A systematic review of the predictive factors for the recurrence of acute pancreatitis
Abstract Purpose Acute Pancreatitis (AP) is a prevalent clinical pancreatic disorder characterized by acute inflammation of the pancreas, frequently associated with biliary or alcoholic events. If not treated with cholecystectomy after the first episode, patients may experience a recurrence of AP, w...
Saved in:
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2025-04-01
|
| Series: | World Journal of Emergency Surgery |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s13017-025-00601-x |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849726384295903232 |
|---|---|
| author | Daniela Pacella Adriano De Simone Adolfo Pisanu Gianluca Pellino Lucio Selvaggi Valentina Murzi Eleonora Locci Giulia Ciabatti Laura Mastrangelo Elio Jovine Matteo Rottoli Giacomo Calini Stefano Cardelli Fausto Catena Carlo Vallicelli Raffaele Bova Gabriele Vigutto Fabrizio D’Acapito Giorgio Ercolani Leonardo Solaini Alan Biloslavo Paola Germani Camilla Colutta Pasquale Lepiane Rosa Scaramuzzo Savino Occhionorelli Domenico Lacavalla Maria Grazia Sibilla Stefano Olmi Matteo Uccelli Alberto Oldani Alessio Giordano Tommaso Guagni Davina Perini Francesco Pata Bruno Nardo Daniele Paglione Giusi Franco Matteo Donadon Marcello Di Martino Salomone Di Saverio Luca Cardinali Grazia Travaglini Dario Bruzzese Mauro Podda |
| author_facet | Daniela Pacella Adriano De Simone Adolfo Pisanu Gianluca Pellino Lucio Selvaggi Valentina Murzi Eleonora Locci Giulia Ciabatti Laura Mastrangelo Elio Jovine Matteo Rottoli Giacomo Calini Stefano Cardelli Fausto Catena Carlo Vallicelli Raffaele Bova Gabriele Vigutto Fabrizio D’Acapito Giorgio Ercolani Leonardo Solaini Alan Biloslavo Paola Germani Camilla Colutta Pasquale Lepiane Rosa Scaramuzzo Savino Occhionorelli Domenico Lacavalla Maria Grazia Sibilla Stefano Olmi Matteo Uccelli Alberto Oldani Alessio Giordano Tommaso Guagni Davina Perini Francesco Pata Bruno Nardo Daniele Paglione Giusi Franco Matteo Donadon Marcello Di Martino Salomone Di Saverio Luca Cardinali Grazia Travaglini Dario Bruzzese Mauro Podda |
| author_sort | Daniela Pacella |
| collection | DOAJ |
| description | Abstract Purpose Acute Pancreatitis (AP) is a prevalent clinical pancreatic disorder characterized by acute inflammation of the pancreas, frequently associated with biliary or alcoholic events. If not treated with cholecystectomy after the first episode, patients may experience a recurrence of AP, with consequent need for emergency surgery and increased risk of death. Analyzing the risk factors that may contribute to the recurrence of Biliary and Alcoholic Pancreatitis (BAP and AAP), future research can be driven toward new solutions for preventing and treating this pancreatic disease. Methods A systematic review was conducted selecting studies from BiomedCentral, PubMed, Scopus and Web of Science by two independent reviewers. Publications were considered only if written in English in the time interval between January 2000 and June 2024 and investigated the risk factors for the recurrence of BAP and AAP. At the end of the selection, a quality assessment phase was conducted using the PROBAST tool. Results In this systematic review, 8 articles were selected out of 6.945, involving a total sample of 11.271 patients of which 38.77% developed recurrence episodes. 37.5% of the included studies focus on recurrent acute biliary pancreatitis (RBAP), while 62.5% are dedicated to recurrent acute alcoholic pancreatitis (RAAP). The risk factors for the recurrence of AP showed a clear differentiation between the alcoholic and biliary etiology. Most of the considered studies adopted a retrospective design, characterized by a susceptibility to potential methodological biases. However, the trend indicated a more recent increase in prospective studies, together with a greater focus on identifying and understanding the possible risk factors associated with the recurrence of acute pancreatitis (RAP). This result highlighted the progress in the scientific approach toward a more rigorous and systematic assessment of the causes and dynamics that influence the recurrence of the disease. Conclusion Studies highlighted the importance of lifestyle factors, clinical complications, and surgical interventions that can impact the risk of biliary or alcoholic recurrent acute pancreatitis. Increased and systematic adoption of artificial intelligence-based tools could significantly impact future knowledge relating to the risks of recurrence and relative possibilities of prevention. |
| format | Article |
| id | doaj-art-05e8fda86de44ae7a60b97d2ee60b817 |
| institution | DOAJ |
| issn | 1749-7922 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | BMC |
| record_format | Article |
| series | World Journal of Emergency Surgery |
