Shatavari supplementation during eight weeks of resistance training increases training load, enhances skeletal muscle contractility and alters the skeletal muscle proteome in older women
IntroductionShatavari is a herbal dietary supplement that may increase skeletal muscle strength in younger and older adults. Shatavari contains compounds with both estradiol-like and antioxidant properties, which could enhance muscle function. Postmenopausal women may derive the greatest benefit, as...
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Frontiers Media S.A.
2025-01-01
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| Series: | Frontiers in Nutrition |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnut.2024.1498674/full |
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| author | Elsa Greed Elsa Greed Jack Pritchard Lauren Struszczak Esra Bozbaş Georgia Ek Jordan Acheson Jordan Acheson Ben Winney Aaliyah Qadir Karl Ka-Lam Wong Joanna Bowtell Mary O’Leary |
| author_facet | Elsa Greed Elsa Greed Jack Pritchard Lauren Struszczak Esra Bozbaş Georgia Ek Jordan Acheson Jordan Acheson Ben Winney Aaliyah Qadir Karl Ka-Lam Wong Joanna Bowtell Mary O’Leary |
| author_sort | Elsa Greed |
| collection | DOAJ |
| description | IntroductionShatavari is a herbal dietary supplement that may increase skeletal muscle strength in younger and older adults. Shatavari contains compounds with both estradiol-like and antioxidant properties, which could enhance muscle function. Postmenopausal women may derive the greatest benefit, as estrogen deficiency adversely impacts skeletal muscle function. However, mechanistic insights are limited and the effects of shatavari on muscle function require further characterization.MethodsIn this randomized, double-blind trial, 17 young (23 ± 5 yr) and 22 older (63 ± 5 yr) women completed an 8-week leg resistance training programme. They consumed either a placebo or shatavari (1000 mg/d, equivalent to 26,500 mg/d fresh weight) supplement throughout. Pre and post training, measures of leg strength, neuromuscular function and vastus lateralis (VL) biopsies were obtained. Tandem-mass-tagged VL proteomic analyses were performed. Data were analyzed using a differential expression (Reactome) approach.ResultsShatavari supplementation increased 8-week training load in older women (leg press repetitions completed, p = 0.049, ηp2 = 0.198; maximum weight lifted each week, p = 0.03, ηp2 = 0.386; ANCOVA). There was no effect of shatavari on muscle strength post-training. VL half relaxation time was shortened post-training in older women supplemented with shatavari (post-training change: shatavari −11.74 ± 11.93%, placebo 0.42 ± 14.73%, p = 0.021; ANCOVA). Shatavari supplementation diminished the expression of extracellular matrix proteins in both cohorts. Expression of proteins related to striated muscle contraction, transcription and translation were decreased by shatavari supplementation in older women.DiscussionThese novel observations support the notion that shatavari supplementation confers resistance to neuromuscular fatigue in older women. This could ameliorate sarcopenic declines in skeletal muscle function. |
| format | Article |
| id | doaj-art-06199555d79a4549878a793a048bf051 |
| institution | Kabale University |
| issn | 2296-861X |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Nutrition |
| spelling | doaj-art-06199555d79a4549878a793a048bf0512025-01-06T06:59:10ZengFrontiers Media S.A.Frontiers in Nutrition2296-861X2025-01-011110.3389/fnut.2024.14986741498674Shatavari supplementation during eight weeks of resistance training increases training load, enhances skeletal muscle contractility and alters the skeletal muscle proteome in older womenElsa Greed0Elsa Greed1Jack Pritchard2Lauren Struszczak3Esra Bozbaş4Georgia Ek5Jordan Acheson6Jordan Acheson7Ben Winney8Aaliyah Qadir9Karl Ka-Lam Wong10Joanna Bowtell11Mary O’Leary12Faculty of Health and Life Sciences, Department of Public Health and Sport Sciences, University of Exeter, Exeter, United KingdomSchool of Sport, Exercise and Rehabilitation Sciences, University of Birmingham, Birmingham, United KingdomFaculty of Health and Life Sciences, Department of Public Health and Sport Sciences, University of Exeter, Exeter, United KingdomFaculty of Health and Life Sciences, Department of Public Health and Sport Sciences, University of Exeter, Exeter, United KingdomFaculty of Health and Life Sciences, Department of Public Health and Sport Sciences, University of Exeter, Exeter, United KingdomFaculty of Health and Life Sciences, Department of Public Health and Sport Sciences, University of Exeter, Exeter, United KingdomFaculty of Health and Life Sciences, Department of Public Health and Sport Sciences, University of Exeter, Exeter, United