DETERMINATION OF ANTIMICROBIAL ACTIVITY OF EXTRACTS OF CALENDULA OFFICINALIS FLOWERS
Pot marigold (Calendula officinalis L.) is one of the most popular medicinal plants in the Russian Federation and abroad. The wide range of pharmacological activity of this medicinal plant is determined by carotenoids, flavonoids, saponins. These biologically active substances give total therapeutic...
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| Format: | Article |
| Language: | Russian |
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Volgograd State Medical University, Pyatigorsk Medical and Pharmaceutical Institute
2016-09-01
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| Series: | Фармация и фармакология (Пятигорск) |
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| Online Access: | https://www.pharmpharm.ru/jour/article/view/197 |
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| author | P. V. Afanasyeva A. V. Kurkina V. A. Kurkin A. V. Lyamin A. V. Zhestkov |
| author_facet | P. V. Afanasyeva A. V. Kurkina V. A. Kurkin A. V. Lyamin A. V. Zhestkov |
| author_sort | P. V. Afanasyeva |
| collection | DOAJ |
| description | Pot marigold (Calendula officinalis L.) is one of the most popular medicinal plants in the Russian Federation and abroad. The wide range of pharmacological activity of this medicinal plant is determined by carotenoids, flavonoids, saponins. These biologically active substances give total therapeutic effect of flowers of Calendula officinalis and medicines on base of pot marigold. This paper discusses the results of comparative investigations for a determination of antimicrobial activity of aqueous and aqueous- alcoholic extracts from pot marigold flowers. Detection of the minimum inhibitory concentration (MIC) was carried out by using the method of double serial dilutions in broth. The following microorganisms were used as test cultures: Bacillus cereus, Candida albicans, Escherichia coli, Pseudomonas aeruginosa and Staphylococcus aureus. The study showed that the widest spectrum of antibacterial activity has water extract of pot marigold flowers. As for Pseudomonas aeruginosa the most active medicine is tincture (1:10) with 70% alcohol. As for Escherichia coli the only phytopharmaceutical – water extract of marigold flowers, reveals antimicrobial activity. Against Bacillus cereus the most effective properties was indicated for tincture (1:5) with 70% ethanol and the liquid extract (1:2) with 70% alcohol. In case of Candida albicans, tincture (1:10) with 70% alcohol exhibited the highest activity. |
| format | Article |
| id | doaj-art-063fd1339c5048bb9e062d4d8f80edd9 |
| institution | Kabale University |
| issn | 2307-9266 2413-2241 |
| language | Russian |
| publishDate | 2016-09-01 |
| publisher | Volgograd State Medical University, Pyatigorsk Medical and Pharmaceutical Institute |
| record_format | Article |
| series | Фармация и фармакология (Пятигорск) |
| spelling | doaj-art-063fd1339c5048bb9e062d4d8f80edd92025-08-20T03:44:10ZrusVolgograd State Medical University, Pyatigorsk Medical and Pharmaceutical InstituteФармация и фармакология (Пятигорск)2307-92662413-22412016-09-0142(15)607010.19163/2307-9266-2016-4-2(15)-60-70195DETERMINATION OF ANTIMICROBIAL ACTIVITY OF EXTRACTS OF CALENDULA OFFICINALIS FLOWERSP. V. Afanasyeva0A. V. Kurkina1V. A. Kurkin2A. V. Lyamin3A. V. Zhestkov4Samara State Medical University, SamaraSamara State Medical University, SamaraSamara State Medical University, SamaraSamara State Medical University, SamaraSamara State Medical University, SamaraPot marigold (Calendula officinalis L.) is one of the most popular medicinal plants in the Russian Federation and abroad. The wide range of pharmacological activity of this medicinal plant is determined by carotenoids, flavonoids, saponins. These biologically active substances give total therapeutic effect of flowers of Calendula officinalis and medicines on base of pot marigold. This paper discusses the results of comparative investigations for a determination of antimicrobial activity of aqueous and aqueous- alcoholic extracts from pot marigold flowers. Detection of the minimum inhibitory concentration (MIC) was carried out by using the method of double serial dilutions in broth. The following microorganisms were used as test cultures: Bacillus cereus, Candida albicans, Escherichia coli, Pseudomonas aeruginosa and Staphylococcus aureus. The study showed that the widest spectrum of antibacterial activity has water extract of pot marigold flowers. As for Pseudomonas aeruginosa the most active medicine is tincture (1:10) with 70% alcohol. As for Escherichia coli the only phytopharmaceutical – water extract of marigold flowers, reveals antimicrobial activity. Against Bacillus cereus the most effective properties was indicated for tincture (1:5) with 70% ethanol and the liquid extract (1:2) with 70% alcohol. In case of Candida albicans, tincture (1:10) with 70% alcohol exhibited the highest activity.https://www.pharmpharm.ru/jour/article/view/197pot marigoldcalendula officinalis l.flowersinfusiontinctureliquid extractantimicrobial activity |
| spellingShingle | P. V. Afanasyeva A. V. Kurkina V. A. Kurkin A. V. Lyamin A. V. Zhestkov DETERMINATION OF ANTIMICROBIAL ACTIVITY OF EXTRACTS OF CALENDULA OFFICINALIS FLOWERS Фармация и фармакология (Пятигорск) pot marigold calendula officinalis l. flowers infusion tincture liquid extract antimicrobial activity |
| title | DETERMINATION OF ANTIMICROBIAL ACTIVITY OF EXTRACTS OF CALENDULA OFFICINALIS FLOWERS |
| title_full | DETERMINATION OF ANTIMICROBIAL ACTIVITY OF EXTRACTS OF CALENDULA OFFICINALIS FLOWERS |
| title_fullStr | DETERMINATION OF ANTIMICROBIAL ACTIVITY OF EXTRACTS OF CALENDULA OFFICINALIS FLOWERS |
| title_full_unstemmed | DETERMINATION OF ANTIMICROBIAL ACTIVITY OF EXTRACTS OF CALENDULA OFFICINALIS FLOWERS |
| title_short | DETERMINATION OF ANTIMICROBIAL ACTIVITY OF EXTRACTS OF CALENDULA OFFICINALIS FLOWERS |
| title_sort | determination of antimicrobial activity of extracts of calendula officinalis flowers |
| topic | pot marigold calendula officinalis l. flowers infusion tincture liquid extract antimicrobial activity |
| url | https://www.pharmpharm.ru/jour/article/view/197 |
| work_keys_str_mv | AT pvafanasyeva determinationofantimicrobialactivityofextractsofcalendulaofficinalisflowers AT avkurkina determinationofantimicrobialactivityofextractsofcalendulaofficinalisflowers AT vakurkin determinationofantimicrobialactivityofextractsofcalendulaofficinalisflowers AT avlyamin determinationofantimicrobialactivityofextractsofcalendulaofficinalisflowers AT avzhestkov determinationofantimicrobialactivityofextractsofcalendulaofficinalisflowers |