Understanding therapeutic tolerance through a mathematical model of drug-induced resistance

Abstract There is growing recognition that phenotypic plasticity enables cancer cells to adapt to various environmental conditions. An example of this adaptability is the ability of an initially sensitive population of cancer cells to acquire resistance and persist in the presence of therapeutic age...

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Bibliographic Details
Main Authors: Jana L. Gevertz, James M. Greene, Samantha Prosperi, Natacha Comandante-Lou, Eduardo D. Sontag
Format: Article
Language:English
Published: Nature Portfolio 2025-04-01
Series:npj Systems Biology and Applications
Online Access:https://doi.org/10.1038/s41540-025-00511-3
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