Combined effect of areca nut, cigarettes, alcohol and SNPs in glycosyltransferase family genes on lung cancer development in Hainan, China
Abstract Background Abnormal glycosylation modification is closely related to the development and metastasis of cancers. As a carcinogen by the International Agency for Research on Cancer (IARC) of the WHO, areca nut lacked of combined effect’ study with genetic factors related to lung cancer. The a...
Saved in:
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2025-04-01
|
| Series: | BMC Cancer |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12885-025-14088-x |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850206401315471360 |
|---|---|
| author | Shicheng Kuang Sha Xiao Jing Zhou Lirong Liu Na Li Yipeng Ding Pengfei Lyu Chaoyong Zhu Ping Xue |
| author_facet | Shicheng Kuang Sha Xiao Jing Zhou Lirong Liu Na Li Yipeng Ding Pengfei Lyu Chaoyong Zhu Ping Xue |
| author_sort | Shicheng Kuang |
| collection | DOAJ |
| description | Abstract Background Abnormal glycosylation modification is closely related to the development and metastasis of cancers. As a carcinogen by the International Agency for Research on Cancer (IARC) of the WHO, areca nut lacked of combined effect’ study with genetic factors related to lung cancer. The aim of this study was to investigate the combined effect of polymorphisms of glycosyltransferase family genes and behavioral factors on the susceptibility of lung cancer. Methods A case‒control study was conducted in Hainan, which included 428 patients with lung cancer and 428 cancer-free controls. Six single-nucleotide polymorphisms (SNPs) (FUT2 rs1047781, rs601338, FUT3 rs28362459, rs3745635, ST6Gal-I rs2239611 and MGAT5 rs34944508) were detected by the MassARRAY System. The association between these SNPs and the risk of lung cancer, clinicopathological characteristics, and combined effect of behavioral factors (areca nuts, cigarettes, alcohol) and genotypes on lung cancer were estimated using by logistic regression analysis. Results In this study, individuals with AA genotype in ST6Gal-I rs2239611 significantly increased lung cancer risk (ORadj = 2.077; 95%CI:1.191–3.624; P adj = 0.010), particularly in smokers (P adj = 0.038) and alcohol consumers (P adj = 0.049). FUT2 rs1047781 was associated with clinical stage (P adj = 0.047) and lymph node metastasis (P adj = 0.014). Significant gene-environment interactions were observed between behavioral factors (cigarette smoking, alcohol drinking, and betel quid chewing) and both FUT2 rs1047781 (P adj = 0.013) and ST6Gal-I rs2239611 (P adj = 0.047), collectively elevating lung cancer risk. Conclusion ST6Gal-I rs2239611 was a potential genetic biomarker for lung cancer. Areca nut chewing, cigarette smoking, alcohol drinking interacts with glycosyltransferase gene polymorphisms (FUT2 rs1047781 and ST6Gal-I rs2239611), increasing lung cancer risk—a novel finding given the lack of prior studies on this combination. |
| format | Article |
| id | doaj-art-0629200fcb2544b4a59d593ddf9a6eef |
| institution | OA Journals |
| issn | 1471-2407 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Cancer |
| spelling | doaj-art-0629200fcb2544b4a59d593ddf9a6eef2025-08-20T02:10:50ZengBMCBMC Cancer1471-24072025-04-0125111110.1186/s12885-025-14088-xCombined effect of areca nut, cigarettes, alcohol and SNPs in glycosyltransferase family genes on lung cancer development in Hainan, ChinaShicheng Kuang0Sha Xiao1Jing Zhou2Lirong Liu3Na Li4Yipeng Ding5Pengfei Lyu6Chaoyong Zhu7Ping Xue8Department of Pharmacy, Hainan General Hospital, Hainan Affiliated Hospital of Hainan Medical UniversitySchool of Public Health, Key Laboratory of Tropical Translational Medicine of Ministry of Education, Hainan Medical UniversitySchool of Public Health, Key Laboratory of Tropical Translational Medicine of Ministry of Education, Hainan Medical UniversityDepartment of Respiratory and Critical Care Medicine, Hainan General Hospital, Hainan Affiliated Hospital of Hainan Medical UniversitySchool of Public Health, Key Laboratory of Tropical Translational Medicine of Ministry of Education, Hainan Medical UniversityDepartment of Respiratory and Critical Care Medicine, Hainan General Hospital, Hainan Affiliated Hospital of Hainan Medical UniversityDepartment of Breast Surgery, the First Affiliated Hospital of Hainan Medical UniversityMedical Examination Center of Hainan General Hospital, Hainan Affiliated Hospital of Hainan Medical UniversitySchool of Public Health, Shenyang Medical CollegeAbstract Background Abnormal glycosylation modification is closely related to the development and