The types of left ventricular remodeling in patients with rheumatoid arthritis
Studying the factors leading to a pathological change in the cardiac structure in patients with rheumatoid arthritis (RA) can contribute to improvement in early diagnosis and to prevention of premature mortality from cardiovascular events.Objective. To study the types of left ventricular (LV) remode...
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2020-05-01
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| author | I. A. Krivotulova K. V. Korochina T. V. Chernysheva G. E. Kuznetsov L. R. Tenchurina |
| author_facet | I. A. Krivotulova K. V. Korochina T. V. Chernysheva G. E. Kuznetsov L. R. Tenchurina |
| author_sort | I. A. Krivotulova |
| collection | DOAJ |
| description | Studying the factors leading to a pathological change in the cardiac structure in patients with rheumatoid arthritis (RA) can contribute to improvement in early diagnosis and to prevention of premature mortality from cardiovascular events.Objective. To study the types of left ventricular (LV) remodeling in patients with RA, by taking into account traditional cardiovascular risk factors, and to assess the clinical and immunological features of RA and the impact of drug therapy.Patients and methods. The investigation enrolled 74 RA patients who underwent assessment of echocardiography findings, by determining the type of LV remodeling, traditional cardiovascular risk factors, clinical and immunological features of the disease, as well as the current drug therapy.Results and discussion. Eccentric LV hypertrophy (ELVH) (n=33 (44.59%)) and concentric LV hypertrophy (CLVH) (n=34 (45.95%)) occurred at almost the same frequency among the pathological types of LV remodeling in patients with RA. Higher DAS28 values (p<0.0001) were noted in ELVH than in CLVH. There were also positive correlations of EHLH with ESR and CRP level (r= 0.51, p<0.0001; r=0.48, p=0.0001, respectively). The higher values of systolic blood pressure (p=0.0002), body mass index (p=0.01), patient age (p=0.0001), and the incidence of dyslipidemia (p= 0.008) were established in CVLH than in ELVH. LV diastolic dysfunction (DD) was detected much more frequently in RA patients with CLVH than in those with ELVH (p=0.01). The DD parameters (peak A, E/A) correlated with the degree (r=0.5, p<0.0001; r=-0.5. p<0.0001) and stage of hypertension (r=0.54, p<0.0001; r=-0.48, p=0.0001, respectively), as well as with peak A and traditional risk factors, such as patient age (r=0.52, p<0.0001), and high-density lipoprotein cholesterol levels (r=-0.48, p=0.0001).Conclusion. Most patients with RA had signs of LV hypertrophy; moreover, ELVH was closely linked with disease activity, whereas CLVH was related to the traditional risk factors. |
| format | Article |
| id | doaj-art-05f3dcbc5ed6490bb1e5ccbd1cb2cc99 |
| institution | DOAJ |
| issn | 1996-7012 2310-158X |
| language | Russian |
| publishDate | 2020-05-01 |
| publisher | IMA-PRESS LLC |
| record_format | Article |
| series | Современная ревматология |
| spelling | doaj-art-05f3dcbc5ed6490bb1e5ccbd1cb2cc992025-08-20T03:20:58ZrusIMA-PRESS LLCСовременная ревматология1996-70122310-158X2020-05-01142626810.14412/1996-7012-2020-2-62-682260The types of left ventricular remodeling in patients with rheumatoid arthritisI. A. Krivotulova0K. V. Korochina1T. V. Chernysheva2G. E. Kuznetsov3L. R. Tenchurina4Orenburg State Medical University, Ministry of Health of RussiaOrenburg State Medical University, Ministry of Health of RussiaOrenburg State Medical University, Ministry of Health of RussiaOrenburg State Medical University, Ministry of Health of RussiaOrenburg State Medical University, Ministry of Health of RussiaStudying the factors leading to a pathological change in the cardiac structure in patients with rheumatoid arthritis (RA) can contribute to improvement in early diagnosis and to prevention of premature mortality from cardiovascular events.Objective. To study the types of left ventricular (LV) remodeling in patients with RA, by taking into account traditional cardiovascular risk factors, and to assess the clinical and immunological features of RA and the impact of drug therapy.Patients and methods. The investigation enrolled 74 RA patients who underwent assessment of echocardiography findings, by determining the type of LV remodeling, traditional cardiovascular risk factors, clinical and immunological features of the disease, as well as the current drug therapy.Results and discussion. Eccentric LV hypertrophy (ELVH) (n=33 (44.59%)) and concentric LV hypertrophy (CLVH) (n=34 (45.95%)) occurred at almost the same frequency among the pathological types of LV remodeling in patients with RA. Higher DAS28 values (p<0.0001) were noted in ELVH than in CLVH. There were also positive correlations of EHLH with ESR and CRP level (r= 0.51, p<0.0001; r=0.48, p=0.0001, respectively). The higher values of systolic blood pressure (p=0.0002), body mass index (p=0.01), patient age (p=0.0001), and the incidence of dyslipidemia (p= 0.008) were established in CVLH than in ELVH. LV diastolic dysfunction (DD) was detected much more frequently in RA patients with CLVH than in those with ELVH (p=0.01). The DD parameters (peak A, E/A) correlated with the degree (r=0.5, p<0.0001; r=-0.5. p<0.0001) and stage of hypertension (r=0.54, p<0.0001; r=-0.48, p=0.0001, respectively), as well as with peak A and traditional risk factors, such as patient age (r=0.52, p<0.0001), and high-density lipoprotein cholesterol levels (r=-0.48, p=0.0001).Conclusion. Most patients with RA had signs of LV hypertrophy; moreover, ELVH was closely linked with disease activity, whereas CLVH was related to the traditional risk factors.https://mrj.ima-press.net/mrj/article/view/1019rheumatoid arthritisleft ventricular remodelingcardiovascular risk factors |
| spellingShingle | I. A. Krivotulova K. V. Korochina T. V. Chernysheva G. E. Kuznetsov L. R. Tenchurina The types of left ventricular remodeling in patients with rheumatoid arthritis Современная ревматология rheumatoid arthritis left ventricular remodeling cardiovascular risk factors |
| title | The types of left ventricular remodeling in patients with rheumatoid arthritis |
| title_full | The types of left ventricular remodeling in patients with rheumatoid arthritis |
| title_fullStr | The types of left ventricular remodeling in patients with rheumatoid arthritis |
| title_full_unstemmed | The types of left ventricular remodeling in patients with rheumatoid arthritis |
| title_short | The types of left ventricular remodeling in patients with rheumatoid arthritis |
| title_sort | types of left ventricular remodeling in patients with rheumatoid arthritis |
| topic | rheumatoid arthritis left ventricular remodeling cardiovascular risk factors |
| url | https://mrj.ima-press.net/mrj/article/view/1019 |
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