The association between rapid antiretroviral therapy initiation and brain structure and function based on multimodal magnetic resonance imaging in HIV-positive men who have sex with men
Abstract An increasing number of treatment guidelines recommend rapid initiation of antiretroviral therapy (ART) after the diagnosis of human immunodeficiency virus (HIV) infection. However, data on the association between rapid ART initiation and alterations in brain structure and function remain l...
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2025-01-01
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| Online Access: | https://doi.org/10.1186/s12879-024-10397-x |
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| author | Yihui He Yang Zhang Taiyi Jiang Miaotian Cai Guangqiang Sun Yundong Ma Jiahao Ji Bo Yang Bin Yang Junyi Duan Dongxia Wu Lijun Sun Lili Dai Yulin Zhang Hao Wu Wenhao Jiang Tong Zhang Lei Wang |
| author_facet | Yihui He Yang Zhang Taiyi Jiang Miaotian Cai Guangqiang Sun Yundong Ma Jiahao Ji Bo Yang Bin Yang Junyi Duan Dongxia Wu Lijun Sun Lili Dai Yulin Zhang Hao Wu Wenhao Jiang Tong Zhang Lei Wang |
| author_sort | Yihui He |
| collection | DOAJ |
| description | Abstract An increasing number of treatment guidelines recommend rapid initiation of antiretroviral therapy (ART) after the diagnosis of human immunodeficiency virus (HIV) infection. However, data on the association between rapid ART initiation and alterations in brain structure and function remain limited in people with HIV (PWH). A cross-sectional analysis was conducted on HIV-positive men who have sex with men (MSM) undergoing ART. Fifty-four participants who started ART within 30 days of confirmed HIV diagnosis (rapid ART group) and 20 participants who started ART more than 6 months of confirmed HIV diagnosis (non-rapid ART group) completed clinical assessments and multimodal magnetic resonance imaging scans to obtain both anatomical and resting-state functional images. Compared to PWH in the non-rapid ART group, those in the rapid ART group exhibited a greater total gray matter volume (P = 0.001) and functional changes, including a lower amplitude of low-frequency fluctuations in the left angular gyrus (P < 0.001). Moreover, the results of the main effects and interactions indicated that rapid ART initiation had main effects on major imaging outcomes. The validation analysis results in participants who started ART within 7 days of confirmed HIV diagnosis generally corroborated and complemented the aforementioned findings. Our study demonstrated brain gray matter volume atrophy and functional alterations in PWH of the non-rapid ART group compared to those in the rapid ART group, suggesting that rapid ART initiation may be associated with better brain structure and function changes in HIV-positive MSM. |
| format | Article |
| id | doaj-art-060772ab5d744a5fbc70844aabb6fba8 |
| institution | Kabale University |
| issn | 1471-2334 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Infectious Diseases |
| spelling | doaj-art-060772ab5d744a5fbc70844aabb6fba82025-01-12T12:09:41ZengBMCBMC Infectious Diseases1471-23342025-01-0125111210.1186/s12879-024-10397-xThe association between rapid antiretroviral therapy initiation and brain structure and function based on multimodal magnetic resonance imaging in HIV-positive men who have sex with menYihui He0Yang Zhang1Taiyi Jiang2Miaotian Cai3Guangqiang Sun4Yundong Ma5Jiahao Ji6Bo Yang7Bin Yang8Junyi Duan9Dongxia Wu10Lijun Sun11Lili Dai12Yulin Zhang13Hao Wu14Wenhao Jiang15Tong Zhang16Lei Wang17Postgraduate Union Training Base of Jinzhou Medical University, PLA Rocket Force Characteristic Medical CenterCenter for Infectious Disease, Beijing Youan Hospital, Capital Medical UniversityCenter for Infectious Disease, Beijing Youan Hospital, Capital Medical UniversityDepartment of Respiratory and Critical Care Medicine, Beijing Youan Hospital, Capital Medical UniversityBeijing Key Laboratory of Mental Disorders, National Clinical Research Center for Mental Disorders and National Center for Mental Disorders, Beijing Anding Hospital, Capital Medical UniversityBeijing Key Laboratory of Mental Disorders, National Clinical Research Center for Mental Disorders and National Center for Mental Disorders, Beijing Anding Hospital, Capital Medical UniversityCenter for Infectious Disease, Beijing Youan Hospital, Capital Medical UniversityThe Second Hospital of BeijingThe Second Hospital of BeijingCenter for Infectious Disease, Beijing Youan