Association between Helicobacter pylori Infection and Chronic Urticaria: A Meta-Analysis
Background. Some studies have shown the possible involvement of Helicobacter pylori (H. pylori) infection in chronic urticaria, but the relationship remains controversial. The aim of this meta-analysis was to quantitatively assess the association between H. pylori infection and chronic urticaria. Me...
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | Gastroenterology Research and Practice |
| Online Access: | http://dx.doi.org/10.1155/2015/486974 |
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| _version_ | 1832555091411861504 |
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| author | Huiyuan Gu Lin Li Min Gu Guoxin Zhang |
| author_facet | Huiyuan Gu Lin Li Min Gu Guoxin Zhang |
| author_sort | Huiyuan Gu |
| collection | DOAJ |
| description | Background. Some studies have shown the possible involvement of Helicobacter pylori (H. pylori) infection in chronic urticaria, but the relationship remains controversial. The aim of this meta-analysis was to quantitatively assess the association between H. pylori infection and chronic urticaria. Methods. Observational studies comparing the prevalence of H. pylori infection in patients with chronic urticaria and control subjects were identified through a systematic search in MEDLINE and EMBASE up to July 2014. H. pylori infection was confirmed by serological or nonserological tests. For subgroup analyses, studies were separated by region, publication year, and H. pylori detection method to screen the potential factors resulting in heterogeneity. Results. 16 studies involving 965 CU cases and 1235 controls were included. Overall, the prevalence of H. pylori infection was higher in urticarial patients than in controls (OR = 1.66; 95% CI: 1.12–2.45; P=0.01). This result persisted in subanalysis of nine high-quality studies (OR = 1.36; 95% CI: 1.03–1.80; P=0.03). Subgroup analysis showed that detection method of H. pylori is also a potential influential factor for the overall results. Conclusions. Our present meta-analysis suggests that H. pylori infection is significantly, though weakly, associated with an increased risk of chronic urticaria. |
| format | Article |
| id | doaj-art-067c06c769e04e46aa8d156067f4e1d3 |
| institution | Kabale University |
| issn | 1687-6121 1687-630X |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Gastroenterology Research and Practice |
| spelling | doaj-art-067c06c769e04e46aa8d156067f4e1d32025-02-03T05:49:31ZengWileyGastroenterology Research and Practice1687-61211687-630X2015-01-01201510.1155/2015/486974486974Association between Helicobacter pylori Infection and Chronic Urticaria: A Meta-AnalysisHuiyuan Gu0Lin Li1Min Gu2Guoxin Zhang3Department of Gastroenterology, First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, ChinaDepartment of Gastroenterology, First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, ChinaDepartment of Pediatrics, Changzhou Children’s Hospital, Changzhou, Jiangsu 213003, ChinaDepartment of Gastroenterology, First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, ChinaBackground. Some studies have shown the possible involvement of Helicobacter pylori (H. pylori) infection in chronic urticaria, but the relationship remains controversial. The aim of this meta-analysis was to quantitatively assess the association between H. pylori infection and chronic urticaria. Methods. Observational studies comparing the prevalence of H. pylori infection in patients with chronic urticaria and control subjects were identified through a systematic search in MEDLINE and EMBASE up to July 2014. H. pylori infection was confirmed by serological or nonserological tests. For subgroup analyses, studies were separated by region, publication year, and H. pylori detection method to screen the potential factors resulting in heterogeneity. Results. 16 studies involving 965 CU cases and 1235 controls were included. Overall, the prevalence of H. pylori infection was higher in urticarial patients than in controls (OR = 1.66; 95% CI: 1.12–2.45; P=0.01). This result persisted in subanalysis of nine high-quality studies (OR = 1.36; 95% CI: 1.03–1.80; P=0.03). Subgroup analysis showed that detection method of H. pylori is also a potential influential factor for the overall results. Conclusions. Our present meta-analysis suggests that H. pylori infection is significantly, though weakly, associated with an increased risk of chronic urticaria.http://dx.doi.org/10.1155/2015/486974 |
| spellingShingle | Huiyuan Gu Lin Li Min Gu Guoxin Zhang Association between Helicobacter pylori Infection and Chronic Urticaria: A Meta-Analysis Gastroenterology Research and Practice |
| title | Association between Helicobacter pylori Infection and Chronic Urticaria: A Meta-Analysis |
| title_full | Association between Helicobacter pylori Infection and Chronic Urticaria: A Meta-Analysis |
| title_fullStr | Association between Helicobacter pylori Infection and Chronic Urticaria: A Meta-Analysis |
| title_full_unstemmed | Association between Helicobacter pylori Infection and Chronic Urticaria: A Meta-Analysis |
| title_short | Association between Helicobacter pylori Infection and Chronic Urticaria: A Meta-Analysis |
| title_sort | association between helicobacter pylori infection and chronic urticaria a meta analysis |
| url | http://dx.doi.org/10.1155/2015/486974 |
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