Dynamic cerebral autoregulation during and 3 months after endovascular treatment in large vessel occlusion stroke

Dynamic cerebral autoregulation during and 3 months after endovascular treatment in large vessel occlusion stroke

Abstract Acute ischemic stroke caused by large vessel occlusion is effectively treated by endovascular treatment (EVT). However, treatment could be further refined by improved understanding of the pathophysiology, including dynamic cerebral autoregulation (dCA). Near-infrared spectroscopy (NIRS) req...

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Main Authors: Adam Vittrup Heiberg, Troels Gil Lukassen, Thomas Clement Truelsen, Henrik Gutte Borgwardt, Goetz Benndorf, Christine Sølling, Henrik Winther Schytz, Kirsten Møller, Klaus Hansen, Helle Klingenberg Iversen
Format: Article
Language:English
Published: Nature Portfolio 2025-08-01
Series:Scientific Reports
Subjects:
Acute ischemic stroke
Endovascular treatment
Dynamic cerebral autoregulation
Near-infrared spectroscopy
Transfer function analysis
Online Access:https://doi.org/10.1038/s41598-025-14672-y
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Summary:Abstract Acute ischemic stroke caused by large vessel occlusion is effectively treated by endovascular treatment (EVT). However, treatment could be further refined by improved understanding of the pathophysiology, including dynamic cerebral autoregulation (dCA). Near-infrared spectroscopy (NIRS) requires virtually no setup time and enables dCA investigation during EVT by measuring dynamic concentration in cortical oxygenated hemoglobin (OxyHb). We aimed to investigate dCA during EVT, before and after recanalization, and at follow-up (FU) after 24 h and 90 days. We applied interhemispheric transfer function analysis (TFA) of low-frequency (LF) oscillations (0.07–0.2 Hz) in OxyHb that yields the dCA measures, gain and phase shift. LF phase shift increased immediately after recanalization for patients with milder symptom severity and at 24-h FU for patients with more severe symptoms, but contralateral phase shift needs further investigation. We found higher LF gain in patients with favorable outcome and in patients starting intravenous thrombolysis before EVT. Adjusted for age, infarct size before EVT, and recanalization success, average LF gain predicted independent functional outcome, symptom severity and mortality at 90-day FU. In conclusion, interhemispheric TFA based on NIRS was feasible to assess dCA during EVT and provided insights that could potentially be applied in the development of individualized treatment. Clinical Trial Registration ClinicalTrial.gov: NCT03738644. https://clinicaltrials.gov/study/NCT03738644 .
ISSN:2045-2322

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