Frontoparietal and temporal brain alterations post-cardiopulmonary bypass
Summary: Patients undergoing cardiopulmonary bypass (CPB) often experience neurological complications, but the neurobiological mechanisms remain unclear. This study combined resting-state fMRI, structural MRI, and cognitive testing to examine brain changes in 124 CPB patients and matched controls. R...
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| Language: | English |
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Elsevier
2025-04-01
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| Series: | iScience |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2589004225004481 |
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| author | Si Zhang Tianbo Li Zhifeng Wu Weijie Fan Wei Li Haiyu Zhang Li Wen Yong Wang Dong Zhang |
| author_facet | Si Zhang Tianbo Li Zhifeng Wu Weijie Fan Wei Li Haiyu Zhang Li Wen Yong Wang Dong Zhang |
| author_sort | Si Zhang |
| collection | DOAJ |
| description | Summary: Patients undergoing cardiopulmonary bypass (CPB) often experience neurological complications, but the neurobiological mechanisms remain unclear. This study combined resting-state fMRI, structural MRI, and cognitive testing to examine brain changes in 124 CPB patients and matched controls. Reduced amplitude of low-frequency fluctuation (ALFF) in the bilateral frontoparietal lobes indicated diminished neural activity among patients, and these ALFF values were positively correlated with the degree of executive dysfunction measured by the attention network test. Functional connectivity within the frontoparietal executive control network was weakened. Brain structural analysis revealed cortical thinning in frontoparietal and temporal regions, increased sulcal depth in medial orbitofrontal areas, and reduced gyrification in the insula suggesting long-term morphological impacts. These findings demonstrate CPB-associated functional and structural alterations in brain regions critical for cognition, providing neuroimaging evidence for postoperative dysfunction and potential neuroprotective strategies. |
| format | Article |
| id | doaj-art-066411ecce9a4f91979b9b3ee487e93b |
| institution | DOAJ |
| issn | 2589-0042 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Elsevier |
| record_format | Article |
| series | iScience |
| spelling | doaj-art-066411ecce9a4f91979b9b3ee487e93b2025-08-20T02:50:56ZengElsevieriScience2589-00422025-04-0128411218710.1016/j.isci.2025.112187Frontoparietal and temporal brain alterations post-cardiopulmonary bypassSi Zhang0Tianbo Li1Zhifeng Wu2Weijie Fan3Wei Li4Haiyu Zhang5Li Wen6Yong Wang7Dong Zhang8Department of Radiology, Xinqiao Hospital, Army Medical University, Chongqing 400037, P.R. ChinaDepartment of Cardiovascular Surgery, Xinqiao Hospital, Army Medical University, Chongqing 400037, P.R. ChinaDepartment of Pediatrics, Xinqiao Hospital, Army Medical University, Chongqing 400037, P.R. ChinaDepartment of Radiology, Xinqiao Hospital, Army Medical University, Chongqing 400037, P.R. ChinaDepartment of Radiology, 987th Hospital of Joint Logistics Support Force of Chinese People’s Liberation Army, Baoji, Shanxi Province 721015, P.R. ChinaDepartment of Radiology, Xinqiao Hospital, Army Medical University, Chongqing 400037, P.R. ChinaDepartment of Radiology, Xinqiao Hospital, Army Medical University, Chongqing 400037, P.R. ChinaDepartment of Cardiovascular Surgery, Xinqiao Hospital, Army Medical University, Chongqing 400037, P.R. China; Corresponding authorDepartment of Radiology, Xinqiao Hospital, Army Medical University, Chongqing 400037, P.R. China; Corresponding authorSummary: Patients undergoing cardiopulmonary bypass (CPB) often experience neurological complications, but the neurobiological mechanisms remain unclear. This study combined resting-state fMRI, structural MRI, and cognitive testing to examine brain changes in 124 CPB patients and matched controls. Reduced amplitude of low-frequency fluctuation (ALFF) in the bilateral frontoparietal lobes indicated diminished neural activity among patients, and these ALFF values were positively correlated with the degree of executive dysfunction measured by the attention network test. Functional connectivity within the frontoparietal executive control network was weakened. Brain structural analysis revealed cortical thinning in frontoparietal and temporal regions, increased sulcal depth in medial orbitofrontal areas, and reduced gyrification in the insula suggesting long-term morphological impacts. These findings demonstrate CPB-associated functional and structural alterations in brain regions critical for cognition, providing neuroimaging evidence for postoperative dysfunction and potential neuroprotective strategies.http://www.sciencedirect.com/science/article/pii/S2589004225004481cardiovascular medicinemedical imaging |
| spellingShingle | Si Zhang Tianbo Li Zhifeng Wu Weijie Fan Wei Li Haiyu Zhang Li Wen Yong Wang Dong Zhang Frontoparietal and temporal brain alterations post-cardiopulmonary bypass iScience cardiovascular medicine medical imaging |
| title | Frontoparietal and temporal brain alterations post-cardiopulmonary bypass |
| title_full | Frontoparietal and temporal brain alterations post-cardiopulmonary bypass |
| title_fullStr | Frontoparietal and temporal brain alterations post-cardiopulmonary bypass |
| title_full_unstemmed | Frontoparietal and temporal brain alterations post-cardiopulmonary bypass |
| title_short | Frontoparietal and temporal brain alterations post-cardiopulmonary bypass |
| title_sort | frontoparietal and temporal brain alterations post cardiopulmonary bypass |
| topic | cardiovascular medicine medical imaging |
| url | http://www.sciencedirect.com/science/article/pii/S2589004225004481 |
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