Identifying Drug Prescription in Newly Diagnosed Hypertension Patients in India
ABSTRACT This study evaluated initial antihypertensive drug prescription patterns in Indian healthcare settings. An observational, cross‐sectional, prospective prescription registry analyzed prescriptions for 4723 newly diagnosed hypertension patients. Additionally, it investigated the extent to whi...
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2025-01-01
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| Series: | The Journal of Clinical Hypertension |
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| Online Access: | https://doi.org/10.1111/jch.14963 |
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| author | Thomas Alexander Jagdish S. Hiremath Jitendra P. S. Swahney Subhash Chandra Peeyush Jain Praveen Chandra Nakul Sinha T. Sashikanth Yugandhar Bachhu Anil Balachandran Pathiyil Balagopalan Jayagopal T. Govindan Unni Tiny Nair Kumaresan Kannan Dorairaj Prabhakar M. Chenniappan Ajay U. Mahajan Rajiv D. Karnik Chandrashekhar K. Ponde Prashant Advani Idris Ahmed Khan Brij Mohan Goyal P. R. Vaidyanathan Hiren Prajapati Willem J. Verberk |
| author_facet | Thomas Alexander Jagdish S. Hiremath Jitendra P. S. Swahney Subhash Chandra Peeyush Jain Praveen Chandra Nakul Sinha T. Sashikanth Yugandhar Bachhu Anil Balachandran Pathiyil Balagopalan Jayagopal T. Govindan Unni Tiny Nair Kumaresan Kannan Dorairaj Prabhakar M. Chenniappan Ajay U. Mahajan Rajiv D. Karnik Chandrashekhar K. Ponde Prashant Advani Idris Ahmed Khan Brij Mohan Goyal P. R. Vaidyanathan Hiren Prajapati Willem J. Verberk |
| author_sort | Thomas Alexander |
| collection | DOAJ |
| description | ABSTRACT This study evaluated initial antihypertensive drug prescription patterns in Indian healthcare settings. An observational, cross‐sectional, prospective prescription registry analyzed prescriptions for 4723 newly diagnosed hypertension patients. Additionally, it investigated the extent to which physicians adhered to either European or Indian hypertension guidelines. Angiotensin receptor blockers (ARBs) were the most commonly prescribed drugs, given to 79% of patients, followed by calcium channel blockers (CCBs) at 55%. Diuretics and beta‐blockers (BBs) were prescribed to 27% and 17% of patients, respectively. Monotherapy was administered to 35% of patients, while combination therapies were more prevalent, with dual therapy at 51% and regimens involving three or more drugs prescribed to 14%. Among multi‐drug treatments (n = 3082, 65%), 98% received fixed‐dose combination tablets. The most common combinations were ARB + CCB (26%), ARB + diuretic (12%), and ARB + CCB + diuretic (8%). Key predictors for an increasing number of prescribed drugs included statin use/dyslipidemia, age, blood pressure level, and diabetes. Non‐adherence to hypertension guidelines was evident as 1364 patients classified from moderate to very high risk received monotherapy. Of these, 496 patients had grade 2 or 3 hypertension. Additionally, 88 patients received the undesirable combination of ACEi + ARB, and 267 (15.9%) type 2 diabetes mellitus (T2DM) patients did not receive RAS‐blockers (146 on monotherapy). The findings reveal a trend toward utilizing ARBs, CCBs, and combination tablets, indicating improved adherence to guidelines. However, a significant number of patients did not receive appropriate treatment, highlighting areas for improvement in prescription practices. |
| format | Article |
| id | doaj-art-05ea7420d31040b7824fa1a6ebddc012 |
| institution | Kabale University |
| issn | 1524-6175 1751-7176 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Wiley |
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| series | The Journal of Clinical Hypertension |
| spelling | doaj-art-05ea7420d31040b7824fa1a6ebddc0122025-01-31T05:38:37ZengWileyThe Journal of Clinical Hypertension1524-61751751-71762025-01-01271n/an/a10.1111/jch.14963Identifying Drug Prescription in Newly Diagnosed Hypertension Patients in IndiaThomas Alexander0Jagdish S. Hiremath1Jitendra P. S. Swahney2Subhash Chandra3Peeyush Jain4Praveen Chandra5Nakul Sinha6T. Sashikanth7Yugandhar Bachhu8Anil Balachandran9Pathiyil Balagopalan Jayagopal10T. Govindan Unni11Tiny Nair12Kumaresan Kannan13Dorairaj Prabhakar14M. Chenniappan15Ajay U. Mahajan16Rajiv D. Karnik17Chandrashekhar K. Ponde18Prashant Advani19Idris Ahmed Khan20Brij Mohan Goyal21P. R. Vaidyanathan22Hiren Prajapati23Willem J. Verberk24Department of Interventional Cardiology Kovai Medical Center and Hospital Coimbatore Tamil Nadu IndiaDepartment of Interventional Cardiology Ruby Hall Clinic Pune Maharashtra IndiaDepartment of Cardiology Sir Ganga Ram Hospital New Delhi IndiaDepartment of Interventional Cardiology – Cardiology & Structural Heart Disease Blk‐Max Super Speciality Hospital New Delhi IndiaDepartment of Preventive Cardiology Fortis Hospital Delhi New Delhi IndiaDepartment of Interventional Cardiology Cardiac Care, Medanta Medicity Gurgaon