Neuromyelitis optica spectrum disorder in patient with systemic lupus erythematosus - our experience
Introduction. Neuromyelitis optica spectrum disorder (NMOSD) is a rare demyelinating immune-mediated central nervous system disease. It is extremely rare to occur in patients with systemic lupus erythematosus (SLE), and it represents a diagnostic and therapeutic challenge. Case report. A 38-year-old...
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| Format: | Article |
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Ministry of Defence of the Republic of Serbia, University of Defence, Belgrade
2018-01-01
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| Series: | Vojnosanitetski Pregled |
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| Online Access: | http://www.doiserbia.nb.rs/img/doi/0042-8450/2018/0042-84501600322B.pdf |
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| author | Božić Ksenija Komatina Nenad Petronijević Milan Knežević Bojana Kostić Dejan Stefanović Dušan |
| author_facet | Božić Ksenija Komatina Nenad Petronijević Milan Knežević Bojana Kostić Dejan Stefanović Dušan |
| author_sort | Božić Ksenija |
| collection | DOAJ |
| description | Introduction. Neuromyelitis optica spectrum disorder (NMOSD) is a rare demyelinating immune-mediated central nervous system disease. It is extremely rare to occur in patients with systemic lupus erythematosus (SLE), and it represents a diagnostic and therapeutic challenge. Case report. A 38-year-old Caucasian woman with medical history of SLE and new onset of flaccid paraparesis, fecal and urinary incontinence, persistent nausea and vomiting was admitted to our hospital. Based on the clinical presentation, magnetic resonance imaging findings and positive aquaporin 4 (AQP4) antibodies, a NMOSD with coexisting SLE were diagnosed. Pulse-doses of cyclophosphamide and glucocorticoids were efficient in patient treatment. Conclusion. In a patient with SLE and symptoms of longitudinal extensive transverse myelitis and/or optic neuritis and area postrema syndrome, assessment of AQP4 antibodies is neccessary for diagnosing NMOSD. Accurate diagnosis, and timely and long-term administration of immunosuppressive therapy are crucial for favorable outcome of these two coexisting diseases. |
| format | Article |
| id | doaj-art-065a458feba34027ae277c3d51426b34 |
| institution | Kabale University |
| issn | 0042-8450 2406-0720 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Ministry of Defence of the Republic of Serbia, University of Defence, Belgrade |
| record_format | Article |
| series | Vojnosanitetski Pregled |
| spelling | doaj-art-065a458feba34027ae277c3d51426b342025-08-20T03:54:16ZengMinistry of Defence of the Republic of Serbia, University of Defence, BelgradeVojnosanitetski Pregled0042-84502406-07202018-01-0175110410710.2298/VSP160331322B0042-84501600322BNeuromyelitis optica spectrum disorder in patient with systemic lupus erythematosus - our experienceBožić Ksenija0Komatina Nenad1Petronijević Milan2Knežević Bojana3Kostić Dejan4Stefanović Dušan5Military Medical Academy, Clinic of Rheumatology, BelgradeMilitary Medical Academy, Clinic of Neurology, BelgradeMilitary Medical Academy, Clinic of Rheumatology, Belgrade + University of Defense, Faculty of Medicine of the Military Medical Academy, BelgradeMilitary Medical Academy, Clinic of Rheumatology, BelgradeUniversity of Defense, Faculty of Medicine of the Military Medical Academy, Belgrade + Military Medical Academy, Institute of Radiology, BelgradeMilitary Medical Academy, Clinic of Rheumatology, Belgrade + University of Defense, Faculty of Medicine of the Military Medical Academy, BelgradeIntroduction. Neuromyelitis optica spectrum disorder (NMOSD) is a rare demyelinating immune-mediated central nervous system disease. It is extremely rare to occur in patients with systemic lupus erythematosus (SLE), and it represents a diagnostic and therapeutic challenge. Case report. A 38-year-old Caucasian woman with medical history of SLE and new onset of flaccid paraparesis, fecal and urinary incontinence, persistent nausea and vomiting was admitted to our hospital. Based on the clinical presentation, magnetic resonance imaging findings and positive aquaporin 4 (AQP4) antibodies, a NMOSD with coexisting SLE were diagnosed. Pulse-doses of cyclophosphamide and glucocorticoids were efficient in patient treatment. Conclusion. In a patient with SLE and symptoms of longitudinal extensive transverse myelitis and/or optic neuritis and area postrema syndrome, assessment of AQP4 antibodies is neccessary for diagnosing NMOSD. Accurate diagnosis, and timely and long-term administration of immunosuppressive therapy are crucial for favorable outcome of these two coexisting diseases.http://www.doiserbia.nb.rs/img/doi/0042-8450/2018/0042-84501600322B.pdflupus erithematosus, systemicneuromyelitis opticadiagnosisaquaporin-4antibodiesdrug therapytreatment outcome |
| spellingShingle | Božić Ksenija Komatina Nenad Petronijević Milan Knežević Bojana Kostić Dejan Stefanović Dušan Neuromyelitis optica spectrum disorder in patient with systemic lupus erythematosus - our experience Vojnosanitetski Pregled lupus erithematosus, systemic neuromyelitis optica diagnosis aquaporin-4 antibodies drug therapy treatment outcome |
| title | Neuromyelitis optica spectrum disorder in patient with systemic lupus erythematosus - our experience |
| title_full | Neuromyelitis optica spectrum disorder in patient with systemic lupus erythematosus - our experience |
| title_fullStr | Neuromyelitis optica spectrum disorder in patient with systemic lupus erythematosus - our experience |
| title_full_unstemmed | Neuromyelitis optica spectrum disorder in patient with systemic lupus erythematosus - our experience |
| title_short | Neuromyelitis optica spectrum disorder in patient with systemic lupus erythematosus - our experience |
| title_sort | neuromyelitis optica spectrum disorder in patient with systemic lupus erythematosus our experience |
| topic | lupus erithematosus, systemic neuromyelitis optica diagnosis aquaporin-4 antibodies drug therapy treatment outcome |
| url | http://www.doiserbia.nb.rs/img/doi/0042-8450/2018/0042-84501600322B.pdf |
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