Quantitative computed tomography coronary angiography in patients with acute myocardial infarction: association with cardiac biomarkers
Aim. To study quantitative parameters of coronary atherosclerosis, according to computed tomography coronary angiography (CTCA), and to identify their association with the level of cardiac biomarkers in patients with acute myocardial infarction (MI).Material and methods. The study included patients...
Saved in:
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | Russian |
| Published: |
«FIRMA «SILICEA» LLC
2025-01-01
|
| Series: | Российский кардиологический журнал |
| Subjects: | |
| Online Access: | https://russjcardiol.elpub.ru/jour/article/view/6101 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849774985451667456 |
|---|---|
| author | A. S. Dasheeva D. A. Vorobyeva T. E. Suslova A. N. Maltseva A. V. Mochula V. V. Ryabov O. V. Mochula K. V. Zavadovsky |
| author_facet | A. S. Dasheeva D. A. Vorobyeva T. E. Suslova A. N. Maltseva A. V. Mochula V. V. Ryabov O. V. Mochula K. V. Zavadovsky |
| author_sort | A. S. Dasheeva |
| collection | DOAJ |
| description | Aim. To study quantitative parameters of coronary atherosclerosis, according to computed tomography coronary angiography (CTCA), and to identify their association with the level of cardiac biomarkers in patients with acute myocardial infarction (MI).Material and methods. The study included patients with newly diagnosed MI. Depending on the coronary artery (CA) stenosis, two groups were formed: 1) MI with obstructive CA ≥50% (MICAD); 2) MI with non-obstructive CA <50% (MINOCA). All patients were assessed for cardiac biomarkers and underwent CTCA.Results. The study included 31 patients as follows: MINOCA group consisted of 10 patients (5 men aged 68 (57; 79) years); MICAD group — 21 patients (13 men aged 62 (56; 68) years). When analyzing cardiac biomarker levels, a significant increase in cardiac troponin I (cTnI) levels was noted on the 4th (p=0,04) and on the 7th day (p=0,0009) in MICAD patients. A significant predominance of the volume (p=0,01) and burden (p=0,004) of low-density plaques was revealed in the MICAD group compared to MINOCA. In addition, MICAD patients had significantly increased values of the total atherosclerotic burden (p=0,01) and the total burden of the soft tissue component of plaques (p=0,04). A significant correlation was found between the plaque volume with cTnI on day 7 (ρ=0,52, p<0,05) and the plaque burden with cTnI on day 7 (ρ=0,43, p<0,05).Conclusion. According to CTCA, the soft tissue component of plaques is associated with coronary atherosclerosis severity and myocardial damage in patients with MI. Soft tissue burden is a predictor of more severe myocardial damage, according to the cardiac biomarker data. |
| format | Article |
| id | doaj-art-067ffa0c07434ebe995603351f04329d |
| institution | DOAJ |
| issn | 1560-4071 2618-7620 |
| language | Russian |
| publishDate | 2025-01-01 |
| publisher | «FIRMA «SILICEA» LLC |
| record_format | Article |
| series | Российский кардиологический журнал |
| spelling | doaj-art-067ffa0c07434ebe995603351f04329d2025-08-20T03:01:34Zrus«FIRMA «SILICEA» LLCРоссийский кардиологический журнал1560-40712618-76202025-01-01291210.15829/1560-4071-2024-61014284Quantitative computed tomography coronary angiography in patients with acute myocardial infarction: association with cardiac biomarkersA. S. Dasheeva0D. A. Vorobyeva1T. E. Suslova2A. N. Maltseva3A. V. Mochula4V. V. Ryabov5O. V. Mochula6K. V. Zavadovsky7Cardiology Research Institute, Tomsk National Research Medical CenterCardiology Research Institute, Tomsk National Research Medical CenterCardiology Research Institute, Tomsk National Research Medical CenterCardiology Research Institute, Tomsk National Research Medical CenterCardiology Research Institute, Tomsk National Research Medical CenterCardiology Research Institute, Tomsk National Research Medical CenterCardiology Research Institute, Tomsk National Research Medical CenterCardiology Research Institute, Tomsk National Research Medical CenterAim. To study quantitative parameters of coronary atherosclerosis, according to computed tomography coronary angiography (CTCA), and to identify their association with the level of cardiac biomarkers in patients with acute myocardial infarction (MI).Material and methods. The study included