Marine Jellyfish Collagen and Other Bioactive Natural Compounds from the Sea, with Significant Potential for Wound Healing and Repair Materials
Skin health must be ensured at all times in the case of wounds when the skin is subjected to traumatic actions that require multiple wound-healing measures. Wound healing is a complex, multi-phase biological process critical for restoring skin integrity after trauma. This study investigates the deve...
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| Format: | Article |
| Language: | English |
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MDPI AG
2025-06-01
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| Series: | Marine Drugs |
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| Online Access: | https://www.mdpi.com/1660-3397/23/6/252 |
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| author | Ana-Maria Pesterau Antoanela Popescu Rodica Sirbu Emin Cadar Florica Busuricu Ana-Maria Laura Dragan Carolina Pascale Ana-Maria Ionescu Claudia Florina Bogdan-Andreescu Marius-Daniel Radu Cezar Laurentiu Tomescu |
| author_facet | Ana-Maria Pesterau Antoanela Popescu Rodica Sirbu Emin Cadar Florica Busuricu Ana-Maria Laura Dragan Carolina Pascale Ana-Maria Ionescu Claudia Florina Bogdan-Andreescu Marius-Daniel Radu Cezar Laurentiu Tomescu |
| author_sort | Ana-Maria Pesterau |
| collection | DOAJ |
| description | Skin health must be ensured at all times in the case of wounds when the skin is subjected to traumatic actions that require multiple wound-healing measures. Wound healing is a complex, multi-phase biological process critical for restoring skin integrity after trauma. This study investigates the development and evaluation of a novel composite hydrogel formulated from collagen peptides extracted from the jellyfish <i>Rhizostoma pulmo</i> and hydroethanolic extracts from the brown alga <i>Cystoseira barbata</i>, both sourced from the Romanian Black Sea coast. Throughout the work, the characteristics due to the biochemical compositions of the extracts from the brown alga <i>C. barbata</i> and from the jellyfish <i>R. pulmo</i> are highlighted as important, emphasizing the content of polysaccharides, proteins, and lipids. Total phenol content was analyzed for three extracts from natural products. The biochemical composition, antioxidant, antimicrobial, and in vitro wound-healing properties of the components and their composite (JPC-ALG) were assessed. The rheological behavior and optical microscopy studies of collagen hydrogels were prepared. The general mechanisms of wound healing with the involvement of polysaccharides and collagen peptides existing in all categories of extracts were highlighted. The study of the effects of JPC-ALG composites and individual extracts on fibroblast and keratocyte cell lines is also presented. Results demonstrated that the composite exhibited synergistic effects, enhancing fibroblast and keratinocyte migration and proliferation, key factors in wound closure. The findings support the potential application of this marine-derived bioactive composite as a promising biomaterial for wound-healing therapies. |
| format | Article |
| id | doaj-art-0607c9d7682e42a38e3f7674a49ca161 |
| institution | Kabale University |
| issn | 1660-3397 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Marine Drugs |
| spelling | doaj-art-0607c9d7682e42a38e3f7674a49ca1612025-08-20T03:27:25ZengMDPI AGMarine Drugs1660-33972025-06-0123625210.3390/md23060252Marine Jellyfish Collagen and Other Bioactive Natural Compounds from the Sea, with Significant Potential for Wound Healing and Repair MaterialsAna-Maria Pesterau0Antoanela Popescu1Rodica Sirbu2Emin Cadar3Florica Busuricu4Ana-Maria Laura Dragan5Carolina Pascale6Ana-Maria Ionescu7Claudia Florina Bogdan-Andreescu8Marius-Daniel Radu9Cezar Laurentiu Tomescu10Organizing Institution for Doctoral University Studies of “Carol Davila”, Faculty of Pharmacy, University of Medicine and Pharmacy Bucharest, Dionisie Lupu Street, No. 37, Sector 2, 020021 Bucharest, RomaniaFaculty of Pharmacy, “Ovidius” University of Constanta, Capitan Aviator Al. Serbanescu Street, No. 6, Campus, Corp C, 900470 Constanta, RomaniaOrganizing Institution for Doctoral University Studies of “Carol Davila”, Faculty of Pharmacy, University of Medicine and Pharmacy Bucharest, Dionisie Lupu Street, No. 37, Sector 2, 020021 Bucharest, RomaniaFaculty of Pharmacy, “Ovidius” University of Constanta, Capitan Aviator Al. Serbanescu Street, No. 6, Campus, Corp C, 900470 Constanta, RomaniaFaculty of