P120 catenin expression and its correlation with E-cadherin in salivary gland neoplasms
Objectives: Altered P120 catenin expression has been associated with E-cadherin loss and poor prognosis in several cancers. The objectives of this study were to examine the P120 catenin expression in salivary gland neoplasms in correlation with E-cadherin and assess the relationships between their e...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2019-01-01
|
| Series: | Journal of Oral Biology and Craniofacial Research |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S221242681830126X |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850060797485514752 |
|---|---|
| author | Ekarat Phattarataratip Nicha Kositkittiwanit Pruch Kajornkiatkul Pataraporn Yeunyong Ratanatip Ratanapitak |
| author_facet | Ekarat Phattarataratip Nicha Kositkittiwanit Pruch Kajornkiatkul Pataraporn Yeunyong Ratanatip Ratanapitak |
| author_sort | Ekarat Phattarataratip |
| collection | DOAJ |
| description | Objectives: Altered P120 catenin expression has been associated with E-cadherin loss and poor prognosis in several cancers. The objectives of this study were to examine the P120 catenin expression in salivary gland neoplasms in correlation with E-cadherin and assess the relationships between their expression levels and pathologic characteristics. Methods: Fifty-two cases of salivary gland neoplasms, i.e. 25 mucoepidermoid carcinomas (MEC), 13 adenoid cystic carcinomas (ACC), 12 pleomorphic adenomas (PA) and 2 polymorphous adenocarcinomas (PAC) were included. The expression of P120 catenin and E-cadherin was investigated immunohistochemically. Results: Both P120 catenin and E-cadherin were overexpressed in salivary gland neoplasms, compared to normal tissue. P120 catenin was primarily detected on the membrane of neoplastic cells in most cases. A significant correlation between levels of expression of both proteins was noted in MECs. In ACCs and PA, ductal cells showed positive immunoreactivity, whereas myoepithelial cells variably expressed both proteins. Increased P120 catenin expression was significantly associated with the solid subtype of ACCs. Conclusions: The cadherin-catenin complex is preserved in the heterogenous tumor cell population in salivary gland neoplasms. Overexpression of P120 catenin may be involved in the progression to solid ACCs. |
| format | Article |
| id | doaj-art-063ffc1b796c4c42ab23f2eb41a60c2d |
| institution | DOAJ |
| issn | 2212-4268 |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Oral Biology and Craniofacial Research |
| spelling | doaj-art-063ffc1b796c4c42ab23f2eb41a60c2d2025-08-20T02:50:27ZengElsevierJournal of Oral Biology and Craniofacial Research2212-42682019-01-0191576210.1016/j.jobcr.2018.09.005P120 catenin expression and its correlation with E-cadherin in salivary gland neoplasmsEkarat Phattarataratip0Nicha Kositkittiwanit1Pruch Kajornkiatkul2Pataraporn Yeunyong3Ratanatip Ratanapitak4Department of Oral Pathology, Faculty of Dentistry, Chulalongkorn University, Henri-Dunant Road, Pathumwan, Bangkok, 10330, Thailand; Corresponding author.Faculty of Dentistry, Chulalongkorn University, Henri-Dunant Road, Pathumwan, Bangkok, 10330, ThailandFaculty of Dentistry, Chulalongkorn University, Henri-Dunant Road, Pathumwan, Bangkok, 10330, ThailandFaculty of Dentistry, Chulalongkorn University, Henri-Dunant Road, Pathumwan, Bangkok, 10330, ThailandFaculty of Dentistry, Chulalongkorn University, Henri-Dunant Road, Pathumwan, Bangkok, 10330, ThailandObjectives: Altered P120 catenin expression has been associated with E-cadherin loss and poor prognosis in several cancers. The objectives of this study were to examine the P120 catenin expression in salivary gland neoplasms in correlation with E-cadherin and assess the relationships between their expression levels and pathologic characteristics. Methods: Fifty-two cases of salivary gland neoplasms, i.e. 25 mucoepidermoid carcinomas (MEC), 13 adenoid cystic carcinomas (ACC), 12 pleomorphic adenomas (PA) and 2 polymorphous adenocarcinomas (PAC) were included. The expression of P120 catenin and E-cadherin was investigated immunohistochemically. Results: Both P120 catenin and E-cadherin were overexpressed in salivary gland neoplasms, compared to normal tissue. P120 catenin was primarily detected on the membrane of neoplastic cells in most cases. A significant correlation between levels of expression of both proteins was noted in MECs. In ACCs and PA, ductal cells showed positive immunoreactivity, whereas myoepithelial cells variably expressed both proteins. Increased P120 catenin expression was significantly associated with the solid subtype of ACCs. Conclusions: The cadherin-catenin complex is preserved in the heterogenous tumor cell population in salivary gland neoplasms. Overexpression of P120 catenin may be involved in the progression to solid ACCs.http://www.sciencedirect.com/science/article/pii/S221242681830126XP120 cateninE-cadherinMucoepidermoid carcinomaAdenoid cystic carcinomaPleomorphic adenomaPolymorphous adenocarcinoma |
| spellingShingle | Ekarat Phattarataratip Nicha Kositkittiwanit Pruch Kajornkiatkul Pataraporn Yeunyong Ratanatip Ratanapitak P120 catenin expression and its correlation with E-cadherin in salivary gland neoplasms Journal of Oral Biology and Craniofacial Research P120 catenin E-cadherin Mucoepidermoid carcinoma Adenoid cystic carcinoma Pleomorphic adenoma Polymorphous adenocarcinoma |
| title | P120 catenin expression and its correlation with E-cadherin in salivary gland neoplasms |
| title_full | P120 catenin expression and its correlation with E-cadherin in salivary gland neoplasms |
| title_fullStr | P120 catenin expression and its correlation with E-cadherin in salivary gland neoplasms |
| title_full_unstemmed | P120 catenin expression and its correlation with E-cadherin in salivary gland neoplasms |
| title_short | P120 catenin expression and its correlation with E-cadherin in salivary gland neoplasms |
| title_sort | p120 catenin expression and its correlation with e cadherin in salivary gland neoplasms |
| topic | P120 catenin E-cadherin Mucoepidermoid carcinoma Adenoid cystic carcinoma Pleomorphic adenoma Polymorphous adenocarcinoma |
| url | http://www.sciencedirect.com/science/article/pii/S221242681830126X |
| work_keys_str_mv | AT ekaratphattarataratip p120cateninexpressionanditscorrelationwithecadherininsalivaryglandneoplasms AT nichakositkittiwanit p120cateninexpressionanditscorrelationwithecadherininsalivaryglandneoplasms AT pruchkajornkiatkul p120cateninexpressionanditscorrelationwithecadherininsalivaryglandneoplasms AT patarapornyeunyong p120cateninexpressionanditscorrelationwithecadherininsalivaryglandneoplasms AT ratanatipratanapitak p120cateninexpressionanditscorrelationwithecadherininsalivaryglandneoplasms |