Serum Interleukin-6 in Patients with Burning Mouth Syndrome and Relationship with Depression and Perceived Pain
Objective. To examine alteration of serum interleukin-6 and its clinical significance in burning mouth syndrome (BMS) patients. Methods. 48 BMS patients and 31 healthy controls participated in the study. Serum interleukin-6 was measured by means of ELISA. Hamilton rating scale of depression (HRSD)...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2007-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2007/45327 |
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| _version_ | 1832563198298947584 |
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| author | Qianming Chen Juan Xia Mei Lin Hongmei Zhou Bingqi Li |
| author_facet | Qianming Chen Juan Xia Mei Lin Hongmei Zhou Bingqi Li |
| author_sort | Qianming Chen |
| collection | DOAJ |
| description | Objective. To examine alteration of serum interleukin-6 and its clinical significance in burning mouth syndrome (BMS) patients.
Methods. 48 BMS patients and 31 healthy controls participated in the study. Serum interleukin-6 was measured by means of ELISA. Hamilton rating scale of depression (HRSD) and visual analogue scale (VAS) were used to quantitiate depressive status and pain levels of subjects, respectively.
Results. 15 (31%) patients displayed substantial depressive symptoms (HRSD ≧16). HRSD scores of patients were significantly higher than controls and positively correlated to their VAS values (P=.002). Serum interleukin-6 in patients was much lower than controls and negatively correlated to their VAS values (P=.011). However, no significant relations were found between interleukin-6 and HRSD scores (P=.317).
Conclusions. Serum interleukin-6 in patients with
burning mouth syndrome is decreased and negatively correlated to chronic pain.
Both psychological and neuropathic disorders might act as precipitating factors in
BMS etiopathogenesis. |
| format | Article |
| id | doaj-art-061e45c048d346cf817fe67150ae418d |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2007-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-061e45c048d346cf817fe67150ae418d2025-02-03T01:20:44ZengWileyMediators of Inflammation0962-93511466-18612007-01-01200710.1155/2007/4532745327Serum Interleukin-6 in Patients with Burning Mouth Syndrome and Relationship with Depression and Perceived PainQianming Chen0Juan Xia1Mei Lin2Hongmei Zhou3Bingqi Li4Department of Oral Medicine, West China College of Stomatology, Sichuan University, Chengdu, Sichuan 610041, ChinaDepartment of Oral Medicine, Guanghua School of Stomatology, Sun Yat-Sen University, Guangzhou, Guangdong 510055, ChinaDepartment of Oral Medicine, West China College of Stomatology, Sichuan University, Chengdu, Sichuan 610041, ChinaDepartment of Oral Medicine, West China College of Stomatology, Sichuan University, Chengdu, Sichuan 610041, ChinaDepartment of Oral Medicine, West China College of Stomatology, Sichuan University, Chengdu, Sichuan 610041, ChinaObjective. To examine alteration of serum interleukin-6 and its clinical significance in burning mouth syndrome (BMS) patients. Methods. 48 BMS patients and 31 healthy controls participated in the study. Serum interleukin-6 was measured by means of ELISA. Hamilton rating scale of depression (HRSD) and visual analogue scale (VAS) were used to quantitiate depressive status and pain levels of subjects, respectively. Results. 15 (31%) patients displayed substantial depressive symptoms (HRSD ≧16). HRSD scores of patients were significantly higher than controls and positively correlated to their VAS values (P=.002). Serum interleukin-6 in patients was much lower than controls and negatively correlated to their VAS values (P=.011). However, no significant relations were found between interleukin-6 and HRSD scores (P=.317). Conclusions. Serum interleukin-6 in patients with burning mouth syndrome is decreased and negatively correlated to chronic pain. Both psychological and neuropathic disorders might act as precipitating factors in BMS etiopathogenesis.http://dx.doi.org/10.1155/2007/45327 |
| spellingShingle | Qianming Chen Juan Xia Mei Lin Hongmei Zhou Bingqi Li Serum Interleukin-6 in Patients with Burning Mouth Syndrome and Relationship with Depression and Perceived Pain Mediators of Inflammation |
| title | Serum Interleukin-6 in Patients with Burning Mouth Syndrome and Relationship with Depression and Perceived Pain |
| title_full | Serum Interleukin-6 in Patients with Burning Mouth Syndrome and Relationship with Depression and Perceived Pain |
| title_fullStr | Serum Interleukin-6 in Patients with Burning Mouth Syndrome and Relationship with Depression and Perceived Pain |
| title_full_unstemmed | Serum Interleukin-6 in Patients with Burning Mouth Syndrome and Relationship with Depression and Perceived Pain |
| title_short | Serum Interleukin-6 in Patients with Burning Mouth Syndrome and Relationship with Depression and Perceived Pain |
| title_sort | serum interleukin 6 in patients with burning mouth syndrome and relationship with depression and perceived pain |
| url | http://dx.doi.org/10.1155/2007/45327 |
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