The Microbiome and Epigenetic Regulation in Bone Metabolism: Implications for Osteoporosis
Introduction: Osteoporosis is a common metabolic disorder associated with aging, characterized by a progressive loss of bone mass and microarchitectural deterioration, leading to an increased risk of fractures and diminished quality of life. Emerging evidence has identified the gut microbiota as a...
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| Format: | Article |
| Language: | English |
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Kazimierz Wielki University
2025-06-01
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| Series: | Journal of Education, Health and Sport |
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| Online Access: | https://apcz.umk.pl/JEHS/article/view/60458 |
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| author | Kornel Celoch Celoch Andrzej Porczyński Jakub Cegielski Kamil Kruk Jakub Bulanda Elżbieta Bukowczan Jakub Ślęzak Daniel Wojciech Martyna Jabrzyk |
| author_facet | Kornel Celoch Celoch Andrzej Porczyński Jakub Cegielski Kamil Kruk Jakub Bulanda Elżbieta Bukowczan Jakub Ślęzak Daniel Wojciech Martyna Jabrzyk |
| author_sort | Kornel Celoch Celoch |
| collection | DOAJ |
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Introduction:
Osteoporosis is a common metabolic disorder associated with aging, characterized by a progressive loss of bone mass and microarchitectural deterioration, leading to an increased risk of fractures and diminished quality of life. Emerging evidence has identified the gut microbiota as a novel regulator of bone homeostasis, implicating intestinal microbial populations in the etiology of osteoporosis and bone metabolism. Understanding the pathways through which the gut microbiome influences skeletal integrity is crucial for advancing targeted strategies in the prevention and management of osteoporosis.
Aim of Study:
This study aims to summarize current knowledge regarding the role of the gut microbiome in the regulation of bone metabolism and its impact on the development and progression of osteoporosis. The review explores the mechanisms through which microbiota influence skeletal homeostasis, evaluates their contribution to osteoporosis susceptibility, and examines the consequences of microbiome changes on bone integrity.
Materials and Methods:
A literature search across PubMed using keywords: “osteoporosis,” “bone metabolism,” “gut microbiome,” “microRNAs,” “epigenetics,” and “bone remodeling.”
Conclusion:
Osteoporosis is increasingly understood as a condition influenced not only by hormonal and nutritional factors but also by the gut microbiota and epigenetic regulators such as microRNAs. These components modulate bone remodeling by affecting osteoblast and osteoclast activity through metabolic and immune pathways. The gut-bone axis and microbiota-miRNA interactions represent a dynamic regulatory network contributing to bone health. Dysbiosis and miRNA dysregulation may disrupt this balance, increasing susceptibility to osteoporosis. Recognizing these mechanisms broadens the understanding of osteoporosis and highlights new opportunities for biomarker discovery and microbiome- or miRNA-targeted therapies.
