Large Cell Neuroendocrine Carcinoma of the Rectum Presenting with Extensive Metastatic Disease
Introduction. Rectal large cell neuroendocrine carcinoma (LCNEC) is a poorly differentiated neoplasm that is very rare and belongs within the poorest prognostic subgroup among primary colorectal neoplasms. Here, we describe a case of LCNEC of the rectum, which highlights the aggressive clinical cour...
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | Case Reports in Oncological Medicine |
| Online Access: | http://dx.doi.org/10.1155/2014/386379 |
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| author | Vinay Minocha Sania Shuja Robert Ali Emely Eid |
| author_facet | Vinay Minocha Sania Shuja Robert Ali Emely Eid |
| author_sort | Vinay Minocha |
| collection | DOAJ |
| description | Introduction. Rectal large cell neuroendocrine carcinoma (LCNEC) is a poorly differentiated neoplasm that is very rare and belongs within the poorest prognostic subgroup among primary colorectal neoplasms. Here, we describe a case of LCNEC of the rectum, which highlights the aggressive clinical course and poor prognosis associated with this disease. Case Presentation. We report a case of a 63-year-old male who presented to our hospital with a one-month history of lower abdominal pain, constipation, and weight loss. A computed tomography (CT) scan of the chest, abdomen, and pelvis revealed a rectal mass as well as metastatic disease of the liver and lung. Flexible sigmoidoscopy revealed a fungating, ulcerated and partially obstructing rectal mass located 6 cm from the anal verge. This mass was biopsied and pathological examination of the resected specimen revealed features consistent with a large cell neuroendocrine carcinoma. Conclusion. Rectal large cell neuroendocrine carcinomas are rare and have a significantly worse prognosis than adenocarcinomas. At diagnosis, a higher stage and metastatic disease are likely to be found. It is important to differentiate large cell, poorly differentiated neuroendocrine carcinomas from adenocarcinomas of the colon and rectum pathologically because patients may benefit from alternative cytotoxic chemotherapeutic regimens. |
| format | Article |
| id | doaj-art-0643dfc326ea445c8ad5cc53270a5e43 |
| institution | OA Journals |
| issn | 2090-6706 2090-6714 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Oncological Medicine |
| spelling | doaj-art-0643dfc326ea445c8ad5cc53270a5e432025-08-20T02:03:42ZengWileyCase Reports in Oncological Medicine2090-67062090-67142014-01-01201410.1155/2014/386379386379Large Cell Neuroendocrine Carcinoma of the Rectum Presenting with Extensive Metastatic DiseaseVinay Minocha0Sania Shuja1Robert Ali2Emely Eid3Division of Gastroenterology, Department of Internal Medicine, University of Florida, Jacksonville, FL, USADepartment of Pathology, University of Florida, Jacksonville, FL, USADivision of Gastroenterology, Department of Internal Medicine, University of Florida, Jacksonville, FL, USADivision of Gastroenterology, Department of Internal Medicine, University of Florida, Jacksonville, FL, USAIntroduction. Rectal large cell neuroendocrine carcinoma (LCNEC) is a poorly differentiated neoplasm that is very rare and belongs within the poorest prognostic subgroup among primary colorectal neoplasms. Here, we describe a case of LCNEC of the rectum, which highlights the aggressive clinical course and poor prognosis associated with this disease. Case Presentation. We report a case of a 63-year-old male who presented to our hospital with a one-month history of lower abdominal pain, constipation, and weight loss. A computed tomography (CT) scan of the chest, abdomen, and pelvis revealed a rectal mass as well as metastatic disease of the liver and lung. Flexible sigmoidoscopy revealed a fungating, ulcerated and partially obstructing rectal mass located 6 cm from the anal verge. This mass was biopsied and pathological examination of the resected specimen revealed features consistent with a large cell neuroendocrine carcinoma. Conclusion. Rectal large cell neuroendocrine carcinomas are rare and have a significantly worse prognosis than adenocarcinomas. At diagnosis, a higher stage and metastatic disease are likely to be found. It is important to differentiate large cell, poorly differentiated neuroendocrine carcinomas from adenocarcinomas of the colon and rectum pathologically because patients may benefit from alternative cytotoxic chemotherapeutic regimens.http://dx.doi.org/10.1155/2014/386379 |
| spellingShingle | Vinay Minocha Sania Shuja Robert Ali Emely Eid Large Cell Neuroendocrine Carcinoma of the Rectum Presenting with Extensive Metastatic Disease Case Reports in Oncological Medicine |
| title | Large Cell Neuroendocrine Carcinoma of the Rectum Presenting with Extensive Metastatic Disease |
| title_full | Large Cell Neuroendocrine Carcinoma of the Rectum Presenting with Extensive Metastatic Disease |
| title_fullStr | Large Cell Neuroendocrine Carcinoma of the Rectum Presenting with Extensive Metastatic Disease |
| title_full_unstemmed | Large Cell Neuroendocrine Carcinoma of the Rectum Presenting with Extensive Metastatic Disease |
| title_short | Large Cell Neuroendocrine Carcinoma of the Rectum Presenting with Extensive Metastatic Disease |
| title_sort | large cell neuroendocrine carcinoma of the rectum presenting with extensive metastatic disease |
| url | http://dx.doi.org/10.1155/2014/386379 |
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