In C. elegans, high levels of dsRNA allow RNAi in the absence of RDE-4.

In C. elegans, high levels of dsRNA allow RNAi in the absence of RDE-4.

C. elegans Dicer requires an accessory double-stranded RNA binding protein, RDE-4, to enact the first step of RNA interference, the cleavage of dsRNA to produce siRNA. While RDE-4 is typically essential for RNAi, we report that in the presence of high concentrations of trigger dsRNA, rde-4 deficient...

Full description

Saved in:
Bibliographic Details
Main Authors: Jeffrey W Habig, P Joseph Aruscavage, Brenda L Bass
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2008-01-01
Series:PLoS ONE
Online Access:https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0004052&type=printable
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items

Similar Items