CLINICAL AND IMMUNOLOGICAL FEATURES OF KIDNEY TRANSPLANT RECIPIENTS WITH CYTOMEGALOVIRUS INFECTION MANIFESTATION IN THE EARLY POSTOPERATIVE PERIOD
Aim. To optimize the management of postoperative renal allograft recipients through the introduction of methods for predicting risk of manifestation of cytomegalovirus infection on the basis of a comprehensive assessment of the clinical and immunological status. Materials and methods. We retrospecti...
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Federal Research Center of Transplantology and Artificial Organs named after V.I.Shumakov
2014-05-01
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| Series: | Вестник трансплантологии и искусственных органов |
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| Online Access: | https://journal.transpl.ru/vtio/article/view/77 |
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| author | L. V. Limareva A. V. Kolsanov A. A. Avdeeva O. P. Danilchenko W. V. Bogush |
| author_facet | L. V. Limareva A. V. Kolsanov A. A. Avdeeva O. P. Danilchenko W. V. Bogush |
| author_sort | L. V. Limareva |
| collection | DOAJ |
| description | Aim. To optimize the management of postoperative renal allograft recipients through the introduction of methods for predicting risk of manifestation of cytomegalovirus infection on the basis of a comprehensive assessment of the clinical and immunological status. Materials and methods. We retrospectively analyzed the medical records of 303 patients with end-stage renal disease, among them – were the recipients of renal allograft – 136, among whom 29 within 2 months after the operation had clinical signs of CMV infection. Assessable "CMV syndrome", laboratory evidence of CMV infection, the incidence of antigens (genes) of HLA A, B and DRB *1, calculated goodness of fit χ2 and relative risk RR, changes MCP-1 in urine. Results. In renal allograft recipients with clinical and laboratory evidence of CMV infection in the early postoperative period, significantly more (χ2 > 3,8) met antigen B35. A positive association with CMV infection was detected also for DRB1 * 08, B21, B22, B41, A24 (9), B51 (5), DRB1*14 and DRB1*15. Protective effects possessed antigens / alleles of genes A26 (10), B14, B38 (16) B61 (40) and DRB1*16. MCP-1 levels in this group of recipients were raised to 2174,7 ± 296,3 pg/ml with a strong negative correlation with the levels of urea and creatinine in serum (r = 0,9, p < 0.001). Conclusion. Immunological markers of risk manifestation of CMV infection in recipients of kidneys in the early postoperative period are: the carriage of В35 и В55,56(22), В49(21), В41, DRB1*08 и DRB1*15, an increase of levels of MCP-1 in urine without increasing the levels of urea and creatinine in the serum. |
| format | Article |
| id | doaj-art-06322e063b6d43b791cc5019d97dbee7 |
| institution | DOAJ |
| issn | 1995-1191 |
| language | Russian |
| publishDate | 2014-05-01 |
| publisher | Federal Research Center of Transplantology and Artificial Organs named after V.I.Shumakov |
| record_format | Article |
| series | Вестник трансплантологии и искусственных органов |
| spelling | doaj-art-06322e063b6d43b791cc5019d97dbee72025-08-20T03:01:23ZrusFederal Research Center of Transplantology and Artificial Organs named after V.I.ShumakovВестник трансплантологии и искусственных органов1995-11912014-05-01154243010.15825/1995-1191-2013-4-24-3020CLINICAL AND IMMUNOLOGICAL FEATURES OF KIDNEY TRANSPLANT RECIPIENTS WITH CYTOMEGALOVIRUS INFECTION MANIFESTATION IN THE EARLY POSTOPERATIVE PERIODL. V. Limareva0A. V. Kolsanov1A. A. Avdeeva2O. P. Danilchenko3W. V. Bogush4Institute of experimental medecine and biotechnology (direktor – prof. L.T. Volova) Samara state medical University (rector – academician of RAMSci, prof. G.P. Kotelnikov), Samara, Russian FederationChair of operative surgery and clinical anatomy with a course of