metastasis of cancers. As a carcinogen by the International Agency for Research on Cancer (IARC) of the WHO, areca nut lacked of combined effect’ study with genetic factors related to lung cancer. The aim of this study was to investigate the combined effect of polymorphisms of glycosyltransferase family genes and behavioral factors on the susceptibility of lung cancer. Methods A case‒control study was conducted in Hainan, which included 428 patients with lung cancer and 428 cancer-free controls. Six single-nucleotide polymorphisms (SNPs) (FUT2 rs1047781, rs601338, FUT3 rs28362459, rs3745635, ST6Gal-I rs2239611 and MGAT5 rs34944508) were detected by the MassARRAY System. The association between these SNPs and the risk of lung cancer, clinicopathological characteristics, and combined effect of behavioral factors (areca nuts, cigarettes, alcohol) and genotypes on lung cancer were estimated using by logistic regression analysis. Results In this study, individuals with AA genotype in ST6Gal-I rs2239611 significantly increased lung cancer risk (ORadj = 2.077; 95%CI:1.191–3.624; P adj = 0.010), particularly in smokers (P adj = 0.038) and alcohol consumers (P adj = 0.049). FUT2 rs1047781 was associated with clinical stage (P adj = 0.047) and lymph node metastasis (P adj = 0.014). Significant gene-environment interactions were observed between behavioral factors (cigarette smoking, alcohol drinking, and betel quid chewing) and both FUT2 rs1047781 (P adj = 0.013) and ST6Gal-I rs2239611 (P adj = 0.047), collectively elevating lung cancer risk. Conclusion ST6Gal-I rs2239611 was a potential genetic biomarker for lung cancer. Areca nut chewing, cigarette smoking, alcohol drinking interacts with glycosyltransferase gene polymorphisms (FUT2 rs1047781 and ST6Gal-I rs2239611), increasing lung cancer risk—a novel finding given the lack of prior studies on this combination.https://doi.org/10.1186/s12885-025-14088-xLung cancerSingle-nucleotide polymorphismsAreca nutCigarettesAlcoholST6Gal-I |
| spellingShingle | Shicheng Kuang Sha Xiao Jing Zhou Lirong Liu Na Li Yipeng Ding Pengfei Lyu Chaoyong Zhu Ping Xue Combined effect of areca nut, cigarettes, alcohol and SNPs in glycosyltransferase family genes on lung cancer development in Hainan, China BMC Cancer Lung cancer Single-nucleotide polymorphisms Areca nut Cigarettes Alcohol ST6Gal-I |
| title | Combined effect of areca nut, cigarettes, alcohol and SNPs in glycosyltransferase family genes on lung cancer development in Hainan, China |
| title_full | Combined effect of areca nut, cigarettes, alcohol and SNPs in glycosyltransferase family genes on lung cancer development in Hainan, China |
| title_fullStr | Combined effect of areca nut, cigarettes, alcohol and SNPs in glycosyltransferase family genes on lung cancer development in Hainan, China |
| title_full_unstemmed | Combined effect of areca nut, cigarettes, alcohol and SNPs in glycosyltransferase family genes on lung cancer development in Hainan, China |
| title_short | Combined effect of areca nut, cigarettes, alcohol and SNPs in glycosyltransferase family genes on lung cancer development in Hainan, China |
| title_sort | combined effect of areca nut cigarettes alcohol and snps in glycosyltransferase family genes on lung cancer development in hainan china |
| topic | Lung cancer Single-nucleotide polymorphisms Areca nut Cigarettes Alcohol ST6Gal-I |
| url | https://doi.org/10.1186/s12885-025-14088-x |
| work_keys_str_mv | AT shichengkuang combinedeffectofarecanutcigarettesalcoholandsnpsinglycosyltransferasefamilygenesonlungcancerdevelopmentinhainanchina AT shaxiao combinedeffectofarecanutcigarettesalcoholandsnpsinglycosyltransferasefamilygenesonlungcancerdevelopmentinhainanchina AT jingzhou combinedeffectofarecanutcigarettesalcoholandsnpsinglycosyltransferasefamilygenesonlungcancerdevelopmentinhainanchina AT lirongliu combinedeffectofarecanutcigarettesalcoholandsnpsinglycosyltransferasefamilygenesonlungcancerdevelopmentinhainanchina AT nali combinedeffectofarecanutcigarettesalcoholandsnpsinglycosyltransferasefamilygenesonlungcancerdevelopmentinhainanchina AT yipengding combinedeffectofarecanutcigarettesalcoholandsnpsinglycosyltransferasefamilygenesonlungcancerdevelopmentinhainanchina AT pengfeilyu combinedeffectofarecanutcigarettesalcoholandsnpsinglycosyltransferasefamilygenesonlungcancerdevelopmentinhainanchina AT chaoyongzhu combinedeffectofarecanutcigarettesalcoholandsnpsinglycosyltransferasefamilygenesonlungcancerdevelopmentinhainanchina AT pingxue combinedeffectofarecanutcigarettesalcoholandsnpsinglycosyltransferasefamilygenesonlungcancerdevelopmentinhainanchina |