A study to determine the effect of nano-selenium and thymoquinone on the Nrf2 gene expression in Alzheimer’s disease
Introduction Alzheimer’s disease is a developing public health concern in aging communities that affects a sizable section of the global population. The risk of Alzheimer’s disease increases with age; it affects one-third of males and two-thirds of women. This research attempts to assess the effect...
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Taylor & Francis Group
2025-12-01
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| Series: | Future Science OA |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/20565623.2025.2458434 |
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| author | Doha El-Sayed Ellakwa Laila Ahmed Rashed Ola Sayed Ali Noha Amr El-Sabbagh |
| author_facet | Doha El-Sayed Ellakwa Laila Ahmed Rashed Ola Sayed Ali Noha Amr El-Sabbagh |
| author_sort | Doha El-Sayed Ellakwa |
| collection | DOAJ |
| description | Introduction Alzheimer’s disease is a developing public health concern in aging communities that affects a sizable section of the global population. The risk of Alzheimer’s disease increases with age; it affects one-third of males and two-thirds of women. This research attempts to assess the effect of nano-selenium and thymoquinone on Nrf2 gene expression levels in Alzheimer’s disease (AD).Methods There were five identical groups of 50 albino male rats: a control group that was healthy; an AD positive control group; an AD group that received nano-selenium (5 mg/kg); an AD group that received thymoquinone (2 mg/kg); and an AD group that received both. The duration of treatment was 4 weeks. The levels of Nrf2 in brain tissues were evaluated using real-time PCR.Results Nrf2 mean expression levels in the nano-selenium-treated rats, the thymoquinone-treated rats, and the rats that were given both treatments all increased significantly compared to AD rats with no treatment.Conclusions This study showed that nano-selenium and thymoquinone elevated Nrf2 gene expression levels in AD. |
| format | Article |
| id | doaj-art-0635491d871346f7a0e6fd66a41e6ec8 |
| institution | Kabale University |
| issn | 2056-5623 |
| language | English |
| publishDate | 2025-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Future Science OA |
| spelling | doaj-art-0635491d871346f7a0e6fd66a41e6ec82025-01-31T13:35:38ZengTaylor & Francis GroupFuture Science OA2056-56232025-12-0111110.1080/20565623.2025.2458434A study to determine the effect of nano-selenium and thymoquinone on the Nrf2 gene expression in Alzheimer’s diseaseDoha El-Sayed Ellakwa0Laila Ahmed Rashed1Ola Sayed Ali2Noha Amr El-Sabbagh3Department of Biochemistry and Molecular Biology, Faculty of Pharmacy for Girls, Al-Azhar University, Cairo, EgyptDepartment of Biochemistry, Faculty of Pharmacy, Sinai University, Kantra branch, Ismailia, EgyptDepartment of Biochemistry and Molecular Biology, Faculty of Pharmacy for Girls, Al-Azhar University, Cairo, EgyptDepartment of Biochemistry, Faculty of Dentistry, Future University, Cairo, EgyptIntroduction Alzheimer’s disease is a developing public health concern in aging communities that affects a sizable section of the global population. The risk of Alzheimer’s disease increases with age; it affects one-third of males and two-thirds of women. This research attempts to assess the effect of nano-selenium and thymoquinone on Nrf2 gene expression levels in Alzheimer’s disease (AD).Methods There were five identical groups of 50 albino male rats: a control group that was healthy; an AD positive control group; an AD group that received nano-selenium (5 mg/kg); an AD group that received thymoquinone (2 mg/kg); and an AD group that received both. The duration of treatment was 4 weeks. The levels of Nrf2 in brain tissues were evaluated using real-time PCR.Results Nrf2 mean expression levels in the nano-selenium-treated rats, the thymoquinone-treated rats, and the rats that were given both treatments all increased significantly compared to AD rats with no treatment.Conclusions This study showed that nano-selenium and thymoquinone elevated Nrf2 gene expression levels in AD.https://www.tandfonline.com/doi/10.1080/20565623.2025.2458434Alzheimer’s diseaseneurodegenerationlipopolysaccharidesnano-seleniumnigella sativathymoquinone |
| spellingShingle | Doha El-Sayed Ellakwa Laila Ahmed Rashed Ola Sayed Ali Noha Amr El-Sabbagh A study to determine the effect of nano-selenium and thymoquinone on the Nrf2 gene expression in Alzheimer’s disease Future Science OA Alzheimer’s disease neurodegeneration lipopolysaccharides nano-selenium nigella sativa thymoquinone |
| title | A study to determine the effect of nano-selenium and thymoquinone on the Nrf2 gene expression in Alzheimer’s disease |
| title_full | A study to determine the effect of nano-selenium and thymoquinone on the Nrf2 gene expression in Alzheimer’s disease |
| title_fullStr | A study to determine the effect of nano-selenium and thymoquinone on the Nrf2 gene expression in Alzheimer’s disease |
| title_full_unstemmed | A study to determine the effect of nano-selenium and thymoquinone on the Nrf2 gene expression in Alzheimer’s disease |
| title_short | A study to determine the effect of nano-selenium and thymoquinone on the Nrf2 gene expression in Alzheimer’s disease |
| title_sort | study to determine the effect of nano selenium and thymoquinone on the nrf2 gene expression in alzheimer s disease |
| topic | Alzheimer’s disease neurodegeneration lipopolysaccharides nano-selenium nigella sativa thymoquinone |
| url | https://www.tandfonline.com/doi/10.1080/20565623.2025.2458434 |
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