Porphyromonas gingivalis deteriorates autism spectrum disorders by disturbing the gut and oral microbiota
Autism spectrum disorder (ASD) significantly impairs socialization and communication, posing a major societal challenge due to limited understanding of its pathogenesis and lack of effective treatments. Recent studies have shown an imbalance in the oral and intestinal microbiota of individuals with...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-08-01
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| Series: | Frontiers in Microbiology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmicb.2025.1579128/full |
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| author | Bosheng Li Yanan Qiao Yongming Li Yongming Li Yongming Li |
| author_facet | Bosheng Li Yanan Qiao Yongming Li Yongming Li Yongming Li |
| author_sort | Bosheng Li |
| collection | DOAJ |
| description | Autism spectrum disorder (ASD) significantly impairs socialization and communication, posing a major societal challenge due to limited understanding of its pathogenesis and lack of effective treatments. Recent studies have shown an imbalance in the oral and intestinal microbiota of individuals with ASD, which may exacerbate ASD symptoms. In this study, we successfully established an ASD mouse model induced by Porphyromonas gingivalis (Pg) solution. Bio-behavioral experiments, including the elevated plus maze test, demonstrated that Pg. induced anxiety-like behaviors in mice. Analysis of oral and intestinal microbiota revealed significant alterations in microbial richness, diversity, and evenness in Pg-treated mice, indicating that Pg. disrupted the normal bacterial community structure and function. Subsequent 16S rRNA sequencing showed increased abundance of amino acid metabolism pathways in Pg-intervened mice, highlighting the close link between bacterial community function and carbohydrate, amino acid, and nucleotide metabolic pathways. These findings provide promising clinical targets for ASD treatment and offer insights into developing new therapeutic strategies. |
| format | Article |
| id | doaj-art-063cdedd63d34d689f10e7ca36d8653e |
| institution | Kabale University |
| issn | 1664-302X |
| language | English |
| publishDate | 2025-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Microbiology |
| spelling | doaj-art-063cdedd63d34d689f10e7ca36d8653e2025-08-20T03:44:27ZengFrontiers Media S.A.Frontiers in Microbiology1664-302X2025-08-011610.3389/fmicb.2025.15791281579128Porphyromonas gingivalis deteriorates autism spectrum disorders by disturbing the gut and oral microbiotaBosheng Li0Yanan Qiao1Yongming Li2Yongming Li3Yongming Li4Shanghai Engineering Research Center of Tooth Restoration and Regeneration, Tongji University, Shanghai, ChinaShanghai Engineering Research Center of Tooth Restoration and Regeneration, Tongji University, Shanghai, ChinaShanghai Engineering Research Center of Tooth Restoration and Regeneration, Tongji University, Shanghai, ChinaTongji Research Institute of Stomatology, Tongji University, Shanghai, ChinaDepartment of Orthodontics, Stomatological Hospital and Dental School, Tongji University, Shanghai, ChinaAutism spectrum disorder (ASD) significantly impairs socialization and communication, posing a major societal challenge due to limited understanding of its pathogenesis and lack of effective treatments. Recent studies have shown an imbalance in the oral and intestinal microbiota of individuals with ASD, which may exacerbate ASD symptoms. In this study, we successfully established an ASD mouse model induced by Porphyromonas gingivalis (Pg) solution. Bio-behavioral experiments, including the elevated plus maze test, demonstrated that Pg. induced anxiety-like behaviors in mice. Analysis of oral and intestinal microbiota revealed significant alterations in microbial richness, diversity, and evenness in Pg-treated mice, indicating that Pg. disrupted the normal bacterial community structure and function. Subsequent 16S rRNA sequencing showed increased abundance of amino acid metabolism pathways in Pg-intervened mice, highlighting the close link between bacterial community function and carbohydrate, amino acid, and nucleotide metabolic pathways. These findings provide promising clinical targets for ASD treatment and offer insights into developing new therapeutic strategies.https://www.frontiersin.org/articles/10.3389/fmicb.2025.1579128/fullPorphyromonas gingivalisautism spectrum disorder16S rRNAintestinal floraoral flora |
| spellingShingle | Bosheng Li Yanan Qiao Yongming Li Yongming Li Yongming Li Porphyromonas gingivalis deteriorates autism spectrum disorders by disturbing the gut and oral microbiota Frontiers in Microbiology Porphyromonas gingivalis autism spectrum disorder 16S rRNA intestinal flora oral flora |
| title | Porphyromonas gingivalis deteriorates autism spectrum disorders by disturbing the gut and oral microbiota |
| title_full | Porphyromonas gingivalis deteriorates autism spectrum disorders by disturbing the gut and oral microbiota |
| title_fullStr | Porphyromonas gingivalis deteriorates autism spectrum disorders by disturbing the gut and oral microbiota |
| title_full_unstemmed | Porphyromonas gingivalis deteriorates autism spectrum disorders by disturbing the gut and oral microbiota |
| title_short | Porphyromonas gingivalis deteriorates autism spectrum disorders by disturbing the gut and oral microbiota |
| title_sort | porphyromonas gingivalis deteriorates autism spectrum disorders by disturbing the gut and oral microbiota |
| topic | Porphyromonas gingivalis autism spectrum disorder 16S rRNA intestinal flora oral flora |
| url | https://www.frontiersin.org/articles/10.3389/fmicb.2025.1579128/full |
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