IndiaDepartment of Interventional Cardiology Medanta Heart Institute Lucknow Uttar Pradesh IndiaDepartment of Interventional Cardiology Yashoda Hospitals Secunderabad Telangana IndiaDepartment of Interventional Cardiology Tirupati Andhra Pradesh IndiaDepartment of Interventional Cardiology Lakshmi Hospital Cochin Kerala IndiaDepartment of Cardiology Lakshmi Hospital Palakkad Kerala IndiaDepartment of Cardiology Jubilee Mission Medical College & Research Institute Thrissur Kerala IndiaDepartment of Cardiology PRS Hospital, Killipalam Trivandrum Kerala IndiaDepartment of Cardiology Aswene Soundra Hospital and Research Centre Chennai IndiaDepartment of Interventional Cardiology Apollo Firstmed Hospital, Consultant Cardiologist, Ashwin Clinic Chennai IndiaIMA College of General Practitioners Trichy IndiaDepartment of Cardiology G.S. Medical College & K.E.M Hospital Mumbai USADepartment of Interventional Cardiology Cath Interventions, Fortis Hospital Mumbai Maharashtra IndiaDepartment of Cardiology Hinduja Hospital and Medical Research Centre Mumbai Maharashtra IndiaDepartment of Cardiology Advani Heartline Raipur Chhattisgarh IndiaDepartment of Interventional Cardiology Bombay Hospital Indore Madhya Pradesh IndiaCardiac Science Apex Hospital Jaipur Rajasthan IndiaDepartment of Cardiology Hindusthan Hospital Coimbatore Tamil Nadu IndiaDepartment of Medical Affairs Eris Lifesciences Ltd. Ahmedabad Gujarat IndiaCARIM School for Cardiovascular Diseases Maastricht University Maastricht The NetherlandsABSTRACT This study evaluated initial antihypertensive drug prescription patterns in Indian healthcare settings. An observational, cross‐sectional, prospective prescription registry analyzed prescriptions for 4723 newly diagnosed hypertension patients. Additionally, it investigated the extent to which physicians adhered to either European or Indian hypertension guidelines. Angiotensin receptor blockers (ARBs) were the most commonly prescribed drugs, given to 79% of patients, followed by calcium channel blockers (CCBs) at 55%. Diuretics and beta‐blockers (BBs) were prescribed to 27% and 17% of patients, respectively. Monotherapy was administered to 35% of patients, while combination therapies were more prevalent, with dual therapy at 51% and regimens involving three or more drugs prescribed to 14%. Among multi‐drug treatments (n = 3082, 65%), 98% received fixed‐dose combination tablets. The most common combinations were ARB + CCB (26%), ARB + diuretic (12%), and ARB + CCB + diuretic (8%). Key predictors for an increasing number of prescribed drugs included statin use/dyslipidemia, age, blood pressure level, and diabetes. Non‐adherence to hypertension guidelines was evident as 1364 patients classified from moderate to very high risk received monotherapy. Of these, 496 patients had grade 2 or 3 hypertension. Additionally, 88 patients received the undesirable combination of ACEi + ARB, and 267 (15.9%) type 2 diabetes mellitus (T2DM) patients did not receive RAS‐blockers (146 on monotherapy). The findings reveal a trend toward utilizing ARBs, CCBs, and combination tablets, indicating improved adherence to guidelines. However, a significant number of patients did not receive appropriate treatment, highlighting areas for improvement in prescription practices.https://doi.org/10.1111/jch.14963antihypertensive therapyclinical management of high blood pressure (HBP)clinical pharmacologycombination therapyepidemiology |
| spellingShingle | Thomas Alexander Jagdish S. Hiremath Jitendra P. S. Swahney Subhash Chandra Peeyush Jain Praveen Chandra Nakul Sinha T. Sashikanth Yugandhar Bachhu Anil Balachandran Pathiyil Balagopalan Jayagopal T. Govindan Unni Tiny Nair Kumaresan Kannan Dorairaj Prabhakar M. Chenniappan Ajay U. Mahajan Rajiv D. Karnik Chandrashekhar K. Ponde Prashant Advani Idris Ahmed Khan Brij Mohan Goyal P. R. Vaidyanathan Hiren Prajapati Willem J. Verberk Identifying Drug Prescription in Newly Diagnosed Hypertension Patients in India The Journal of Clinical Hypertension antihypertensive therapy clinical management of high blood pressure (HBP) clinical pharmacology combination therapy epidemiology |
| title | Identifying Drug Prescription in Newly Diagnosed Hypertension Patients in India |
| title_full | Identifying Drug Prescription in Newly Diagnosed Hypertension Patients in India |
| title_fullStr | Identifying Drug Prescription in Newly Diagnosed Hypertension Patients in India |
| title_full_unstemmed | Identifying Drug Prescription in Newly Diagnosed Hypertension Patients in India |
| title_short | Identifying Drug Prescription in Newly Diagnosed Hypertension Patients in India |
| title_sort | identifying drug prescription in newly diagnosed hypertension patients in india |
| topic | antihypertensive therapy clinical management of high blood pressure (HBP) clinical pharmacology combination therapy epidemiology |
| url | https://doi.org/10.1111/jch.14963 |
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