Advantages of Broad-Spectrum Influenza mRNA Vaccines and Their Impact on Pulmonary Influenza
Influenza poses a significant global health challenge due to its rapid mutation and antigenic variability, which often leads to seasonal epidemics and frequent outbreaks. Traditional vaccines struggle to offer comprehensive protection because of mismatches with circulating viral strains. The develop...
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MDPI AG
2024-12-01
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| Series: | Vaccines |
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| Online Access: | https://www.mdpi.com/2076-393X/12/12/1382 |
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| author | Ziqi Cheng Junfeng Ma Chenyan Zhao |
| author_facet | Ziqi Cheng Junfeng Ma Chenyan Zhao |
| author_sort | Ziqi Cheng |
| collection | DOAJ |
| description | Influenza poses a significant global health challenge due to its rapid mutation and antigenic variability, which often leads to seasonal epidemics and frequent outbreaks. Traditional vaccines struggle to offer comprehensive protection because of mismatches with circulating viral strains. The development of a broad-spectrum vaccine is therefore crucial. This paper explores the potential of mRNA vaccine technology to address these challenges by providing a swift, adaptable, and broad protective response against evolving influenza strains. We detail the mechanisms of antigenic variation in influenza viruses and discuss the rapid design and production, enhanced immunogenicity, encoding of multiple antigens, and safety and stability of mRNA vaccines compared to traditional methods. By leveraging these advantages, mRNA vaccines represent a revolutionary approach in influenza prevention, potentially offering broad-spectrum protection and significantly improving global influenza management and response strategies. |
| format | Article |
| id | doaj-art-067ae6e54a844e77997cae4c4d90bfad |
| institution | DOAJ |
| issn | 2076-393X |
| language | English |
| publishDate | 2024-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Vaccines |
| spelling | doaj-art-067ae6e54a844e77997cae4c4d90bfad2025-08-20T02:50:44ZengMDPI AGVaccines2076-393X2024-12-011212138210.3390/vaccines12121382Advantages of Broad-Spectrum Influenza mRNA Vaccines and Their Impact on Pulmonary InfluenzaZiqi Cheng0Junfeng Ma1Chenyan Zhao2National Engineering Laboratory for AIDS Vaccine, School of Life Sciences, Jilin University, Changchun 130012, ChinaNational Engineering Laboratory for AIDS Vaccine, School of Life Sciences, Jilin University, Changchun 130012, ChinaDivision of HIV/AIDS and Sex-Transmitted Virus Vaccines, National Institutes for Food and Drug Control (NIFDC), Beijing 102629, ChinaInfluenza poses a significant global health challenge due to its rapid mutation and antigenic variability, which often leads to seasonal epidemics and frequent outbreaks. Traditional vaccines struggle to offer comprehensive protection because of mismatches with circulating viral strains. The development of a broad-spectrum vaccine is therefore crucial. This paper explores the potential of mRNA vaccine technology to address these challenges by providing a swift, adaptable, and broad protective response against evolving influenza strains. We detail the mechanisms of antigenic variation in influenza viruses and discuss the rapid design and production, enhanced immunogenicity, encoding of multiple antigens, and safety and stability of mRNA vaccines compared to traditional methods. By leveraging these advantages, mRNA vaccines represent a revolutionary approach in influenza prevention, potentially offering broad-spectrum protection and significantly improving global influenza management and response strategies.https://www.mdpi.com/2076-393X/12/12/1382broad-spectrum influenza vaccinemRNA Vaccine mRNApulmonary influenza |
| spellingShingle | Ziqi Cheng Junfeng Ma Chenyan Zhao Advantages of Broad-Spectrum Influenza mRNA Vaccines and Their Impact on Pulmonary Influenza Vaccines broad-spectrum influenza vaccine mRNA Vaccine mRNA pulmonary influenza |
| title | Advantages of Broad-Spectrum Influenza mRNA Vaccines and Their Impact on Pulmonary Influenza |
| title_full | Advantages of Broad-Spectrum Influenza mRNA Vaccines and Their Impact on Pulmonary Influenza |
| title_fullStr | Advantages of Broad-Spectrum Influenza mRNA Vaccines and Their Impact on Pulmonary Influenza |
| title_full_unstemmed | Advantages of Broad-Spectrum Influenza mRNA Vaccines and Their Impact on Pulmonary Influenza |
| title_short | Advantages of Broad-Spectrum Influenza mRNA Vaccines and Their Impact on Pulmonary Influenza |
| title_sort | advantages of broad spectrum influenza mrna vaccines and their impact on pulmonary influenza |
| topic | broad-spectrum influenza vaccine mRNA Vaccine mRNA pulmonary influenza |
| url | https://www.mdpi.com/2076-393X/12/12/1382 |
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