Multiplex Tests for Respiratory Tract Infections: The Direct Utility of the FilmArray Respiratory Panel in Emergency Department
Background. The FilmArray Respiratory Panel with multiplex targets for respiratory pathogens has been widely used and verified in clinical trials in special test settings. However, it is necessary to evaluate the panel’s performance at the point of care directly, in nonspecific test settings. Method...
Saved in:
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2020-01-01
|
| Series: | Canadian Respiratory Journal |
| Online Access: | http://dx.doi.org/10.1155/2020/6014563 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832566316395921408 |
|---|---|
| author | Siyuan Yang Hui Li Yunxia Tang Fengting Yu Chengjie Ma Huimin Zhang Lin Pang Hongxin Zhao Linghang Wang |
| author_facet | Siyuan Yang Hui Li Yunxia Tang Fengting Yu Chengjie Ma Huimin Zhang Lin Pang Hongxin Zhao Linghang Wang |
| author_sort | Siyuan Yang |
| collection | DOAJ |
| description | Background. The FilmArray Respiratory Panel with multiplex targets for respiratory pathogens has been widely used and verified in clinical trials in special test settings. However, it is necessary to evaluate the panel’s performance at the point of care directly, in nonspecific test settings. Methods. Patients with respiratory tract infections were enrolled from among emergency department visitors, and all steps, including the collection of specimens and testing, were performed by our clinicians. Results. Among 270 patients, 196 (72.6%) patients were found to have one or more pathogens. For signal pathogen detection, influenza A virus had the highest rate of detection; 45 (16.7%) of the patients had two or more respiratory pathogens codetected, and most of the multiplex pathogens were rhinovirus/enterovirus codetected with Bordetella pertussis (17.8%). The information provided by the FilmArray had an impact on the prescription of antimicrobials, and there were differences in the rates of antibiotic prescriptions and anti-influenza prescriptions among patients. Conclusions. Use of the FilmArray by clinical staff was successfully implemented in the emergency department for the first time in China. The FilmArray has the potential for point-of-care testing in nonspecific settings. |
| format | Article |
| id | doaj-art-062a58792d3540e2b3c329956aaeb127 |
| institution | Kabale University |
| issn | 1198-2241 1916-7245 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Canadian Respiratory Journal |
| spelling | doaj-art-062a58792d3540e2b3c329956aaeb1272025-02-03T01:04:28ZengWileyCanadian Respiratory Journal1198-22411916-72452020-01-01202010.1155/2020/60145636014563Multiplex Tests for Respiratory Tract Infections: The Direct Utility of the FilmArray Respiratory Panel in Emergency DepartmentSiyuan Yang0Hui Li1Yunxia Tang2Fengting Yu3Chengjie Ma4Huimin Zhang5Lin Pang6Hongxin Zhao7Linghang Wang8Laboratory of Infectious Diseases Center of Beijing Ditan Hospital, Capital Medical University, Beijing 10015, ChinaEmergency Department of Infectious Diseases of Beijing Ditan Hospital, Capital Medical University, Beijing 10015, ChinaLaboratory of Infectious Diseases Center of Beijing Ditan Hospital, Capital Medical University, Beijing 10015, ChinaLaboratory of Infectious Diseases Center of Beijing Ditan Hospital, Capital Medical University, Beijing 10015, ChinaLaboratory of Infectious Diseases Center of Beijing Ditan Hospital, Capital Medical University, Beijing 10015, ChinaDepartment of Pediatrics of Beijing Ditan Hospital, Capital Medical University, Beijing 10015, ChinaDepartment of Pediatrics of Beijing Ditan Hospital, Capital Medical University, Beijing 10015, ChinaClinical and Research Center of Infectious Diseases of Beijing Ditan Hospital, Capital Medical University, Beijing 10015, ChinaLaboratory of Infectious Diseases Center of Beijing Ditan Hospital, Capital Medical University, Beijing 10015, ChinaBackground. The FilmArray Respiratory Panel with multiplex targets for respiratory pathogens has been widely used and verified in clinical trials in special test settings. However, it is necessary to evaluate the panel’s performance at the point of care directly, in nonspecific test settings. Methods. Patients with respiratory tract infections were enrolled from among emergency department visitors, and all steps, including the collection of specimens and testing, were performed by our clinicians. Results. Among 270 patients, 196 (72.6%) patients were found to have one or more pathogens. For signal pathogen detection, influenza A virus had the highest rate of detection; 45 (16.7%) of the patients had two or more respiratory pathogens codetected, and most of the multiplex pathogens were rhinovirus/enterovirus codetected with Bordetella pertussis (17.8%). The information provided by the FilmArray had an impact on the prescription of antimicrobials, and there were differences in the rates of antibiotic prescriptions and anti-influenza prescriptions among patients. Conclusions. Use of the FilmArray by clinical staff was successfully implemented in the emergency department for the first time in China. The FilmArray has the potential for point-of-care testing in nonspecific settings.http://dx.doi.org/10.1155/2020/6014563 |
| spellingShingle | Siyuan Yang Hui Li Yunxia Tang Fengting Yu Chengjie Ma Huimin Zhang Lin Pang Hongxin Zhao Linghang Wang Multiplex Tests for Respiratory Tract Infections: The Direct Utility of the FilmArray Respiratory Panel in Emergency Department Canadian Respiratory Journal |
| title | Multiplex Tests for Respiratory Tract Infections: The Direct Utility of the FilmArray Respiratory Panel in Emergency Department |
| title_full | Multiplex Tests for Respiratory Tract Infections: The Direct Utility of the FilmArray Respiratory Panel in Emergency Department |
| title_fullStr | Multiplex Tests for Respiratory Tract Infections: The Direct Utility of the FilmArray Respiratory Panel in Emergency Department |
| title_full_unstemmed | Multiplex Tests for Respiratory Tract Infections: The Direct Utility of the FilmArray Respiratory Panel in Emergency Department |
| title_short | Multiplex Tests for Respiratory Tract Infections: The Direct Utility of the FilmArray Respiratory Panel in Emergency Department |
| title_sort | multiplex tests for respiratory tract infections the direct utility of the filmarray respiratory panel in emergency department |
| url | http://dx.doi.org/10.1155/2020/6014563 |
| work_keys_str_mv | AT siyuanyang multiplextestsforrespiratorytractinfectionsthedirectutilityofthefilmarrayrespiratorypanelinemergencydepartment AT huili multiplextestsforrespiratorytractinfectionsthedirectutilityofthefilmarrayrespiratorypanelinemergencydepartment AT yunxiatang multiplextestsforrespiratorytractinfectionsthedirectutilityofthefilmarrayrespiratorypanelinemergencydepartment AT fengtingyu multiplextestsforrespiratorytractinfectionsthedirectutilityofthefilmarrayrespiratorypanelinemergencydepartment AT chengjiema multiplextestsforrespiratorytractinfectionsthedirectutilityofthefilmarrayrespiratorypanelinemergencydepartment AT huiminzhang multiplextestsforrespiratorytractinfectionsthedirectutilityofthefilmarrayrespiratorypanelinemergencydepartment AT linpang multiplextestsforrespiratorytractinfectionsthedirectutilityofthefilmarrayrespiratorypanelinemergencydepartment AT hongxinzhao multiplextestsforrespiratorytractinfectionsthedirectutilityofthefilmarrayrespiratorypanelinemergencydepartment AT linghangwang multiplextestsforrespiratorytractinfectionsthedirectutilityofthefilmarrayrespiratorypanelinemergencydepartment |