Antimicrobial Susceptibility of Achromobacter Species Isolated from Patients with Urinary Tract Infections
AIM: We aim to investigate the antimicrobial susceptibility, and the clinical and genetic characteristics of urinary tract infections (UTIs) caused by Achromobacter species. BACKGROUND: UTIs due to Achromobacter species are uncommon. Until now, there has been limited data available. METHODS: We retr...
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| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2024-12-01
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| Series: | Journal of Global Antimicrobial Resistance |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213716524003230 |
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| Summary: | AIM: We aim to investigate the antimicrobial susceptibility, and the clinical and genetic characteristics of urinary tract infections (UTIs) caused by Achromobacter species. BACKGROUND: UTIs due to Achromobacter species are uncommon. Until now, there has been limited data available. METHODS: We retrospectively analyzed forty-seven Achromobacter isolates from eighteen patients in a tertiary hospital in Taiwan from 2022 to 2023. RESULTS: Fifteen patients (83%) were male, and the median [IQR] age was 69 [64-80] years. Solid or hematological malignancies were the most frequent underlying diseases (seven cases, 39%). Fourteen patients (78%) had urological abnormalities. Almost all isolates were susceptible to piperacillin-tazobactam (98%) and ceftazidime (96%). 85% were susceptible to imipenem, and 72% were susceptible to trimethoprim-sulfamethoxazole. Low frequencies of susceptibility to cefepime (10%), ciprofloxacin (6%), amikacin (4%), gentamicin (2%), and ceftriaxone (0) were observed. blaOXA-114, a constitutive chromosomal β-lactamase, was also detected in most of the Achromobacter isolates through whole genome sequencing. Four patients (22%) had co-infection with other bacteria in the urinary tract. Eleven patients (61%) received appropriate antibiotics at diagnosis. The general clinical outcome was favorable, and only one patient died within thirty days of diagnosis due to receiving palliative care for terminal malignancy. However, recurrence occurred in eight patients (44%) with urological abnormalities. CONCLUSIONS: UTIs caused by Achromobacter species were primarily seen in elderly individuals with underlying conditions, notably urological abnormalities and malignancies. Managing these infections can be challenging due to high antibiotic resistance and recurrence rates. Piperacillin-tazobactam may be prioritized for treatment. |
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| ISSN: | 2213-7165 |