Dasatinib for treatment of CAR T-cell therapy-related complications

Dasatinib for treatment of CAR T-cell therapy-related complications

Cytokine release syndrome (CRS) and immune effector cell-associated neurotoxicity syndrome (ICANS) are severe, potentially life-threatening side effects of chimeric antigen receptor T-cell (CAR T) therapy caused by the release of cytokines by proliferating and activated CAR T-cells. Current mainstay...

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Bibliographic Details
Main Authors: Jakob R Passweg, Dominik Heim, Katharina Baur, Astrid Beerlage, Anna S Poerings, Bastian Kopp, Michael Medinger, Jan C Dirks, Andreas Holbro
Format: Article
Language:English
Published: BMJ Publishing Group 2022-12-01
Series:Journal for ImmunoTherapy of Cancer
Online Access:https://jitc.bmj.com/content/10/12/e005956.full
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