Magnitude of Malaria-Typhoid Fever Coinfection in Febrile Patients at Arba Minch General Hospital in Southern Ethiopia
Background. Coinfection with malaria and typhoid fever is a major public health issue in developing countries. In endemic areas, including Ethiopia, people are at risk of acquiring both malaria and typhoid fever at the same time. Therefore, this study aimed to determine the magnitude of malaria-typh...
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| Format: | Article |
| Language: | English |
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Wiley
2022-01-01
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| Series: | Journal of Tropical Medicine |
| Online Access: | http://dx.doi.org/10.1155/2022/2165980 |
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| author | Sifray Batire Tsegaye Yohanes Dagimawie Tadesse Melat Woldemariam Befikadu Tariku Zebenay Sanbeto Debalke Dale Dagninet Alelign |
| author_facet | Sifray Batire Tsegaye Yohanes Dagimawie Tadesse Melat Woldemariam Befikadu Tariku Zebenay Sanbeto Debalke Dale Dagninet Alelign |
| author_sort | Sifray Batire |
| collection | DOAJ |
| description | Background. Coinfection with malaria and typhoid fever is a major public health issue in developing countries. In endemic areas, including Ethiopia, people are at risk of acquiring both malaria and typhoid fever at the same time. Therefore, this study aimed to determine the magnitude of malaria-typhoid fever coinfection in febrile patients attending hospital at Southern Ethiopia. Methods. A hospital-based cross-sectional study was carried out on 416 febrile patients attending Arba Minch General Hospital from 1st October to 30th December 2021. The data was collected using a pretested structured questionnaire. Capillary and Venus blood samples were collected for assessing malaria and typhoid fever, respectively. Blood smear, culture, and biochemical tests were performed based on standard parasitological and microbiological methods. The P-value ≤ 0.05 was considered statistically significant. Results. The magnitude of malaria, typhoid fever, and their coinfections was 26.2% (109/416), 6.5% (27/416), and 3.1% (13/416), respectively. Among the confirmed malaria cases, about 66% of infections were Plasmodium falciparum. The malaria-typhoid fever coinfection showed a statistically significant association with a clinical presentation of a continuous pattern of fever (AOR = 5.84; 95% CI: 1.44–23.71, P=0.014) and chills (AOR = 3.94; 95% CI: 1.04–14.89, P=0.044). About 29.6% of Salmonella isolates were multidrug-resistant (MDR). Conclusion. The total rate of coinfection with malaria and typhoid fever was comparable to that of previous studies. With the consideration of higher prevalence of drug resistance of Salmonella spp. and higher prevalence of malaria‐typhoid fever coinfection, proper diagnostic procedure should be implemented for proper use of drugs. |
| format | Article |
| id | doaj-art-0631e6b9f783494ab86019af3a3d1715 |
| institution | OA Journals |
| issn | 1687-9694 |
| language | English |
| publishDate | 2022-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Tropical Medicine |
| spelling | doaj-art-0631e6b9f783494ab86019af3a3d17152025-08-20T02:03:42ZengWileyJournal of Tropical Medicine1687-96942022-01-01202210.1155/2022/2165980Magnitude of Malaria-Typhoid Fever Coinfection in Febrile Patients at Arba Minch General Hospital in Southern EthiopiaSifray Batire0Tsegaye Yohanes1Dagimawie Tadesse2Melat Woldemariam3Befikadu Tariku4Zebenay Sanbeto5Debalke Dale6Dagninet Alelign7Department of Medical Laboratory ScienceDepartment of Medical Laboratory ScienceDepartment of Medical Laboratory ScienceDepartment of Medical Laboratory ScienceSchool of Public HealthDepartment of PharmacyDepartment of PharmacyDepartment of Medical Laboratory ScienceBackground. Coinfection with malaria and typhoid fever is a major public health issue in developing countries. In endemic areas, including Ethiopia, people are at risk of acquiring both malaria and typhoid fever at the same time. Therefore, this study aimed to determine the magnitude of malaria-typhoid fever coinfection in febrile patients attending hospital at Southern Ethiopia. Methods. A hospital-based cross-sectional study was carried out on 416 febrile patients attending Arba Minch General Hospital from 1st October to 30th December 2021. The data was collected using a pretested structured questionnaire. Capillary and Venus blood samples were collected for assessing malaria and typhoid fever, respectively. Blood smear, culture, and biochemical tests were performed based on standard parasitological and microbiological methods. The P-value ≤ 0.05 was considered statistically significant. Results. The magnitude of malaria, typhoid fever, and their coinfections was 26.2% (109/416), 6.5% (27/416), and 3.1% (13/416), respectively. Among the confirmed malaria cases, about 66% of infections were Plasmodium falciparum. The malaria-typhoid fever coinfection showed a statistically significant association with a clinical presentation of a continuous pattern of fever (AOR = 5.84; 95% CI: 1.44–23.71, P=0.014) and chills (AOR = 3.94; 95% CI: 1.04–14.89, P=0.044). About 29.6% of Salmonella isolates were multidrug-resistant (MDR). Conclusion. The total rate of coinfection with malaria and typhoid fever was comparable to that of previous studies. With the consideration of higher prevalence of drug resistance of Salmonella spp. and higher prevalence of malaria‐typhoid fever coinfection, proper diagnostic procedure should be implemented for proper use of drugs.http://dx.doi.org/10.1155/2022/2165980 |
| spellingShingle | Sifray Batire Tsegaye Yohanes Dagimawie Tadesse Melat Woldemariam Befikadu Tariku Zebenay Sanbeto Debalke Dale Dagninet Alelign Magnitude of Malaria-Typhoid Fever Coinfection in Febrile Patients at Arba Minch General Hospital in Southern Ethiopia Journal of Tropical Medicine |
| title | Magnitude of Malaria-Typhoid Fever Coinfection in Febrile Patients at Arba Minch General Hospital in Southern Ethiopia |
| title_full | Magnitude of Malaria-Typhoid Fever Coinfection in Febrile Patients at Arba Minch General Hospital in Southern Ethiopia |
| title_fullStr | Magnitude of Malaria-Typhoid Fever Coinfection in Febrile Patients at Arba Minch General Hospital in Southern Ethiopia |
| title_full_unstemmed | Magnitude of Malaria-Typhoid Fever Coinfection in Febrile Patients at Arba Minch General Hospital in Southern Ethiopia |
| title_short | Magnitude of Malaria-Typhoid Fever Coinfection in Febrile Patients at Arba Minch General Hospital in Southern Ethiopia |
| title_sort | magnitude of malaria typhoid fever coinfection in febrile patients at arba minch general hospital in southern ethiopia |
| url | http://dx.doi.org/10.1155/2022/2165980 |
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