Mammographic density and factors determining it from the point of view of high oncological risks
There is now extensive proof that high percentage of mammographic density (MD) is an independent risk factor for breast cance.r Taking this into account, the research data are summarized with regard to relation of MD to anthropometric, as well as hormonal, genetic and genotoxic factors. There is a n...
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| Language: | Russian |
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2014-08-01
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| Series: | Опухоли женской репродуктивной системы |
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| Online Access: | https://ojrs.abvpress.ru/ojrs/article/view/171 |
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| author | D. A. Vasilyev A. N. Zaitsev L. M. Berstein |
| author_facet | D. A. Vasilyev A. N. Zaitsev L. M. Berstein |
| author_sort | D. A. Vasilyev |
| collection | DOAJ |
| description | There is now extensive proof that high percentage of mammographic density (MD) is an independent risk factor for breast cance.r Taking this into account, the research data are summarized with regard to relation of MD to anthropometric, as well as hormonal, genetic and genotoxic factors. There is a negative correlation between MD and such risk factors as age, number of deliveries, BMI and waist-hip ratio. Most inves- tigations show a direct connection between MD and prolactin level or insulin-like growth factor in blood, mostly in premenopaus al women. Relations of MD with blood estrogens, testosterone, sex hormone binding globulin prove to be too diverse to be taken in account of. It is pos- sible that the action of hormones, especially estrogens, is mediated through their metabolites catecholestrogens and / or reactive oxygen spe- cies. There is certain evidence that a genetic component plays a role in MD. It refers to COMT Val158Met, IGF-I rs6220 A> G and UGT1A1 in premenopausal women, and to ESR1 (XbaI и PvuII) in menopausal cases.Although it is obvious that the risk of breast cancer related to MD is brought about by many factors, there is a necessity for studying addi- tional criteria modifying the process, as well as for searching means for preventing it. |
| format | Article |
| id | doaj-art-05eb7093227147d58ac959cc6d352c1a |
| institution | Kabale University |
| issn | 1994-4098 1999-8627 |
| language | Russian |
| publishDate | 2014-08-01 |
| publisher | ABV-press |
| record_format | Article |
| series | Опухоли женской репродуктивной системы |
| spelling | doaj-art-05eb7093227147d58ac959cc6d352c1a2025-08-20T03:37:11ZrusABV-pressОпухоли женской репродуктивной системы1994-40981999-86272014-08-0103152210.17650/1994-4098-2011-0-3-15-22187Mammographic density and factors determining it from the point of view of high oncological risksD. A. Vasilyev0A. N. Zaitsev1L. M. Berstein2Federal State Institution N.N. Petrov Research Institute of Oncology, Ministry of Health and Social Development, St. PetersburgFederal State Institution N.N. Petrov Research Institute of Oncology, Ministry of Health and Social Development, St. PetersburgFederal State Institution N.N. Petrov Research Institute of Oncology, Ministry of Health and Social Development, St. PetersburgThere is now extensive proof that high percentage of mammographic density (MD) is an independent risk factor for breast cance.r Taking this into account, the research data are summarized with regard to relation of MD to anthropometric, as well as hormonal, genetic and genotoxic factors. There is a negative correlation between MD and such risk factors as age, number of deliveries, BMI and waist-hip ratio. Most inves- tigations show a direct connection between MD and prolactin level or insulin-like growth factor in blood, mostly in premenopaus al women. Relations of MD with blood estrogens, testosterone, sex hormone binding globulin prove to be too diverse to be taken in account of. It is pos- sible that the action of hormones, especially estrogens, is mediated through their metabolites catecholestrogens and / or reactive oxygen spe- cies. There is certain evidence that a genetic component plays a role in MD. It refers to COMT Val158Met, IGF-I rs6220 A> G and UGT1A1 in premenopausal women, and to ESR1 (XbaI и PvuII) in menopausal cases.Although it is obvious that the risk of breast cancer related to MD is brought about by many factors, there is a necessity for studying addi- tional criteria modifying the process, as well as for searching means for preventing it.https://ojrs.abvpress.ru/ojrs/article/view/171breast cancerriskpathogenesismammographic densityestrogensandrogensinsulingenesreactive oxygen species |
| spellingShingle | D. A. Vasilyev A. N. Zaitsev L. M. Berstein Mammographic density and factors determining it from the point of view of high oncological risks Опухоли женской репродуктивной системы breast cancer risk pathogenesis mammographic density estrogens androgens insulin genes reactive oxygen species |
| title | Mammographic density and factors determining it from the point of view of high oncological risks |
| title_full | Mammographic density and factors determining it from the point of view of high oncological risks |
| title_fullStr | Mammographic density and factors determining it from the point of view of high oncological risks |
| title_full_unstemmed | Mammographic density and factors determining it from the point of view of high oncological risks |
| title_short | Mammographic density and factors determining it from the point of view of high oncological risks |
| title_sort | mammographic density and factors determining it from the point of view of high oncological risks |
| topic | breast cancer risk pathogenesis mammographic density estrogens androgens insulin genes reactive oxygen species |
| url | https://ojrs.abvpress.ru/ojrs/article/view/171 |
| work_keys_str_mv | AT davasilyev mammographicdensityandfactorsdeterminingitfromthepointofviewofhighoncologicalrisks AT anzaitsev mammographicdensityandfactorsdeterminingitfromthepointofviewofhighoncologicalrisks AT lmberstein mammographicdensityandfactorsdeterminingitfromthepointofviewofhighoncologicalrisks |