Remote ischaemic conditioning for efficacy in patients with aneurysmal subarachnoid haemorrhage (REPAIR): protocol for a multicentre, randomised, double-blind, sham-controlled, parallel-group trial
Introduction A large number of basic and clinical studies have demonstrated that remote ischaemic conditioning (RIC) has neuroprotective effects. Recently, RIC has made gratifying progress in the field of ischaemia stroke treatment. A considerable number of basic and clinical studies have also revea...
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BMJ Publishing Group
2025-08-01
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| Series: | BMJ Open |
| Online Access: | https://bmjopen.bmj.com/content/15/8/e101350.full |
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| author | Yunjian Yin Xunming Ji Aihua Liu Xin Feng Hao Niu Lan Liu Wenbo Zhao Tonghu Jin Liuyu Xu David C Hess |
| author_facet | Yunjian Yin Xunming Ji Aihua Liu Xin Feng Hao Niu Lan Liu Wenbo Zhao Tonghu Jin Liuyu Xu David C Hess |
| author_sort | Yunjian Yin |
| collection | DOAJ |
| description | Introduction A large number of basic and clinical studies have demonstrated that remote ischaemic conditioning (RIC) has neuroprotective effects. Recently, RIC has made gratifying progress in the field of ischaemia stroke treatment. A considerable number of basic and clinical studies have also revealed the possible therapeutic effects of RIC on subarachnoid haemorrhage. However, the neuroprotective effect of RIC on subarachnoid haemorrhage is still lacking convincing evidence and deserves further study.Aim To explore the efficacy and safety of RIC for aneurysmal subarachnoid haemorrhage.Methods and analysis An investigator-initiated, multicentre, randomised, double-blind, sham-controlled, parallel-group trial to evaluate the effect of RIC intervention compared to sham RIC intervention for the neurological function improvement of patients with aneurysmal subarachnoid haemorrhage.Ethics and dissemination The protocol was approved by the IRB of Beijing Tiantan Hospital, Capital Medical University (KY2024-080-03). Progress and safety of the trial are monitored by an independent Data and Safety Monitoring Board. Study results will be published in peer-reviewed medical journals. Written informed consent will be obtained from all participants.Trial registration number NCT06711302. |
| format | Article |
| id | doaj-art-05ed70bdcf114bf99c01c86840ebf323 |
| institution | Kabale University |
| issn | 2044-6055 |
| language | English |
| publishDate | 2025-08-01 |
| publisher | BMJ Publishing Group |
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| series | BMJ Open |
| spelling | doaj-art-05ed70bdcf114bf99c01c86840ebf3232025-08-20T04:02:32ZengBMJ Publishing GroupBMJ Open2044-60552025-08-0115810.1136/bmjopen-2025-101350Remote ischaemic conditioning for efficacy in patients with aneurysmal subarachnoid haemorrhage (REPAIR): protocol for a multicentre, randomised, double-blind, sham-controlled, parallel-group trialYunjian Yin0Xunming Ji1Aihua Liu2Xin Feng3Hao Niu4Lan Liu5Wenbo Zhao6Tonghu Jin7Liuyu Xu8David C Hess9Beijing Institute For Brain Disorders, Beijing, ChinaDepartment of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, ChinaBeijing Neurosurgical Institute, Beijing Tiantan Hospital, Capital Medical University, Beijing, ChinaZhujiang Hospital, Guangzhou, Guangdong, ChinaBeijing Neurosurgical Institute, Beijing Tiantan Hospital, Capital Medical University, Beijing, ChinaBeijing Institute For Brain Disorders, Beijing, ChinaDepartment of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, ChinaBeijing Neurosurgical Institute, Beijing Tiantan Hospital, Capital Medical University, Beijing, ChinaBeijing Neurosurgical Institute, Beijing Tiantan Hospital, Capital Medical University, Beijing, ChinaDepartment of Neurology, Medical College of Georgia, Augusta, Georgia, USAIntroduction A large number of basic and clinical studies have demonstrated that remote ischaemic conditioning (RIC) has neuroprotective effects. Recently, RIC has made gratifying progress in the field of ischaemia stroke treatment. A considerable number of basic and clinical studies have also revealed the possible therapeutic effects of RIC on subarachnoid haemorrhage. However, the neuroprotective effect of RIC on subarachnoid haemorrhage is still lacking convincing evidence and deserves further study.Aim To explore the efficacy and safety of RIC for aneurysmal subarachnoid haemorrhage.Methods and analysis An investigator-initiated, multicentre, randomised, double-blind, sham-controlled, parallel-group trial to evaluate the effect of RIC intervention compared to sham RIC intervention for the neurological function improvement of patients with aneurysmal subarachnoid haemorrhage.Ethics and dissemination The protocol was approved by the IRB of Beijing Tiantan Hospital, Capital Medical University (KY2024-080-03). Progress and safety of the trial are monitored by an independent Data and Safety Monitoring Board. Study results will be published in peer-reviewed medical journals. Written informed consent will be obtained from all participants.Trial registration number NCT06711302.https://bmjopen.bmj.com/content/15/8/e101350.full |
| spellingShingle | Yunjian Yin Xunming Ji Aihua Liu Xin Feng Hao Niu Lan Liu Wenbo Zhao Tonghu Jin Liuyu Xu David C Hess Remote ischaemic conditioning for efficacy in patients with aneurysmal subarachnoid haemorrhage (REPAIR): protocol for a multicentre, randomised, double-blind, sham-controlled, parallel-group trial BMJ Open |
| title | Remote ischaemic conditioning for efficacy in patients with aneurysmal subarachnoid haemorrhage (REPAIR): protocol for a multicentre, randomised, double-blind, sham-controlled, parallel-group trial |
| title_full | Remote ischaemic conditioning for efficacy in patients with aneurysmal subarachnoid haemorrhage (REPAIR): protocol for a multicentre, randomised, double-blind, sham-controlled, parallel-group trial |
| title_fullStr | Remote ischaemic conditioning for efficacy in patients with aneurysmal subarachnoid haemorrhage (REPAIR): protocol for a multicentre, randomised, double-blind, sham-controlled, parallel-group trial |
| title_full_unstemmed | Remote ischaemic conditioning for efficacy in patients with aneurysmal subarachnoid haemorrhage (REPAIR): protocol for a multicentre, randomised, double-blind, sham-controlled, parallel-group trial |
| title_short | Remote ischaemic conditioning for efficacy in patients with aneurysmal subarachnoid haemorrhage (REPAIR): protocol for a multicentre, randomised, double-blind, sham-controlled, parallel-group trial |
| title_sort | remote ischaemic conditioning for efficacy in patients with aneurysmal subarachnoid haemorrhage repair protocol for a multicentre randomised double blind sham controlled parallel group trial |
| url | https://bmjopen.bmj.com/content/15/8/e101350.full |
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