas Barbosa Thaís C. Pereira Luísa R.M. Dona Thiago G. Tabuti Dayane B. Tada Eduardo R. Triboni Luciane D. de Oliveira Eliandra S. Trichês |
| author_sort | Rodrigo L.M.S. Oliveira |
| collection | DOAJ |
| description | Incorporating nanoparticles into scaffolds with regenerative potential is a promissory strategy to provide them with antimicrobial activity. Bioceramics, such as β-tricalcium phosphate (β-TCP) and bioactive glasses (BGs), stand out among synthetic materials for bone regeneration. In this context, we report the incorporation of zinc oxide (ZnO) and copper oxide/copper nitrate (CuO/Cu2H3NO5) nanoparticles onto the surface of the β-TCP/BG scaffolds. This report addresses the physicochemical characterization of the scaffolds, their antimicrobial activity, and their response to MC3T3-E1 cells. Our findings show that the incorporation of both nanoparticles effectively inhibited S. aureus growth, including its biofilm formation. While the presence of the nanoparticles initially decreased MC3T3-E1 cell viability, cell proliferation improved with prolonged incubation. Overall, the β-TCP/BG_Zn and β-TCP/BG_Cu scaffolds showed an early antimicrobial response, aiding infection eradication, while also supporting cell proliferation over time. |
| format | Article |
| id | doaj-art-0683f181dc8442648e36ef4d05cc4263 |
| institution | OA Journals |
| issn | 2666-9781 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Nano Trends |
| spelling | doaj-art-0683f181dc8442648e36ef4d05cc42632025-08-20T02:35:47ZengElsevierNano Trends2666-97812024-12-01810005910.1016/j.nwnano.2024.100059Multifunctional scaffolds of β-tricalcium phosphate/bioactive glass coated with zinc oxide and copper oxide nanoparticlesRodrigo L.M.S. Oliveira0Lucas Barbosa1Thaís C. Pereira2Luísa R.M. Dona3Thiago G. Tabuti4Dayane B. Tada5Eduardo R. Triboni6Luciane D. de Oliveira7Eliandra S. Trichês8Bioceramics Laboratory, Instituto de Ciência e Tecnologia, Universidade Federal de São Paulo - UNIFESP, 12231-280, São José dos Campos, SP, BrazilBioceramics Laboratory, Instituto de Ciência e Tecnologia, Universidade Federal de São Paulo - UNIFESP, 12231-280, São José dos Campos, SP, BrazilInstituto de Ciência e Tecnologia, Universidade Estadual Paulista - UNESP, 12245-000, São José dos Campos, SP, BrazilLaboratory of Nanomaterials and Nanotoxicology, Instituto de Ciência e Tecnologia, Universidade Federal de São Paulo - UNIFESP, 12231-280, São José dos Campos, SP, BrazilLaboratory of Photochemistry and Functional Materials (FMF), Escola de Engenharia de Lorena, Universidade de São Paulo – EEL-USP, 12602-810, Lorena, SP, BrazilLaboratory of Nanomaterials and Nanotoxicology, Instituto de Ciência e Tecnologia, Universidade Federal de São Paulo - UNIFESP, 12231-280, São José dos Campos, SP, BrazilLaboratory of Photochemistry and Functional Materials (FMF), Escola de Engenharia de Lorena, Universidade de São Paulo – EEL-USP, 12602-810, Lorena, SP, BrazilInstituto de Ciência e Tecnologia, Universidade Estadual Paulista - UNESP, 12245-000, São José dos Campos, SP, BrazilBioceramics Laboratory, Instituto de Ciência e Tecnologia, Universidade Federal de São Paulo - UNIFESP, 12231-280, São José dos Campos, SP, Brazil; Corresponding author at: Eliandra de Sousa Trichês, 330 Talim Street, Vila Nair, Zip Code: 12231-280, São José dos Campos, SP, Brazil.Incorporating nanoparticles into scaffolds with regenerative potential is a promissory strategy to provide them with antimicrobial activity. Bioceramics, such as β-tricalcium phosphate (β-TCP) and bioactive glasses (BGs), stand out among synthetic materials for bone regeneration. In this context, we report the incorporation of zinc oxide (ZnO) and copper oxide/copper nitrate (CuO/Cu2H3NO5) nanoparticles onto the surface of the β-TCP/BG scaffolds. This report addresses the physicochemical characterization of the scaffolds, their antimicrobial activity, and their response to MC3T3-E1 cells. Our findings show that the incorporation of both nanoparticles effectively inhibited S. aureus growth, including its biofilm formation. While the presence of the nanoparticles initially decreased MC3T3-E1 cell viability, cell proliferation improved with prolonged incubation. Overall, the β-TCP/BG_Zn and β-TCP/BG_Cu scaffolds showed an early antimicrobial response, aiding infection eradication, while also supporting cell proliferation over time.http://www.sciencedirect.com/science/article/pii/S2666978124000291Multifunctional scaffoldsZinc oxide nanoparticlesCopper nanoparticlesAntimicrobial activityMC3T3-E1 cells3D printing |
| spellingShingle | Rodrigo L.M.S. Oliveira Lucas Barbosa Thaís C. Pereira Luísa R.M. Dona Thiago G. Tabuti Dayane B. Tada Eduardo R. Triboni Luciane D. de Oliveira Eliandra S. Trichês Multifunctional scaffolds of β-tricalcium phosphate/bioactive glass coated with zinc oxide and copper oxide nanoparticles Nano Trends Multifunctional scaffolds Zinc oxide nanoparticles Copper nanoparticles Antimicrobial activity MC3T3-E1 cells 3D printing |
| title | Multifunctional scaffolds of β-tricalcium phosphate/bioactive glass coated with zinc oxide and copper oxide nanoparticles |
| title_full | Multifunctional scaffolds of β-tricalcium phosphate/bioactive glass coated with zinc oxide and copper oxide nanoparticles |
| title_fullStr | Multifunctional scaffolds of β-tricalcium phosphate/bioactive glass coated with zinc oxide and copper oxide nanoparticles |
| title_full_unstemmed | Multifunctional scaffolds of β-tricalcium phosphate/bioactive glass coated with zinc oxide and copper oxide nanoparticles |
| title_short | Multifunctional scaffolds of β-tricalcium phosphate/bioactive glass coated with zinc oxide and copper oxide nanoparticles |
| title_sort | multifunctional scaffolds of β tricalcium phosphate bioactive glass coated with zinc oxide and copper oxide nanoparticles |
| topic | Multifunctional scaffolds Zinc oxide nanoparticles Copper nanoparticles Antimicrobial activity MC3T3-E1 cells 3D printing |
| url | http://www.sciencedirect.com/science/article/pii/S2666978124000291 |
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