patients with newly diagnosed MI. Depending on the coronary artery (CA) stenosis, two groups were formed: 1) MI with obstructive CA ≥50% (MICAD); 2) MI with non-obstructive CA <50% (MINOCA). All patients were assessed for cardiac biomarkers and underwent CTCA.Results. The study included 31 patients as follows: MINOCA group consisted of 10 patients (5 men aged 68 (57; 79) years); MICAD group — 21 patients (13 men aged 62 (56; 68) years). When analyzing cardiac biomarker levels, a significant increase in cardiac troponin I (cTnI) levels was noted on the 4th (p=0,04) and on the 7th day (p=0,0009) in MICAD patients. A significant predominance of the volume (p=0,01) and burden (p=0,004) of low-density plaques was revealed in the MICAD group compared to MINOCA. In addition, MICAD patients had significantly increased values of the total atherosclerotic burden (p=0,01) and the total burden of the soft tissue component of plaques (p=0,04). A significant correlation was found between the plaque volume with cTnI on day 7 (ρ=0,52, p<0,05) and the plaque burden with cTnI on day 7 (ρ=0,43, p<0,05).Conclusion. According to CTCA, the soft tissue component of plaques is associated with coronary atherosclerosis severity and myocardial damage in patients with MI. Soft tissue burden is a predictor of more severe myocardial damage, according to the cardiac biomarker data.https://russjcardiol.elpub.ru/jour/article/view/6101coronary artery diseaseacute myocardial infarctionquantitative computed tomography coronary angiographycoronary atherosclerosisatherosclerotic burdencardiac biochemical markers |
| spellingShingle | A. S. Dasheeva D. A. Vorobyeva T. E. Suslova A. N. Maltseva A. V. Mochula V. V. Ryabov O. V. Mochula K. V. Zavadovsky Quantitative computed tomography coronary angiography in patients with acute myocardial infarction: association with cardiac biomarkers Российский кардиологический журнал coronary artery disease acute myocardial infarction quantitative computed tomography coronary angiography coronary atherosclerosis atherosclerotic burden cardiac biochemical markers |
| title | Quantitative computed tomography coronary angiography in patients with acute myocardial infarction: association with cardiac biomarkers |
| title_full | Quantitative computed tomography coronary angiography in patients with acute myocardial infarction: association with cardiac biomarkers |
| title_fullStr | Quantitative computed tomography coronary angiography in patients with acute myocardial infarction: association with cardiac biomarkers |
| title_full_unstemmed | Quantitative computed tomography coronary angiography in patients with acute myocardial infarction: association with cardiac biomarkers |
| title_short | Quantitative computed tomography coronary angiography in patients with acute myocardial infarction: association with cardiac biomarkers |
| title_sort | quantitative computed tomography coronary angiography in patients with acute myocardial infarction association with cardiac biomarkers |
| topic | coronary artery disease acute myocardial infarction quantitative computed tomography coronary angiography coronary atherosclerosis atherosclerotic burden cardiac biochemical markers |
| url | https://russjcardiol.elpub.ru/jour/article/view/6101 |
| work_keys_str_mv | AT asdasheeva quantitativecomputedtomographycoronaryangiographyinpatientswithacutemyocardialinfarctionassociationwithcardiacbiomarkers AT davorobyeva quantitativecomputedtomographycoronaryangiographyinpatientswithacutemyocardialinfarctionassociationwithcardiacbiomarkers AT tesuslova quantitativecomputedtomographycoronaryangiographyinpatientswithacutemyocardialinfarctionassociationwithcardiacbiomarkers AT anmaltseva quantitativecomputedtomographycoronaryangiographyinpatientswithacutemyocardialinfarctionassociationwithcardiacbiomarkers AT avmochula quantitativecomputedtomographycoronaryangiographyinpatientswithacutemyocardialinfarctionassociationwithcardiacbiomarkers AT vvryabov quantitativecomputedtomographycoronaryangiographyinpatientswithacutemyocardialinfarctionassociationwithcardiacbiomarkers AT ovmochula quantitativecomputedtomographycoronaryangiographyinpatientswithacutemyocardialinfarctionassociationwithcardiacbiomarkers AT kvzavadovsky quantitativecomputedtomographycoronaryangiographyinpatientswithacutemyocardialinfarctionassociationwithcardiacbiomarkers |