Pharmacy, “Ovidius” University of Constanta, Capitan Aviator Al. Serbanescu Street, No. 6, Campus, Corp C, 900470 Constanta, RomaniaOrganizing Institution for Doctoral University Studies of “Carol Davila”, Faculty of Pharmacy, University of Medicine and Pharmacy Bucharest, Dionisie Lupu Street, No. 37, Sector 2, 020021 Bucharest, RomaniaOrganizing Institution for Doctoral University Studies of “Carol Davila”, Faculty of Pharmacy, University of Medicine and Pharmacy Bucharest, Dionisie Lupu Street, No. 37, Sector 2, 020021 Bucharest, RomaniaFaculty of Medicine, “Ovidius” University of Constanta, University Alley, No. 1, Campus, Building B, 9000470 Constanta, RomaniaFaculty of Dental Medicine, Department of Speciality Disciplines, “Titu Maiorescu” University, 031593 Bucharest, RomaniaFaculty of Natural and Agriculture Science, “Ovidius” University of Constanta, University Alley, No. 1, Campus, Building B, 9000470 Constanta, RomaniaFaculty of Medicine, “Ovidius” University of Constanta, University Alley, No. 1, Campus, Building B, 9000470 Constanta, RomaniaSkin health must be ensured at all times in the case of wounds when the skin is subjected to traumatic actions that require multiple wound-healing measures. Wound healing is a complex, multi-phase biological process critical for restoring skin integrity after trauma. This study investigates the development and evaluation of a novel composite hydrogel formulated from collagen peptides extracted from the jellyfish <i>Rhizostoma pulmo</i> and hydroethanolic extracts from the brown alga <i>Cystoseira barbata</i>, both sourced from the Romanian Black Sea coast. Throughout the work, the characteristics due to the biochemical compositions of the extracts from the brown alga <i>C. barbata</i> and from the jellyfish <i>R. pulmo</i> are highlighted as important, emphasizing the content of polysaccharides, proteins, and lipids. Total phenol content was analyzed for three extracts from natural products. The biochemical composition, antioxidant, antimicrobial, and in vitro wound-healing properties of the components and their composite (JPC-ALG) were assessed. The rheological behavior and optical microscopy studies of collagen hydrogels were prepared. The general mechanisms of wound healing with the involvement of polysaccharides and collagen peptides existing in all categories of extracts were highlighted. The study of the effects of JPC-ALG composites and individual extracts on fibroblast and keratocyte cell lines is also presented. Results demonstrated that the composite exhibited synergistic effects, enhancing fibroblast and keratinocyte migration and proliferation, key factors in wound closure. The findings support the potential application of this marine-derived bioactive composite as a promising biomaterial for wound-healing therapies.https://www.mdpi.com/1660-3397/23/6/252marine bioactive compoundsmarine metabolitesskin healthwound healing |
| spellingShingle | Ana-Maria Pesterau Antoanela Popescu Rodica Sirbu Emin Cadar Florica Busuricu Ana-Maria Laura Dragan Carolina Pascale Ana-Maria Ionescu Claudia Florina Bogdan-Andreescu Marius-Daniel Radu Cezar Laurentiu Tomescu Marine Jellyfish Collagen and Other Bioactive Natural Compounds from the Sea, with Significant Potential for Wound Healing and Repair Materials Marine Drugs marine bioactive compounds marine metabolites skin health wound healing |
| title | Marine Jellyfish Collagen and Other Bioactive Natural Compounds from the Sea, with Significant Potential for Wound Healing and Repair Materials |
| title_full | Marine Jellyfish Collagen and Other Bioactive Natural Compounds from the Sea, with Significant Potential for Wound Healing and Repair Materials |
| title_fullStr | Marine Jellyfish Collagen and Other Bioactive Natural Compounds from the Sea, with Significant Potential for Wound Healing and Repair Materials |
| title_full_unstemmed | Marine Jellyfish Collagen and Other Bioactive Natural Compounds from the Sea, with Significant Potential for Wound Healing and Repair Materials |
| title_short | Marine Jellyfish Collagen and Other Bioactive Natural Compounds from the Sea, with Significant Potential for Wound Healing and Repair Materials |
| title_sort | marine jellyfish collagen and other bioactive natural compounds from the sea with significant potential for wound healing and repair materials |
| topic | marine bioactive compounds marine metabolites skin health wound healing |
| url | https://www.mdpi.com/1660-3397/23/6/252 |
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