Thrombospondin-1 induces immunogenic cell death in human mucoepidermoid carcinoma MC-3 cells via the PERK/eIF2α signaling pathway: potential implications for tumor immunotherapy

Thrombospondin-1 induces immunogenic cell death in human mucoepidermoid carcinoma MC-3 cells via the PERK/eIF2α signaling pathway: potential implications for tumor immunotherapy

Abstract Objective To investigate whether Thrombospondin-1 (TSP-1) induces immunogenic cell death (ICD) in human mucoepidermoid carcinoma (MC-3) cells and explore its potential to induce calreticulin (CRT) exposure via the PERK/eIF2α signaling pathway. Methods The MC-3 cell line was used as the rese...

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Bibliographic Details
Main Authors: Yixuan Zhu, Kaizhi Cai, Lijuan Guo, Huan Zhang, Li Guan, Zongyao Zhang, Pengcheng Huang, Sen Yang
Format: Article
Language:English
Published: Springer 2025-04-01
Series:Discover Oncology
Subjects:
Thrombospondin-1
MC-3 cell line
Immunogenic death
Calreticulin
PERK/eIF2α signaling pathway
Tumor immunotherapy
Online Access:https://doi.org/10.1007/s12672-025-02315-7
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https://doi.org/10.1007/s12672-025-02315-7

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