Association between EASIX and acute kidney injury in critically ill cancer patients
Abstract Background To analyze the relationship between endothelial activation and stress index (EASIX) and the occurrence of acute kidney injury (AKI) in critically ill cancer patients. Methods Critically ill cancer patients were selected from the Medical Information Mart for Intensive Care IV (MIM...
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BMC
2024-12-01
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| Series: | BMC Nephrology |
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| Online Access: | https://doi.org/10.1186/s12882-024-03887-2 |
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| author | Feng Deng Jiandong Lin Hairong Lin |
| author_facet | Feng Deng Jiandong Lin Hairong Lin |
| author_sort | Feng Deng |
| collection | DOAJ |
| description | Abstract Background To analyze the relationship between endothelial activation and stress index (EASIX) and the occurrence of acute kidney injury (AKI) in critically ill cancer patients. Methods Critically ill cancer patients were selected from the Medical Information Mart for Intensive Care IV (MIMIC-IV). Multivariate logistic regression was used to analyze the association between EASIX and the occurrence of AKI in critically ill cancer patients. Results One thousand forty-one cancer patients were retrospectively included, including 607 men and 434 women with mean age of 64.86 ± 13.67 years. Univariate analysis showed that high EASIX levels were associated with an increased risk of AKI occurrence in intensive care unit (ICU) cancer patients (OR: 1.47,95% CI: 1.13–1.91, P < 0.05). After adjusting for other confounders, high EASIX levels remained an independent risk factor predicting the development of AKI (OR: 1.42,95% CI: 1.08–1.88, P < 0.05). Trends in effect sizes were generally consistent across all subgroups in the prespecified subgroup analyses. Conclusion EASIX is an independent risk factor for AKI in critically ill cancer patients. More prospective studies are needed to validate the effect of EASIX on the occurrence of AKI in critically ill cancer patients in the future. |
| format | Article |
| id | doaj-art-067989e7498f42918bd520a12e586a55 |
| institution | DOAJ |
| issn | 1471-2369 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Nephrology |
| spelling | doaj-art-067989e7498f42918bd520a12e586a552025-08-20T02:40:14ZengBMCBMC Nephrology1471-23692024-12-012511910.1186/s12882-024-03887-2Association between EASIX and acute kidney injury in critically ill cancer patientsFeng Deng0Jiandong Lin1Hairong Lin2Department of Intensive Care Unit, Clinical Oncology School of Fujian Medical University, Fujian Cancer HospitalDepartment of Intensive Care Unit, the First Affiliated Hospital of Fujian Medical UniversityDepartment of Intensive Care Unit, the First Affiliated Hospital of Fujian Medical UniversityAbstract Background To analyze the relationship between endothelial activation and stress index (EASIX) and the occurrence of acute kidney injury (AKI) in critically ill cancer patients. Methods Critically ill cancer patients were selected from the Medical Information Mart for Intensive Care IV (MIMIC-IV). Multivariate logistic regression was used to analyze the association between EASIX and the occurrence of AKI in critically ill cancer patients. Results One thousand forty-one cancer patients were retrospectively included, including 607 men and 434 women with mean age of 64.86 ± 13.67 years. Univariate analysis showed that high EASIX levels were associated with an increased risk of AKI occurrence in intensive care unit (ICU) cancer patients (OR: 1.47,95% CI: 1.13–1.91, P < 0.05). After adjusting for other confounders, high EASIX levels remained an independent risk factor predicting the development of AKI (OR: 1.42,95% CI: 1.08–1.88, P < 0.05). Trends in effect sizes were generally consistent across all subgroups in the prespecified subgroup analyses. Conclusion EASIX is an independent risk factor for AKI in critically ill cancer patients. More prospective studies are needed to validate the effect of EASIX on the occurrence of AKI in critically ill cancer patients in the future.https://doi.org/10.1186/s12882-024-03887-2Endothelial injuryMIMIC-IVEndothelial activation and stress indexCancerAKI |
| spellingShingle | Feng Deng Jiandong Lin Hairong Lin Association between EASIX and acute kidney injury in critically ill cancer patients BMC Nephrology Endothelial injury MIMIC-IV Endothelial activation and stress index Cancer AKI |
| title | Association between EASIX and acute kidney injury in critically ill cancer patients |
| title_full | Association between EASIX and acute kidney injury in critically ill cancer patients |
| title_fullStr | Association between EASIX and acute kidney injury in critically ill cancer patients |
| title_full_unstemmed | Association between EASIX and acute kidney injury in critically ill cancer patients |
| title_short | Association between EASIX and acute kidney injury in critically ill cancer patients |
| title_sort | association between easix and acute kidney injury in critically ill cancer patients |
| topic | Endothelial injury MIMIC-IV Endothelial activation and stress index Cancer AKI |
| url | https://doi.org/10.1186/s12882-024-03887-2 |
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