Role of Central Nervous System Circuits in Promotion of Breast Cancer Progression by Depression
With the development of neuroscience and oncology, the direct regulation effect of central nervous system circuits on tumors has been gradually revealed. Evidence indicates that the therapy targeting emotion-related encephalic regions may have great potential in blocking the promotion of breast canc...
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| Format: | Article |
| Language: | zho |
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Magazine House of Cancer Research on Prevention and Treatment
2025-01-01
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| Series: | Zhongliu Fangzhi Yanjiu |
| Subjects: | |
| Online Access: | http://www.zlfzyj.com/cn/article/doi/10.3971/j.issn.1000-8578.2025.24.0841 |
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| author | Yingchao WU Yuqi LIANG Qian ZUO Qianjun CHEN |
| author_facet | Yingchao WU Yuqi LIANG Qian ZUO Qianjun CHEN |
| author_sort | Yingchao WU |
| collection | DOAJ |
| description | With the development of neuroscience and oncology, the direct regulation effect of central nervous system circuits on tumors has been gradually revealed. Evidence indicates that the therapy targeting emotion-related encephalic regions may have great potential in blocking the promotion of breast cancer progression by depression. The underlying complex mechanisms involve the generation of depression and the regulation of tumors by central nervous system circuits. However, a systematic summary is lacking in this field. This article reviews the latest research progress of the central nervous system circuits and the generation of depression, the neural connection between the central nervous system and peripheral tumor, and the regulation of the tumor immune microenvironment by the sympathetic nervous system. It also systematically investigates the potential mechanism of the central nervous system circuit in the promotion of breast cancer progression by depression to establish new solutions for the comprehensive treatment of breast cancer. |
| format | Article |
| id | doaj-art-066a72e87d4b45e699e1222419b81414 |
| institution | Kabale University |
| issn | 1000-8578 |
| language | zho |
| publishDate | 2025-01-01 |
| publisher | Magazine House of Cancer Research on Prevention and Treatment |
| record_format | Article |
| series | Zhongliu Fangzhi Yanjiu |
| spelling | doaj-art-066a72e87d4b45e699e1222419b814142025-01-23T07:44:48ZzhoMagazine House of Cancer Research on Prevention and TreatmentZhongliu Fangzhi Yanjiu1000-85782025-01-01521253010.3971/j.issn.1000-8578.2025.24.084120240841Role of Central Nervous System Circuits in Promotion of Breast Cancer Progression by DepressionYingchao WU0Yuqi LIANG1Qian ZUO2Qianjun CHEN3The Second Clinical Medical College of Guangzhou University of Chinese Medicine, Guangzhou 510405, ChinaThe Second Clinical Medical College of Guangzhou University of Chinese Medicine, Guangzhou 510405, ChinaState Key Laboratory of Traditional Chinese Medicine Syndrome, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangdong 510120, ChinaState Key Laboratory of Traditional Chinese Medicine Syndrome, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangdong 510120, ChinaWith the development of neuroscience and oncology, the direct regulation effect of central nervous system circuits on tumors has been gradually revealed. Evidence indicates that the therapy targeting emotion-related encephalic regions may have great potential in blocking the promotion of breast cancer progression by depression. The underlying complex mechanisms involve the generation of depression and the regulation of tumors by central nervous system circuits. However, a systematic summary is lacking in this field. This article reviews the latest research progress of the central nervous system circuits and the generation of depression, the neural connection between the central nervous system and peripheral tumor, and the regulation of the tumor immune microenvironment by the sympathetic nervous system. It also systematically investigates the potential mechanism of the central nervous system circuit in the promotion of breast cancer progression by depression to establish new solutions for the comprehensive treatment of breast cancer.http://www.zlfzyj.com/cn/article/doi/10.3971/j.issn.1000-8578.2025.24.0841depressionbreast cancerneural circuitsympathetic nervetumor immune microenvironment |
| spellingShingle | Yingchao WU Yuqi LIANG Qian ZUO Qianjun CHEN Role of Central Nervous System Circuits in Promotion of Breast Cancer Progression by Depression Zhongliu Fangzhi Yanjiu depression breast cancer neural circuit sympathetic nerve tumor immune microenvironment |
| title | Role of Central Nervous System Circuits in Promotion of Breast Cancer Progression by Depression |
| title_full | Role of Central Nervous System Circuits in Promotion of Breast Cancer Progression by Depression |
| title_fullStr | Role of Central Nervous System Circuits in Promotion of Breast Cancer Progression by Depression |
| title_full_unstemmed | Role of Central Nervous System Circuits in Promotion of Breast Cancer Progression by Depression |
| title_short | Role of Central Nervous System Circuits in Promotion of Breast Cancer Progression by Depression |
| title_sort | role of central nervous system circuits in promotion of breast cancer progression by depression |
| topic | depression breast cancer neural circuit sympathetic nerve tumor immune microenvironment |
| url | http://www.zlfzyj.com/cn/article/doi/10.3971/j.issn.1000-8578.2025.24.0841 |
| work_keys_str_mv | AT yingchaowu roleofcentralnervoussystemcircuitsinpromotionofbreastcancerprogressionbydepression AT yuqiliang roleofcentralnervoussystemcircuitsinpromotionofbreastcancerprogressionbydepression AT qianzuo roleofcentralnervoussystemcircuitsinpromotionofbreastcancerprogressionbydepression AT qianjunchen roleofcentralnervoussystemcircuitsinpromotionofbreastcancerprogressionbydepression |