Severe generalized edema in a premature neonate: A case report and literature review
Key Clinical Message With no family history, and an atypical phenotype, the clinical diagnosing of Noonan syndrome (NS) can be very difficult. The present case emphasized that generalized edema in neonates may be the potential first symptom of NS. Abstract Severe generalized edema is a rare patholog...
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| Format: | Article |
| Language: | English |
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Wiley
2024-09-01
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| Series: | Clinical Case Reports |
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| Online Access: | https://doi.org/10.1002/ccr3.9341 |
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| author | Haifeng Zong Yingsui Huang Ying Xiong Wentao Gong Bingchun Lin Chuanzhong Yang |
| author_facet | Haifeng Zong Yingsui Huang Ying Xiong Wentao Gong Bingchun Lin Chuanzhong Yang |
| author_sort | Haifeng Zong |
| collection | DOAJ |
| description | Key Clinical Message With no family history, and an atypical phenotype, the clinical diagnosing of Noonan syndrome (NS) can be very difficult. The present case emphasized that generalized edema in neonates may be the potential first symptom of NS. Abstract Severe generalized edema is a rare pathological condition with high mortality in newborns, in particular the premature infants. It is characterized by the extensive subcutaneous tissue edema and the accumulation of fluid in neonatal body fluid compartments. The etiology and pathogenesis of hydrops in neonates are quite complex. Generally speaking, hydrops can be divided into immune hydrops and non‐immune hydrops according to the etiology. It is still challenging in treating severe neonatal edema. In this study, we presented a preterm newborn with severe generalized edema after birth, which was finally diagnosed with Noonan syndrome (NS). The infant clinically manifested as severe generalized edema alone, without the involvement of multiple organ malformation. Generalized edema in neonates was probably the first symptom of NS. Therefore, differential diagnosis of NS is necessary for infants developing generalized edema. |
| format | Article |
| id | doaj-art-05f89c136d7049caa60a3cf07b9882e8 |
| institution | OA Journals |
| issn | 2050-0904 |
| language | English |
| publishDate | 2024-09-01 |
| publisher | Wiley |
| record_format | Article |
| series | Clinical Case Reports |
| spelling | doaj-art-05f89c136d7049caa60a3cf07b9882e82025-08-20T01:59:05ZengWileyClinical Case Reports2050-09042024-09-01129n/an/a10.1002/ccr3.9341Severe generalized edema in a premature neonate: A case report and literature reviewHaifeng Zong0Yingsui Huang1Ying Xiong2Wentao Gong3Bingchun Lin4Chuanzhong Yang5Neonatal Intensive Care Unit Shenzhen Maternity and Child Healthcare Hospital Shenzhen ChinaNeonatal Intensive Care Unit Shenzhen Maternity and Child Healthcare Hospital Shenzhen ChinaNeonatal Intensive Care Unit Shenzhen Maternity and Child Healthcare Hospital Shenzhen ChinaNeonatal Intensive Care Unit Shenzhen Maternity and Child Healthcare Hospital Shenzhen ChinaNeonatal Intensive Care Unit Shenzhen Maternity and Child Healthcare Hospital Shenzhen ChinaNeonatal Intensive Care Unit Shenzhen Maternity and Child Healthcare Hospital Shenzhen ChinaKey Clinical Message With no family history, and an atypical phenotype, the clinical diagnosing of Noonan syndrome (NS) can be very difficult. The present case emphasized that generalized edema in neonates may be the potential first symptom of NS. Abstract Severe generalized edema is a rare pathological condition with high mortality in newborns, in particular the premature infants. It is characterized by the extensive subcutaneous tissue edema and the accumulation of fluid in neonatal body fluid compartments. The etiology and pathogenesis of hydrops in neonates are quite complex. Generally speaking, hydrops can be divided into immune hydrops and non‐immune hydrops according to the etiology. It is still challenging in treating severe neonatal edema. In this study, we presented a preterm newborn with severe generalized edema after birth, which was finally diagnosed with Noonan syndrome (NS). The infant clinically manifested as severe generalized edema alone, without the involvement of multiple organ malformation. Generalized edema in neonates was probably the first symptom of NS. Therefore, differential diagnosis of NS is necessary for infants developing generalized edema.https://doi.org/10.1002/ccr3.9341edemahydropsMAPKnewbornNoonan syndromePTPN11 |
| spellingShingle | Haifeng Zong Yingsui Huang Ying Xiong Wentao Gong Bingchun Lin Chuanzhong Yang Severe generalized edema in a premature neonate: A case report and literature review Clinical Case Reports edema hydrops MAPK newborn Noonan syndrome PTPN11 |
| title | Severe generalized edema in a premature neonate: A case report and literature review |
| title_full | Severe generalized edema in a premature neonate: A case report and literature review |
| title_fullStr | Severe generalized edema in a premature neonate: A case report and literature review |
| title_full_unstemmed | Severe generalized edema in a premature neonate: A case report and literature review |
| title_short | Severe generalized edema in a premature neonate: A case report and literature review |
| title_sort | severe generalized edema in a premature neonate a case report and literature review |
| topic | edema hydrops MAPK newborn Noonan syndrome PTPN11 |
| url | https://doi.org/10.1002/ccr3.9341 |
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