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| format | Article |
| id | doaj-art-0602d91f80984e8ca75e53db0457672d |
| institution | OA Journals |
| issn | 2391-8306 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Kazimierz Wielki University |
| record_format | Article |
| series | Journal of Education, Health and Sport |
| spelling | doaj-art-0602d91f80984e8ca75e53db0457672d2025-08-20T02:36:30ZengKazimierz Wielki UniversityJournal of Education, Health and Sport2391-83062025-06-018210.12775/JEHS.2025.82.60458The Microbiome and Epigenetic Regulation in Bone Metabolism: Implications for OsteoporosisKornel Celoch Celoch0https://orcid.org/0009-0000-5712-2154Andrzej Porczyński1https://orcid.org/0009-0001-0097-3078Jakub Cegielski2https://orcid.org/0009-0009-4222-0996Kamil Kruk3https://orcid.org/0009-0009-3172-4689Jakub Bulanda4https://orcid.org/0009-0002-2983-4941Elżbieta Bukowczan5https://orcid.org/0009-0001-0986-4433Jakub Ślęzak6https://orcid.org/0009-0000-5719-9063Daniel Wojciech7https://orcid.org/0009-0001-4919-1915Martyna Jabrzyk8https://orcid.org/0009-0007-7961-4986Medical University of Silesia, Poniatowskiego 15, 40-055 Katowice, PolandPlatany Medical Center, Ryżowa 44, 02-495 Warsaw, PolandMedical University of Silesia, Poniatowskiego 15, 40-055 Katowice, PolandMedical University of Silesia, Poniatowskiego 15, 40-055 Katowice, PolandMedical University of Silesia, Poniatowskiego 15, 40-055 Katowice, PolandMedical University of Silesia, Poniatowskiego 15, 40-055 Katowice, PolandMedical University of Silesia, Poniatowskiego 15, 40-055 Katowice, PolandMedical University of Silesia, Poniatowskiego 15, 40-055 Katowice, PolandUniversity of Zielona Góra, Licealna 9, 65-417 Zielona Góra, Poland Introduction: Osteoporosis is a common metabolic disorder associated with aging, characterized by a progressive loss of bone mass and microarchitectural deterioration, leading to an increased risk of fractures and diminished quality of life. Emerging evidence has identified the gut microbiota as a novel regulator of bone homeostasis, implicating intestinal microbial populations in the etiology of osteoporosis and bone metabolism. Understanding the pathways through which the gut microbiome influences skeletal integrity is crucial for advancing targeted strategies in the prevention and management of osteoporosis. Aim of Study: This study aims to summarize current knowledge regarding the role of the gut microbiome in the regulation of bone metabolism and its impact on the development and progression of osteoporosis. The review explores the mechanisms through which microbiota influence skeletal homeostasis, evaluates their contribution to osteoporosis susceptibility, and examines the consequences of microbiome changes on bone integrity. Materials and Methods: A literature search across PubMed using keywords: “osteoporosis,” “bone metabolism,” “gut microbiome,” “microRNAs,” “epigenetics,” and “bone remodeling.” Conclusion: Osteoporosis is increasingly understood as a condition influenced not only by hormonal and nutritional factors but also by the gut microbiota and epigenetic regulators such as microRNAs. These components modulate bone remodeling by affecting osteoblast and osteoclast activity through metabolic and immune pathways. The gut-bone axis and microbiota-miRNA interactions represent a dynamic regulatory network contributing to bone health. Dysbiosis and miRNA dysregulation may disrupt this balance, increasing susceptibility to osteoporosis. Recognizing these mechanisms broadens the understanding of osteoporosis and highlights new opportunities for biomarker discovery and microbiome- or miRNA-targeted therapies. https://apcz.umk.pl/JEHS/article/view/60458osteoporosisbone metabolismgut microbiomemicroRNAsepigeneticsbone remodeling |
| spellingShingle | Kornel Celoch Celoch Andrzej Porczyński Jakub Cegielski Kamil Kruk Jakub Bulanda Elżbieta Bukowczan Jakub Ślęzak Daniel Wojciech Martyna Jabrzyk The Microbiome and Epigenetic Regulation in Bone Metabolism: Implications for Osteoporosis Journal of Education, Health and Sport osteoporosis bone metabolism gut microbiome microRNAs epigenetics bone remodeling |
| title | The Microbiome and Epigenetic Regulation in Bone Metabolism: Implications for Osteoporosis |
| title_full | The Microbiome and Epigenetic Regulation in Bone Metabolism: Implications for Osteoporosis |
| title_fullStr | The Microbiome and Epigenetic Regulation in Bone Metabolism: Implications for Osteoporosis |
| title_full_unstemmed | The Microbiome and Epigenetic Regulation in Bone Metabolism: Implications for Osteoporosis |
| title_short | The Microbiome and Epigenetic Regulation in Bone Metabolism: Implications for Osteoporosis |
| title_sort | microbiome and epigenetic regulation in bone metabolism implications for osteoporosis |
| topic | osteoporosis bone metabolism gut microbiome microRNAs epigenetics bone remodeling |
| url | https://apcz.umk.pl/JEHS/article/view/60458 |
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