Quantifying task-locked information transmission between cortical areas with TMS-EEG
Objective: This study aims to develop TMS-EEG (Transcranial magnetic stimulation combined with EEG) technology to detect task-locked neural network activation and dynamically quantify information transmission. Approach: 30 participants performed visually guided gap saccade tasks while TMS-EEG data w...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-08-01
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| Series: | NeuroImage |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S105381192500326X |
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| author | Zhaohuan Ding Wenbo Ma Leixiao Feng Mingsha Zhang Xiaoli Li |
| author_facet | Zhaohuan Ding Wenbo Ma Leixiao Feng Mingsha Zhang Xiaoli Li |
| author_sort | Zhaohuan Ding |
| collection | DOAJ |
| description | Objective: This study aims to develop TMS-EEG (Transcranial magnetic stimulation combined with EEG) technology to detect task-locked neural network activation and dynamically quantify information transmission. Approach: 30 participants performed visually guided gap saccade tasks while TMS-EEG data were recorded, with the TMS pulses delivered to prefrontal cortex (PFC) and posterior parietal cortex (PPC) at different task stages. The directed transfer function (DTF) method was applied to TMS-EEG data to indicate the information flow. By analyzing the channel combinations associated with the PFC and PPC, we calculated differences in information flow within the alpha, beta, and gamma frequency bands to determine whether TMS-EEG could quantitatively characterize the direction of information flow between cortical areas. Main results: Analysis of eye tracker data revealed that all participants successfully performed the saccade task, with a correct rate exceeding 90 %. The mean saccade latency was 132.25 ± 22.59 ms after target appearance. Stimulation of the PFC and PPC revealed significant differences in information flow in the gamma bands at different time points. Specifically, during the preparatory period, the C3 electrode acts as a hub for incoming information from O1, later transitioning to send information towards F4 and O1 post-target. Then, P3 emerges as a hub, sending data towards P4, with connectivity between them intensifying post 100 ms from the target's appearance. Significance: This study utilized DTF values derived from TMS-EEG to characterize information flow between cortical areas during the gap saccade task. This approach provides a novel method for quantifying dynamic changes in connectivity and causality between cortical areas during task processing. |
| format | Article |
| id | doaj-art-065dacc9525d4c4a9cd48c19f03dc875 |
| institution | DOAJ |
| issn | 1095-9572 |
| language | English |
| publishDate | 2025-08-01 |
| publisher | Elsevier |
| record_format | Article |
| series | NeuroImage |
| spelling | doaj-art-065dacc9525d4c4a9cd48c19f03dc8752025-08-20T03:21:38ZengElsevierNeuroImage1095-95722025-08-0131712132310.1016/j.neuroimage.2025.121323Quantifying task-locked information transmission between cortical areas with TMS-EEGZhaohuan Ding0Wenbo Ma1Leixiao Feng2Mingsha Zhang3Xiaoli Li4Shien-Ming Wu School of Intelligent Engineering, South China University of Technology, Guangzhou 510640, ChinaSchool of psychiatry, North Sichuan Medical College, Nanchong, Sichuan 637000, ChinaState Key Laboratory of Cognitive Neuroscience and Learning & IDG/McGovern Institute for Brain Research, Beijing Normal University, Beijing 100875, ChinaState Key Laboratory of Cognitive Neuroscience and Learning & IDG/McGovern Institute for Brain Research, Beijing Normal University, Beijing 100875, ChinaState Key Laboratory of Cognitive Neuroscience and Learning & IDG/McGovern Institute for Brain Research, Beijing Normal University, Beijing 100875, China; Guangdong Artificial Intelligence and Digital Economy Laboratory (Guangzhou), Guangzhou 510335, China; School of Automation Science and Engineering, South China University of Technology, Guangzhou 510641, China; Corresponding author.Objective: This study aims to develop TMS-EEG (Transcranial magnetic stimulation combined with EEG) technology to detect task-locked neural network activation and dynamically quantify information transmission. Approach: 30 participants performed visually guided gap saccade tasks while TMS-EEG data were recorded, with the TMS pulses delivered to prefrontal cortex (PFC) and posterior parietal cortex (PPC) at different task stages. The directed transfer function (DTF) method was applied to TMS-EEG data to indicate the information flow. By analyzing the channel combinations associated with the PFC and PPC, we calculated differences in information flow within the alpha, beta, and gamma frequency bands to determine whether TMS-EEG could quantitatively characterize the direction of information flow between cortical areas. Main results: Analysis of eye tracker data revealed that all participants successfully performed the saccade task, with a correct rate exceeding 90 %. The mean saccade latency was 132.25 ± 22.59 ms after target appearance. Stimulation of the PFC and PPC revealed significant differences in information flow in the gamma bands at different time points. Specifically, during the preparatory period, the C3 electrode acts as a hub for incoming information from O1, later transitioning to send information towards F4 and O1 post-target. Then, P3 emerges as a hub, sending data towards P4, with connectivity between them intensifying post 100 ms from the target's appearance. Significance: This study utilized DTF values derived from TMS-EEG to characterize information flow between cortical areas during the gap saccade task. This approach provides a novel method for quantifying dynamic changes in connectivity and causality between cortical areas during task processing.http://www.sciencedirect.com/science/article/pii/S105381192500326XTMS-EEGSaccade taskDirected transfer function (DTF)Information transmission connectome |
| spellingShingle | Zhaohuan Ding Wenbo Ma Leixiao Feng Mingsha Zhang Xiaoli Li Quantifying task-locked information transmission between cortical areas with TMS-EEG NeuroImage TMS-EEG Saccade task Directed transfer function (DTF) Information transmission connectome |
| title | Quantifying task-locked information transmission between cortical areas with TMS-EEG |
| title_full | Quantifying task-locked information transmission between cortical areas with TMS-EEG |
| title_fullStr | Quantifying task-locked information transmission between cortical areas with TMS-EEG |
| title_full_unstemmed | Quantifying task-locked information transmission between cortical areas with TMS-EEG |
| title_short | Quantifying task-locked information transmission between cortical areas with TMS-EEG |
| title_sort | quantifying task locked information transmission between cortical areas with tms eeg |
| topic | TMS-EEG Saccade task Directed transfer function (DTF) Information transmission connectome |
| url | http://www.sciencedirect.com/science/article/pii/S105381192500326X |
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