A Rare Case of Vancomycin-Induced Linear Immunoglobulin A Bullous Dermatosis
Linear IgA bullous dermatosis (LABD) is an autoimmune vesiculobullous disease, which is typically idiopathic but can also rarely be caused by medications or infections. Vancomycin is the most common drug associated with LABD. Lesions typically appear 24 hours to 15 days after the first dose of vanco...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2017-01-01
|
| Series: | Case Reports in Dermatological Medicine |
| Online Access: | http://dx.doi.org/10.1155/2017/7318305 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850231015209959424 |
|---|---|
| author | Pinky Jha Kurtis Swanson Jeremiah Stromich Basia M. Michalski Edit Olasz |
| author_facet | Pinky Jha Kurtis Swanson Jeremiah Stromich Basia M. Michalski Edit Olasz |
| author_sort | Pinky Jha |
| collection | DOAJ |
| description | Linear IgA bullous dermatosis (LABD) is an autoimmune vesiculobullous disease, which is typically idiopathic but can also rarely be caused by medications or infections. Vancomycin is the most common drug associated with LABD. Lesions typically appear 24 hours to 15 days after the first dose of vancomycin. It is best characterized pathologically by subepidermal bulla (blister) formation with linear IgA deposition at the dermoepidermal junction. Here we report an 86-year-old male with a history of left knee osteoarthritis who underwent a left knee arthroplasty and subsequently developed a prosthetic joint infection. This infection was treated with intravenous vancomycin as well as placement of a vancomycin impregnated joint spacer. Five days following initiation of antibiotic therapy, he presented with a vesiculobullous eruption on an erythematous base over his trunk, extremities, and oral mucosa. The eruption resolved completely when intravenous vancomycin was discontinued and colchicine treatment was begun. Curiously, complete resolution occurred despite the presence of the vancomycin containing joint spacer. The diagnosis of vancomycin-induced linear IgA bullous dermatosis was made based on characteristic clinical and histopathologic presentations. |
| format | Article |
| id | doaj-art-067f1f9b343d4b49b0407d46983539db |
| institution | OA Journals |
| issn | 2090-6463 2090-6471 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Dermatological Medicine |
| spelling | doaj-art-067f1f9b343d4b49b0407d46983539db2025-08-20T02:03:40ZengWileyCase Reports in Dermatological Medicine2090-64632090-64712017-01-01201710.1155/2017/73183057318305A Rare Case of Vancomycin-Induced Linear Immunoglobulin A Bullous DermatosisPinky Jha0Kurtis Swanson1Jeremiah Stromich2Basia M. Michalski3Edit Olasz4Section of Hospital Medicine, Division of General Internal Medicine, Medical College of Wisconsin, Milwaukee, WI, USAMedical College of Wisconsin, Milwaukee, WI, USAMedical College of Wisconsin, Milwaukee, WI, USAMedical College of Wisconsin, Milwaukee, WI, USADepartment of Dermatology, Medical College of Wisconsin, Milwaukee, WI, USALinear IgA bullous dermatosis (LABD) is an autoimmune vesiculobullous disease, which is typically idiopathic but can also rarely be caused by medications or infections. Vancomycin is the most common drug associated with LABD. Lesions typically appear 24 hours to 15 days after the first dose of vancomycin. It is best characterized pathologically by subepidermal bulla (blister) formation with linear IgA deposition at the dermoepidermal junction. Here we report an 86-year-old male with a history of left knee osteoarthritis who underwent a left knee arthroplasty and subsequently developed a prosthetic joint infection. This infection was treated with intravenous vancomycin as well as placement of a vancomycin impregnated joint spacer. Five days following initiation of antibiotic therapy, he presented with a vesiculobullous eruption on an erythematous base over his trunk, extremities, and oral mucosa. The eruption resolved completely when intravenous vancomycin was discontinued and colchicine treatment was begun. Curiously, complete resolution occurred despite the presence of the vancomycin containing joint spacer. The diagnosis of vancomycin-induced linear IgA bullous dermatosis was made based on characteristic clinical and histopathologic presentations.http://dx.doi.org/10.1155/2017/7318305 |
| spellingShingle | Pinky Jha Kurtis Swanson Jeremiah Stromich Basia M. Michalski Edit Olasz A Rare Case of Vancomycin-Induced Linear Immunoglobulin A Bullous Dermatosis Case Reports in Dermatological Medicine |
| title | A Rare Case of Vancomycin-Induced Linear Immunoglobulin A Bullous Dermatosis |
| title_full | A Rare Case of Vancomycin-Induced Linear Immunoglobulin A Bullous Dermatosis |
| title_fullStr | A Rare Case of Vancomycin-Induced Linear Immunoglobulin A Bullous Dermatosis |
| title_full_unstemmed | A Rare Case of Vancomycin-Induced Linear Immunoglobulin A Bullous Dermatosis |
| title_short | A Rare Case of Vancomycin-Induced Linear Immunoglobulin A Bullous Dermatosis |
| title_sort | rare case of vancomycin induced linear immunoglobulin a bullous dermatosis |
| url | http://dx.doi.org/10.1155/2017/7318305 |
| work_keys_str_mv | AT pinkyjha ararecaseofvancomycininducedlinearimmunoglobulinabullousdermatosis AT kurtisswanson ararecaseofvancomycininducedlinearimmunoglobulinabullousdermatosis AT jeremiahstromich ararecaseofvancomycininducedlinearimmunoglobulinabullousdermatosis AT basiammichalski ararecaseofvancomycininducedlinearimmunoglobulinabullousdermatosis AT editolasz ararecaseofvancomycininducedlinearimmunoglobulinabullousdermatosis AT pinkyjha rarecaseofvancomycininducedlinearimmunoglobulinabullousdermatosis AT kurtisswanson rarecaseofvancomycininducedlinearimmunoglobulinabullousdermatosis AT jeremiahstromich rarecaseofvancomycininducedlinearimmunoglobulinabullousdermatosis AT basiammichalski rarecaseofvancomycininducedlinearimmunoglobulinabullousdermatosis AT editolasz rarecaseofvancomycininducedlinearimmunoglobulinabullousdermatosis |