KingdomDepartment of Sport and Exercise Sciences, Institute of Sport, Faculty of Science and Engineering, Manchester Metropolitan University, Manchester, United KingdomFaculty of Health and Life Sciences, Department of Public Health and Sport Sciences, University of Exeter, Exeter, United KingdomFaculty of Health and Life Sciences, Department of Public Health and Sport Sciences, University of Exeter, Exeter, United KingdomFaculty of Health and Life Sciences, Department of Public Health and Sport Sciences, University of Exeter, Exeter, United KingdomFaculty of Health and Life Sciences, Department of Public Health and Sport Sciences, University of Exeter, Exeter, United KingdomFaculty of Health and Life Sciences, Department of Public Health and Sport Sciences, University of Exeter, Exeter, United KingdomIntroductionShatavari is a herbal dietary supplement that may increase skeletal muscle strength in younger and older adults. Shatavari contains compounds with both estradiol-like and antioxidant properties, which could enhance muscle function. Postmenopausal women may derive the greatest benefit, as estrogen deficiency adversely impacts skeletal muscle function. However, mechanistic insights are limited and the effects of shatavari on muscle function require further characterization.MethodsIn this randomized, double-blind trial, 17 young (23 ± 5 yr) and 22 older (63 ± 5 yr) women completed an 8-week leg resistance training programme. They consumed either a placebo or shatavari (1000 mg/d, equivalent to 26,500 mg/d fresh weight) supplement throughout. Pre and post training, measures of leg strength, neuromuscular function and vastus lateralis (VL) biopsies were obtained. Tandem-mass-tagged VL proteomic analyses were performed. Data were analyzed using a differential expression (Reactome) approach.ResultsShatavari supplementation increased 8-week training load in older women (leg press repetitions completed, p = 0.049, ηp2 = 0.198; maximum weight lifted each week, p = 0.03, ηp2 = 0.386; ANCOVA). There was no effect of shatavari on muscle strength post-training. VL half relaxation time was shortened post-training in older women supplemented with shatavari (post-training change: shatavari −11.74 ± 11.93%, placebo 0.42 ± 14.73%, p = 0.021; ANCOVA). Shatavari supplementation diminished the expression of extracellular matrix proteins in both cohorts. Expression of proteins related to striated muscle contraction, transcription and translation were decreased by shatavari supplementation in older women.DiscussionThese novel observations support the notion that shatavari supplementation confers resistance to neuromuscular fatigue in older women. This could ameliorate sarcopenic declines in skeletal muscle function.https://www.frontiersin.org/articles/10.3389/fnut.2024.1498674/fullmuscleskeletalexerciseresistance trainingproteomicsaging |
| spellingShingle | Elsa Greed Elsa Greed Jack Pritchard Lauren Struszczak Esra Bozbaş Georgia Ek Jordan Acheson Jordan Acheson Ben Winney Aaliyah Qadir Karl Ka-Lam Wong Joanna Bowtell Mary O’Leary Shatavari supplementation during eight weeks of resistance training increases training load, enhances skeletal muscle contractility and alters the skeletal muscle proteome in older women Frontiers in Nutrition muscle skeletal exercise resistance training proteomics aging |
| title | Shatavari supplementation during eight weeks of resistance training increases training load, enhances skeletal muscle contractility and alters the skeletal muscle proteome in older women |
| title_full | Shatavari supplementation during eight weeks of resistance training increases training load, enhances skeletal muscle contractility and alters the skeletal muscle proteome in older women |
| title_fullStr | Shatavari supplementation during eight weeks of resistance training increases training load, enhances skeletal muscle contractility and alters the skeletal muscle proteome in older women |
| title_full_unstemmed | Shatavari supplementation during eight weeks of resistance training increases training load, enhances skeletal muscle contractility and alters the skeletal muscle proteome in older women |
| title_short | Shatavari supplementation during eight weeks of resistance training increases training load, enhances skeletal muscle contractility and alters the skeletal muscle proteome in older women |
| title_sort | shatavari supplementation during eight weeks of resistance training increases training load enhances skeletal muscle contractility and alters the skeletal muscle proteome in older women |
| topic | muscle skeletal exercise resistance training proteomics aging |
| url | https://www.frontiersin.org/articles/10.3389/fnut.2024.1498674/full |
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