innovatine technologies (Head – prof. A.V. Kolsanov) of the same UniversityDepartment organ transplantation (Head – prof. I.I. Losev) at the same University, Russian FederationInstitute of experimental medecine and biotechnology (direktor – prof. L.T. Volova) Samara state medical University (rector – academician of RAMSci, prof. G.P. Kotelnikov), Samara, Russian FederationInstitute of experimental medecine and biotechnology (direktor – prof. L.T. Volova) Samara state medical University (rector – academician of RAMSci, prof. G.P. Kotelnikov), Samara, Russian FederationAim. To optimize the management of postoperative renal allograft recipients through the introduction of methods for predicting risk of manifestation of cytomegalovirus infection on the basis of a comprehensive assessment of the clinical and immunological status. Materials and methods. We retrospectively analyzed the medical records of 303 patients with end-stage renal disease, among them – were the recipients of renal allograft – 136, among whom 29 within 2 months after the operation had clinical signs of CMV infection. Assessable "CMV syndrome", laboratory evidence of CMV infection, the incidence of antigens (genes) of HLA A, B and DRB *1, calculated goodness of fit χ2 and relative risk RR, changes MCP-1 in urine. Results. In renal allograft recipients with clinical and laboratory evidence of CMV infection in the early postoperative period, significantly more (χ2 > 3,8) met antigen B35. A positive association with CMV infection was detected also for DRB1 * 08, B21, B22, B41, A24 (9), B51 (5), DRB1*14 and DRB1*15. Protective effects possessed antigens / alleles of genes A26 (10), B14, B38 (16) B61 (40) and DRB1*16. MCP-1 levels in this group of recipients were raised to 2174,7 ± 296,3 pg/ml with a strong negative correlation with the levels of urea and creatinine in serum (r = 0,9, p < 0.001). Conclusion. Immunological markers of risk manifestation of CMV infection in recipients of kidneys in the early postoperative period are: the carriage of В35 и В55,56(22), В49(21), В41, DRB1*08 и DRB1*15, an increase of levels of MCP-1 in urine without increasing the levels of urea and creatinine in the serum.https://journal.transpl.ru/vtio/article/view/77kidney transplantation, cytomegalovirus infection, hla-system, immune status, мср-1 |
| spellingShingle | L. V. Limareva A. V. Kolsanov A. A. Avdeeva O. P. Danilchenko W. V. Bogush CLINICAL AND IMMUNOLOGICAL FEATURES OF KIDNEY TRANSPLANT RECIPIENTS WITH CYTOMEGALOVIRUS INFECTION MANIFESTATION IN THE EARLY POSTOPERATIVE PERIOD Вестник трансплантологии и искусственных органов kidney transplantation, cytomegalovirus infection, hla-system, immune status, мср-1 |
| title | CLINICAL AND IMMUNOLOGICAL FEATURES OF KIDNEY TRANSPLANT RECIPIENTS WITH CYTOMEGALOVIRUS INFECTION MANIFESTATION IN THE EARLY POSTOPERATIVE PERIOD |
| title_full | CLINICAL AND IMMUNOLOGICAL FEATURES OF KIDNEY TRANSPLANT RECIPIENTS WITH CYTOMEGALOVIRUS INFECTION MANIFESTATION IN THE EARLY POSTOPERATIVE PERIOD |
| title_fullStr | CLINICAL AND IMMUNOLOGICAL FEATURES OF KIDNEY TRANSPLANT RECIPIENTS WITH CYTOMEGALOVIRUS INFECTION MANIFESTATION IN THE EARLY POSTOPERATIVE PERIOD |
| title_full_unstemmed | CLINICAL AND IMMUNOLOGICAL FEATURES OF KIDNEY TRANSPLANT RECIPIENTS WITH CYTOMEGALOVIRUS INFECTION MANIFESTATION IN THE EARLY POSTOPERATIVE PERIOD |
| title_short | CLINICAL AND IMMUNOLOGICAL FEATURES OF KIDNEY TRANSPLANT RECIPIENTS WITH CYTOMEGALOVIRUS INFECTION MANIFESTATION IN THE EARLY POSTOPERATIVE PERIOD |
| title_sort | clinical and immunological features of kidney transplant recipients with cytomegalovirus infection manifestation in the early postoperative period |
| topic | kidney transplantation, cytomegalovirus infection, hla-system, immune status, мср-1 |
| url | https://journal.transpl.ru/vtio/article/view/77 |
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