Acellular, bioresorbable, ultra-purified alginate gel implantation for intervertebral disc herniation: Phase 1/2, open-label, non-randomized clinical trials

Acellular, bioresorbable, ultra-purified alginate gel implantation for intervertebral disc herniation: Phase 1/2, open-label, non-randomized clinical trials

Abstract Discectomy is the current surgical procedure for lumbar intervertebral disc (IVD) herniation. Discectomy was performed to remove the IVD material and relieve the pain inflicted by nerve root compression and axonotoxic effects, such as inflammatory cytokines in the IVD material; however, def...

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Main Authors: Katsuhisa Yamada, Takahiko Hyakumachi, Terufumi Kokabu, Kenichiro Maeda, Toshiyuki Isoe, Khin Khin Tha, Yoichi M. Ito, Takashi Ohnishi, Tsutomu Endo, Daisuke Ukeba, Hiroyuki Tachi, Yuichiro Abe, Yoko Ishikawa, Nozomi Yokota, Takashi Miyakoshi, Osamu Sugita, Norihiro Sato, Norimasa Iwasaki, Hideki Sudo
Format: Article
Language:English
Published: Nature Portfolio 2025-05-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-59715-0
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