TET-mediated 5hmC in breast cancer: mechanism and clinical potential
Breast cancer is the most common cancer among women, with differences in clinical features due to its distinct molecular subtypes. Current studies have demonstrated that epigenetic modifications play a crucial role in regulating the progression of breast cancer. Among these mechanisms, DNA demethyla...
Saved in:
| Main Authors: | , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Taylor & Francis Group
2025-12-01
|
| Series: | Epigenetics |
| Subjects: | |
| Online Access: | https://www.tandfonline.com/doi/10.1080/15592294.2025.2473250 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850109333483814912 |
|---|---|
| author | Jiahang Zhang Nadire Aishan Zhongqiu Zheng Siwei Ju Qina He Qingna Meng Xixi Lin Jiaheng Lang Jichun Zhou Yongxia Chen Bojian Xie Yangjun Cai Feiyang Ji Linbo Wang |
| author_facet | Jiahang Zhang Nadire Aishan Zhongqiu Zheng Siwei Ju Qina He Qingna Meng Xixi Lin Jiaheng Lang Jichun Zhou Yongxia Chen Bojian Xie Yangjun Cai Feiyang Ji Linbo Wang |
| author_sort | Jiahang Zhang |
| collection | DOAJ |
| description | Breast cancer is the most common cancer among women, with differences in clinical features due to its distinct molecular subtypes. Current studies have demonstrated that epigenetic modifications play a crucial role in regulating the progression of breast cancer. Among these mechanisms, DNA demethylation and its reverse process have been studied extensively for their roles in activating or silencing cancer related gene expression. Specifically, Ten-Eleven Translocation (TET) enzymes are involved in the conversion process from 5-methylcytosine (5mC) to 5-hydroxymethylcytosine (5hmC), which results in a significant difference in the global level of 5hmC in breast cancer compared with normal tissues. In this review, we summarize the functions of TET proteins and the regulated 5hmC levels in the pathogenesis of breast cancer. Discussions on the clinical values of 5hmC in early diagnosis and the prediction of prognosis are also mentioned. |
| format | Article |
| id | doaj-art-06060717e348403c87d2b9ebf9bfc51e |
| institution | OA Journals |
| issn | 1559-2294 1559-2308 |
| language | English |
| publishDate | 2025-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Epigenetics |
| spelling | doaj-art-06060717e348403c87d2b9ebf9bfc51e2025-08-20T02:38:06ZengTaylor & Francis GroupEpigenetics1559-22941559-23082025-12-0120110.1080/15592294.2025.2473250TET-mediated 5hmC in breast cancer: mechanism and clinical potentialJiahang Zhang0Nadire Aishan1Zhongqiu Zheng2Siwei Ju3Qina He4Qingna Meng5Xixi Lin6Jiaheng Lang7Jichun Zhou8Yongxia Chen9Bojian Xie10Yangjun Cai11Feiyang Ji12Linbo Wang13Department of Surgical Oncology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, ChinaDepartment of Surgical Oncology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, ChinaDepartment of Breast and Thyroid Surgery, Taizhou Hospital of Zhejiang Province, Taizhou, Zhejiang, ChinaDepartment of Surgical Oncology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, ChinaDepartment of Surgical Oncology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, ChinaDepartment of Surgical Oncology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, ChinaDepartment of Surgical Oncology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, ChinaDepartment of Surgical Oncology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, ChinaDepartment of Surgical Oncology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, ChinaDepartment of Surgical Oncology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, ChinaDepartment of Breast and Thyroid Surgery, Taizhou Hospital of Zhejiang Province, Taizhou, Zhejiang, ChinaDepartment of Breast and Thyroid Surgery, Taizhou Hospital of Zhejiang Province, Taizhou, Zhejiang, ChinaDepartment of Surgical Oncology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, ChinaDepartment of Surgical Oncology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, ChinaBreast cancer is the most common cancer among women, with differences in clinical features due to its distinct molecular subtypes. Current studies have demonstrated that epigenetic modifications play a crucial role in regulating the progression of breast cancer. Among these mechanisms, DNA demethylation and its reverse process have been studied extensively for their roles in activating or silencing cancer related gene expression. Specifically, Ten-Eleven Translocation (TET) enzymes are involved in the conversion process from 5-methylcytosine (5mC) to 5-hydroxymethylcytosine (5hmC), which results in a significant difference in the global level of 5hmC in breast cancer compared with normal tissues. In this review, we summarize the functions of TET proteins and the regulated 5hmC levels in the pathogenesis of breast cancer. Discussions on the clinical values of 5hmC in early diagnosis and the prediction of prognosis are also mentioned.https://www.tandfonline.com/doi/10.1080/15592294.2025.2473250Breast cancer5hmCTET protein |
| spellingShingle | Jiahang Zhang Nadire Aishan Zhongqiu Zheng Siwei Ju Qina He Qingna Meng Xixi Lin Jiaheng Lang Jichun Zhou Yongxia Chen Bojian Xie Yangjun Cai Feiyang Ji Linbo Wang TET-mediated 5hmC in breast cancer: mechanism and clinical potential Epigenetics Breast cancer 5hmC TET protein |
| title | TET-mediated 5hmC in breast cancer: mechanism and clinical potential |
| title_full | TET-mediated 5hmC in breast cancer: mechanism and clinical potential |
| title_fullStr | TET-mediated 5hmC in breast cancer: mechanism and clinical potential |
| title_full_unstemmed | TET-mediated 5hmC in breast cancer: mechanism and clinical potential |
| title_short | TET-mediated 5hmC in breast cancer: mechanism and clinical potential |
| title_sort | tet mediated 5hmc in breast cancer mechanism and clinical potential |
| topic | Breast cancer 5hmC TET protein |
| url | https://www.tandfonline.com/doi/10.1080/15592294.2025.2473250 |
| work_keys_str_mv | AT jiahangzhang tetmediated5hmcinbreastcancermechanismandclinicalpotential AT nadireaishan tetmediated5hmcinbreastcancermechanismandclinicalpotential AT zhongqiuzheng tetmediated5hmcinbreastcancermechanismandclinicalpotential AT siweiju tetmediated5hmcinbreastcancermechanismandclinicalpotential AT qinahe tetmediated5hmcinbreastcancermechanismandclinicalpotential AT qingnameng tetmediated5hmcinbreastcancermechanismandclinicalpotential AT xixilin tetmediated5hmcinbreastcancermechanismandclinicalpotential AT jiahenglang tetmediated5hmcinbreastcancermechanismandclinicalpotential AT jichunzhou tetmediated5hmcinbreastcancermechanismandclinicalpotential AT yongxiachen tetmediated5hmcinbreastcancermechanismandclinicalpotential AT bojianxie tetmediated5hmcinbreastcancermechanismandclinicalpotential AT yangjuncai tetmediated5hmcinbreastcancermechanismandclinicalpotential AT feiyangji tetmediated5hmcinbreastcancermechanismandclinicalpotential AT linbowang tetmediated5hmcinbreastcancermechanismandclinicalpotential |