Microglia-mediated inflammation and synaptic pruning contribute to sleep deprivation-induced mania in a sex-specific manner

Microglia-mediated inflammation and synaptic pruning contribute to sleep deprivation-induced mania in a sex-specific manner

Abstract Sleep loss is a key trigger for a manic episode of bipolar disorder (BD), but the underlying microglial and molecular mechanisms remain unclear. Sleep loss induces microglial and inflammatory responses. Microglia, resident macrophages in the central nervous system, regulate synaptic pruning...

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Bibliographic Details
Main Authors: Rong-Jun Ni, Wei-Jun Yuan, Yi-Yan Wang, Xiao Yang, Jin-Xue Wei, Lian-Sheng Zhao, Qiang Wang, Xiang-Dong Tang, Xiao-Hong Ma
Format: Article
Language:English
Published: Nature Publishing Group 2025-08-01
Series:Translational Psychiatry
Online Access:https://doi.org/10.1038/s41398-025-03525-x
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