tRNA-derived small RNAs (tsRNAs): establishing their dominance in the regulation of human cancer
The main function of transfer RNAs (tRNAs) is to carry amino acids into the ribosome and synthesize proteins under the guidance of messenger RNAs (mRNAs). In addition to this, it has been observed that tRNAs undergo precise cleavage at specific loci, giving rise to an extensive array of distinct sma...
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Frontiers Media S.A.
2024-11-01
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| Series: | Frontiers in Genetics |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fgene.2024.1466213/full |
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| author | Li Gong Yajie Hu Ling Pan Ling Pan Yufeng Cheng Yufeng Cheng |
| author_facet | Li Gong Yajie Hu Ling Pan Ling Pan Yufeng Cheng Yufeng Cheng |
| author_sort | Li Gong |
| collection | DOAJ |
| description | The main function of transfer RNAs (tRNAs) is to carry amino acids into the ribosome and synthesize proteins under the guidance of messenger RNAs (mRNAs). In addition to this, it has been observed that tRNAs undergo precise cleavage at specific loci, giving rise to an extensive array of distinct small RNAs, termed tRNA-derived small RNAs (tsRNAs). Existing studies have shown that tsRNAs are widely present across various organisms and comprehensively regulate gene expression, aberrant expression of tsRNAs is inextricably linked to tumorigenesis and development, thus, a systematic understanding of tsRNAs is necessary. This review aims to comprehensively delineate the genesis and expression patterns of tsRNAs, elucidate their diverse functions and emphasize their prospective clinical application as biomarkers and targets for therapy. It is noteworthy that we innovatively address the roles played by tsRNAs in human cancers at the level of the hallmarks of tumorigenesis proposed by Hanahan in anticipation of a broad understanding of tsRNAs and to guide the treatment of tumors. |
| format | Article |
| id | doaj-art-065621d423cb407198c059c058946b4e |
| institution | OA Journals |
| issn | 1664-8021 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Genetics |
| spelling | doaj-art-065621d423cb407198c059c058946b4e2025-08-20T02:23:09ZengFrontiers Media S.A.Frontiers in Genetics1664-80212024-11-011510.3389/fgene.2024.14662131466213tRNA-derived small RNAs (tsRNAs): establishing their dominance in the regulation of human cancerLi Gong0Yajie Hu1Ling Pan2Ling Pan3Yufeng Cheng4Yufeng Cheng5Department of Radiation Oncology, Cheeloo College of Medicine, Qilu Hospital of Shandong University, Shandong University, Jinan, Shandong, ChinaDepartment of Radiation Oncology, Cheeloo College of Medicine, Qilu Hospital of Shandong University, Shandong University, Jinan, Shandong, ChinaDepartment of Radiation Oncology, Cheeloo College of Medicine, Qilu Hospital of Shandong University, Shandong University, Jinan, Shandong, ChinaResearch Center for Basic Medical Sciences, Qilu Hospital of Shandong University, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, ChinaDepartment of Radiation Oncology, Cheeloo College of Medicine, Qilu Hospital of Shandong University, Shandong University, Jinan, Shandong, ChinaResearch Center for Basic Medical Sciences, Qilu Hospital of Shandong University, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, ChinaThe main function of transfer RNAs (tRNAs) is to carry amino acids into the ribosome and synthesize proteins under the guidance of messenger RNAs (mRNAs). In addition to this, it has been observed that tRNAs undergo precise cleavage at specific loci, giving rise to an extensive array of distinct small RNAs, termed tRNA-derived small RNAs (tsRNAs). Existing studies have shown that tsRNAs are widely present across various organisms and comprehensively regulate gene expression, aberrant expression of tsRNAs is inextricably linked to tumorigenesis and development, thus, a systematic understanding of tsRNAs is necessary. This review aims to comprehensively delineate the genesis and expression patterns of tsRNAs, elucidate their diverse functions and emphasize their prospective clinical application as biomarkers and targets for therapy. It is noteworthy that we innovatively address the roles played by tsRNAs in human cancers at the level of the hallmarks of tumorigenesis proposed by Hanahan in anticipation of a broad understanding of tsRNAs and to guide the treatment of tumors.https://www.frontiersin.org/articles/10.3389/fgene.2024.1466213/fulltRNA-derived small RNAstRNA-derived fragmentstRNA halveshallmarksbiomarkerstherapeutic targets |
| spellingShingle | Li Gong Yajie Hu Ling Pan Ling Pan Yufeng Cheng Yufeng Cheng tRNA-derived small RNAs (tsRNAs): establishing their dominance in the regulation of human cancer Frontiers in Genetics tRNA-derived small RNAs tRNA-derived fragments tRNA halves hallmarks biomarkers therapeutic targets |
| title | tRNA-derived small RNAs (tsRNAs): establishing their dominance in the regulation of human cancer |
| title_full | tRNA-derived small RNAs (tsRNAs): establishing their dominance in the regulation of human cancer |
| title_fullStr | tRNA-derived small RNAs (tsRNAs): establishing their dominance in the regulation of human cancer |
| title_full_unstemmed | tRNA-derived small RNAs (tsRNAs): establishing their dominance in the regulation of human cancer |
| title_short | tRNA-derived small RNAs (tsRNAs): establishing their dominance in the regulation of human cancer |
| title_sort | trna derived small rnas tsrnas establishing their dominance in the regulation of human cancer |
| topic | tRNA-derived small RNAs tRNA-derived fragments tRNA halves hallmarks biomarkers therapeutic targets |
| url | https://www.frontiersin.org/articles/10.3389/fgene.2024.1466213/full |
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