Chiral‐induced highly efficient NIR–photothermal conversion of perylene diimide@silica nanocapsules for photothermal therapy
Abstract Photothermal agents (PTAs) with ultra‐high photothermal conversion efficiency (PCE) activated upon near‐infrared (NIR) laser irradiation can heat up and destroy tumor cells under low‐intensity laser excitation to allow safe and efficient tumor therapy. Herein, an organic PTA with an outstan...
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2024-12-01
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| Online Access: | https://doi.org/10.1002/agt2.630 |
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| author | Yue Zhao Fuhao An Jichao Wu Haining Li Xueyu Wang Lanya Jiao Ying Kong Jinghan Zhu Xun Sun Xu Li Miao Wang Yu Zhang Xuan Sun |
| author_facet | Yue Zhao Fuhao An Jichao Wu Haining Li Xueyu Wang Lanya Jiao Ying Kong Jinghan Zhu Xun Sun Xu Li Miao Wang Yu Zhang Xuan Sun |
| author_sort | Yue Zhao |
| collection | DOAJ |
| description | Abstract Photothermal agents (PTAs) with ultra‐high photothermal conversion efficiency (PCE) activated upon near‐infrared (NIR) laser irradiation can heat up and destroy tumor cells under low‐intensity laser excitation to allow safe and efficient tumor therapy. Herein, an organic PTA with an outstanding PCE of 89.6% is developed from rationally designed perylene diimide (PDI) with electron‐donating cyclohexylamine moiety at the bay‐positions of its skeleton and chiral phenethylamine (PEA) moiety at its N terminals, termed here PEAPDI. The strong intermolecular interaction between the PDI skeletons induced by PEA together with the intramolecular charge transfer from cyclohexylamine to PDI skeleton severely quenches the fluorescence emission from PEAPDI and significantly enhances its NIR absorption, resulting in super NIR–photothermal conversion. PEAPDI molecules are subsequently encapsulated within silica nanocapsules (SNCs), creating PEAPDI@SNC. Characterized by its small hydrodynamic diameter, monodispersity, high PDI encapsulation efficiency, colloidal stability, and biocompatibility, PEAPDI@SNC exhibits prolonged blood circulation and enhanced permeability and retention effect, enabling targeted accumulation at the tumor site. An in vivo study using a 4T1 tumor–bearing mice model illustrates the agent's potent tumor ablation capability without side effects at low dosage under NIR laser irradiation (808 nm). The findings demonstrate PEAPDI@SNC's significant potential as a PTA for tumor treatment. |
| format | Article |
| id | doaj-art-063503e9b73d406a8ce8d260bd370d0a |
| institution | OA Journals |
| issn | 2692-4560 |
| language | English |
| publishDate | 2024-12-01 |
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| spelling | doaj-art-063503e9b73d406a8ce8d260bd370d0a2025-08-20T01:56:48ZengWileyAggregate2692-45602024-12-0156n/an/a10.1002/agt2.630Chiral‐induced highly efficient NIR–photothermal conversion of perylene diimide@silica nanocapsules for photothermal therapyYue Zhao0Fuhao An1Jichao Wu2Haining Li3Xueyu Wang4Lanya Jiao5Ying Kong6Jinghan Zhu7Xun Sun8Xu Li9Miao Wang10Yu Zhang11Xuan Sun12State Key Laboratory of Crystal Materials Shandong University Jinan ChinaSchool of Chemistry and Chemical Engineering Shandong University Jinan ChinaKey Laboratory of Infection and Immunity of Shandong Province, Department of Pharmacology, School of Basic Medical Sciences Shandong University Jinan ChinaState Key Laboratory of Crystal Materials Shandong University Jinan ChinaSchool of Chemistry and Chemical Engineering Shandong University Jinan ChinaSchool of Chemistry and Chemical Engineering Shandong University Jinan ChinaState Key Laboratory of Crystal Materials Shandong University Jinan ChinaKey Laboratory of Infection and Immunity of Shandong Province, Department of Pharmacology, School of Basic Medical Sciences Shandong University Jinan ChinaState Key Laboratory of Crystal Materials Shandong University Jinan ChinaInstitute of Materials Research and Engineering (IMRE) Agency for Science, Technology and Research (A*STAR) Singapore SingaporeInstitut National de la Recherche Scientifique (INRS), Centre Énergie, Matériaux et Télécommunications Université du Québec Varennes Quebec CanadaInstitute of Sustainability for Chemicals, Energy and Environment (ISCE2) Agency for Science, Technology and Research (A*STAR) Singapore SingaporeSchool of Chemistry and Chemical Engineering Shandong University Jinan ChinaAbstract Photothermal agents (PTAs) with ultra‐high photothermal conversion efficiency (PCE) activated upon near‐infrared (NIR) laser irradiation can heat up and destroy tumor cells under low‐intensity laser excitation to allow safe and efficient tumor therapy. Herein, an organic PTA with an outstanding PCE of 89.6% is developed from rationally designed perylene diimide (PDI) with electron‐donating cyclohexylamine moiety at the bay‐positions of its skeleton and chiral phenethylamine (PEA) moiety at its N terminals, termed here PEAPDI. The strong intermolecular interaction between the PDI skeletons induced by PEA together with the intramolecular charge transfer from cyclohexylamine to PDI skeleton severely quenches the fluorescence emission from PEAPDI and significantly enhances its NIR absorption, resulting in super NIR–photothermal conversion. PEAPDI molecules are subsequently encapsulated within silica nanocapsules (SNCs), creating PEAPDI@SNC. Characterized by its small hydrodynamic diameter, monodispersity, high PDI encapsulation efficiency, colloidal stability, and biocompatibility, PEAPDI@SNC exhibits prolonged blood circulation and enhanced permeability and retention effect, enabling targeted accumulation at the tumor site. An in vivo study using a 4T1 tumor–bearing mice model illustrates the agent's potent tumor ablation capability without side effects at low dosage under NIR laser irradiation (808 nm). The findings demonstrate PEAPDI@SNC's significant potential as a PTA for tumor treatment.https://doi.org/10.1002/agt2.630aggregationchiralNIR–photothermal conversionperylene diimidephotothermal therapy |
| spellingShingle | Yue Zhao Fuhao An Jichao Wu Haining Li Xueyu Wang Lanya Jiao Ying Kong Jinghan Zhu Xun Sun Xu Li Miao Wang Yu Zhang Xuan Sun Chiral‐induced highly efficient NIR–photothermal conversion of perylene diimide@silica nanocapsules for photothermal therapy Aggregate aggregation chiral NIR–photothermal conversion perylene diimide photothermal therapy |
| title | Chiral‐induced highly efficient NIR–photothermal conversion of perylene diimide@silica nanocapsules for photothermal therapy |
| title_full | Chiral‐induced highly efficient NIR–photothermal conversion of perylene diimide@silica nanocapsules for photothermal therapy |
| title_fullStr | Chiral‐induced highly efficient NIR–photothermal conversion of perylene diimide@silica nanocapsules for photothermal therapy |
| title_full_unstemmed | Chiral‐induced highly efficient NIR–photothermal conversion of perylene diimide@silica nanocapsules for photothermal therapy |
| title_short | Chiral‐induced highly efficient NIR–photothermal conversion of perylene diimide@silica nanocapsules for photothermal therapy |
| title_sort | chiral induced highly efficient nir photothermal conversion of perylene diimide silica nanocapsules for photothermal therapy |
| topic | aggregation chiral NIR–photothermal conversion perylene diimide photothermal therapy |
| url | https://doi.org/10.1002/agt2.630 |
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