Hospital, Capital Medical UniversityCenter for Infectious Disease, Beijing Youan Hospital, Capital Medical UniversityCenter for Infectious Disease, Beijing Youan Hospital, Capital Medical UniversityCenter for Infectious Disease, Beijing Youan Hospital, Capital Medical UniversityDepartment of Respiratory and Critical Care Medicine, Beijing Youan Hospital, Capital Medical UniversityCenter for Infectious Disease, Beijing Youan Hospital, Capital Medical UniversityThe Second Hospital of BeijingCenter for Infectious Disease, Beijing Youan Hospital, Capital Medical UniversityPostgraduate Union Training Base of Jinzhou Medical University, PLA Rocket Force Characteristic Medical CenterAbstract An increasing number of treatment guidelines recommend rapid initiation of antiretroviral therapy (ART) after the diagnosis of human immunodeficiency virus (HIV) infection. However, data on the association between rapid ART initiation and alterations in brain structure and function remain limited in people with HIV (PWH). A cross-sectional analysis was conducted on HIV-positive men who have sex with men (MSM) undergoing ART. Fifty-four participants who started ART within 30 days of confirmed HIV diagnosis (rapid ART group) and 20 participants who started ART more than 6 months of confirmed HIV diagnosis (non-rapid ART group) completed clinical assessments and multimodal magnetic resonance imaging scans to obtain both anatomical and resting-state functional images. Compared to PWH in the non-rapid ART group, those in the rapid ART group exhibited a greater total gray matter volume (P = 0.001) and functional changes, including a lower amplitude of low-frequency fluctuations in the left angular gyrus (P < 0.001). Moreover, the results of the main effects and interactions indicated that rapid ART initiation had main effects on major imaging outcomes. The validation analysis results in participants who started ART within 7 days of confirmed HIV diagnosis generally corroborated and complemented the aforementioned findings. Our study demonstrated brain gray matter volume atrophy and functional alterations in PWH of the non-rapid ART group compared to those in the rapid ART group, suggesting that rapid ART initiation may be associated with better brain structure and function changes in HIV-positive MSM.https://doi.org/10.1186/s12879-024-10397-xHuman immunodeficiency virusAntiretroviral therapyRapid initiationMultimodal magnetic resonance imagingNeuropsychiatric disorder |
| spellingShingle | Yihui He Yang Zhang Taiyi Jiang Miaotian Cai Guangqiang Sun Yundong Ma Jiahao Ji Bo Yang Bin Yang Junyi Duan Dongxia Wu Lijun Sun Lili Dai Yulin Zhang Hao Wu Wenhao Jiang Tong Zhang Lei Wang The association between rapid antiretroviral therapy initiation and brain structure and function based on multimodal magnetic resonance imaging in HIV-positive men who have sex with men BMC Infectious Diseases Human immunodeficiency virus Antiretroviral therapy Rapid initiation Multimodal magnetic resonance imaging Neuropsychiatric disorder |
| title | The association between rapid antiretroviral therapy initiation and brain structure and function based on multimodal magnetic resonance imaging in HIV-positive men who have sex with men |
| title_full | The association between rapid antiretroviral therapy initiation and brain structure and function based on multimodal magnetic resonance imaging in HIV-positive men who have sex with men |
| title_fullStr | The association between rapid antiretroviral therapy initiation and brain structure and function based on multimodal magnetic resonance imaging in HIV-positive men who have sex with men |
| title_full_unstemmed | The association between rapid antiretroviral therapy initiation and brain structure and function based on multimodal magnetic resonance imaging in HIV-positive men who have sex with men |
| title_short | The association between rapid antiretroviral therapy initiation and brain structure and function based on multimodal magnetic resonance imaging in HIV-positive men who have sex with men |
| title_sort | association between rapid antiretroviral therapy initiation and brain structure and function based on multimodal magnetic resonance imaging in hiv positive men who have sex with men |
| topic | Human immunodeficiency virus Antiretroviral therapy Rapid initiation Multimodal magnetic resonance imaging Neuropsychiatric disorder |
| url | https://doi.org/10.1186/s12879-024-10397-x |
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