| spelling | doaj-art-05e8fda86de44ae7a60b97d2ee60b8172025-08-20T03:10:11ZengBMCWorld Journal of Emergency Surgery1749-79222025-04-0120111310.1186/s13017-025-00601-xA systematic review of the predictive factors for the recurrence of acute pancreatitisDaniela Pacella0Adriano De Simone1Adolfo Pisanu2Gianluca Pellino3Lucio Selvaggi4Valentina Murzi5Eleonora Locci6Giulia Ciabatti7Laura Mastrangelo8Elio Jovine9Matteo Rottoli10Giacomo Calini11Stefano Cardelli12Fausto Catena13Carlo Vallicelli14Raffaele Bova15Gabriele Vigutto16Fabrizio D’Acapito17Giorgio Ercolani18Leonardo Solaini19Alan Biloslavo20Paola Germani21Camilla Colutta22Pasquale Lepiane23Rosa Scaramuzzo24Savino Occhionorelli25Domenico Lacavalla26Maria Grazia Sibilla27Stefano Olmi28Matteo Uccelli29Alberto Oldani30Alessio Giordano31Tommaso Guagni32Davina Perini33Francesco Pata34Bruno Nardo35Daniele Paglione36Giusi Franco37Matteo Donadon38Marcello Di Martino39Salomone Di Saverio40Luca Cardinali41Grazia Travaglini42Dario Bruzzese43Mauro Podda44Department of Public Health, University of Naples Federico IIDepartment of Public Health, University of Naples Federico IIEmergency Surgery Unit, Department of Surgical Science, University of CagliariDepartment of Advanced Medical and Surgical Sciences, University of Campania “Luigi Vanvitelli”Department of Advanced Medical and Surgical Sciences, University of Campania “Luigi Vanvitelli”Emergency Surgery Unit, Department of Surgical Science, University of CagliariEmergency Surgery Unit, Department of Surgical Science, University of CagliariDepartment of Medical and Surgical Science, University of Bologna, Maggiore HospitalDepartment of Medical and Surgical Science, University of Bologna, Maggiore HospitalDepartment of Medical and Surgical Science, University of Bologna, Maggiore HospitalDepartment of Medical and Surgical Science, University of Bologna, Sant’Orsola HospitalDepartment of Medical and Surgical Science, University of Bologna, Sant’Orsola HospitalDepartment of Medical and Surgical Science, University of Bologna, Sant’Orsola HospitalDepartment of General, Emergency and Trauma Surgery, Bufalini HospitalDepartment of General, Emergency and Trauma Surgery, Bufalini HospitalDepartment of General, Emergency and Trauma Surgery, Bufalini HospitalDepartment of General, Emergency and Trauma Surgery, Bufalini HospitalDepartment of Medical and Surgical Science, University of Bologna, Morgagni-Pierantoni Hospital ForlìDepartment of Medical and Surgical Science, University of Bologna, Morgagni-Pierantoni Hospital ForlìDepartment of Medical and Surgical Science, University of Bologna, Morgagni-Pierantoni Hospital ForlìDepartment of General Surgery, Azienda Sanitaria Universitaria Giuliano Isontina, University of TriesteDepartment of General Surgery, Azienda Sanitaria Universitaria Giuliano Isontina, University of TriesteDepartment of General Surgery, Azienda Sanitaria Universitaria Giuliano Isontina, University of TriesteDepartment of Surgery, San Paolo Hospital CivitavecchiaDepartment of Surgery, San Paolo Hospital CivitavecchiaDepartment of Morphology, Surgery and Experimental Medicine, University of FerraraDepartment of Morphology, Surgery and Experimental Medicine, University of FerraraDepartment of Morphology, Surgery and Experimental Medicine, University of FerraraDepartment of General Surgery, San Donato Hospital ZingoniaDepartment of General Surgery, San Donato Hospital ZingoniaDepartment of General Surgery, San Donato Hospital ZingoniaDepartment of Emergency Surgery, Careggi HospitalDepartment of Emergency Surgery, Careggi HospitalDepartment of Emergency Surgery, Careggi HospitalDepartment of Pharmacy, Health and Nutritional Sciences, University of CalabriaDepartment of Pharmacy, Health and Nutritional Sciences, University of CalabriaDepartment of Pharmacy, Health and Nutritional Sciences, University of CalabriaDepartment of Pharmacy, Health and Nutritional Sciences, University of CalabriaDepartment of Health Science, University of Piemonte Orientale, Ospedale Maggiore della CaritàDepartment of Health Science, University of Piemonte Orientale, Ospedale Maggiore della CaritàDepartment of Surgery, Madonna del Soccorso HospitalDepartment of Surgery, Madonna del Soccorso HospitalDepartment of Surgery, Madonna del Soccorso HospitalDepartment of Public Health, University of Naples Federico IIEmergency Surgery Unit, Department of Surgical Science, University of CagliariAbstract Purpose Acute Pancreatitis (AP) is a prevalent clinical pancreatic disorder characterized by acute inflammation of the pancreas, frequently associated with biliary or alcoholic events. If not treated with cholecystectomy after the first episode, patients may experience a recurrence of AP, with consequent need for emergency surgery and increased risk of death. Analyzing the risk factors that may contribute to the recurrence of Biliary and Alcoholic Pancreatitis (BAP and AAP), future research can be driven toward new solutions for preventing and treating this pancreatic disease. Methods A systematic review was conducted selecting studies from BiomedCentral, PubMed, Scopus and Web of Science by two independent reviewers. Publications were considered only if written in English in the time interval between January 2000 and June 2024 and investigated the risk factors for the recurrence of BAP and AAP. At the end of the selection, a quality assessment phase was conducted using the PROBAST tool. Results In this systematic review, 8 articles were selected out of 6.945, involving a total sample of 11.271 patients of which 38.77% developed recurrence episodes. 37.5% of the included studies focus on recurrent acute biliary pancreatitis (RBAP), while 62.5% are dedicated to recurrent acute alcoholic pancreatitis (RAAP). The risk factors for the recurrence of AP showed a clear differentiation between the alcoholic and biliary etiology. Most of the considered studies adopted a retrospective design, characterized by a susceptibility to potential methodological biases. However, the trend indicated a more recent increase in prospective studies, together with a greater focus on identifying and understanding the possible risk factors associated with the recurrence of acute pancreatitis (RAP). This result highlighted the progress in the scientific approach toward a more rigorous and systematic assessment of the causes and dynamics that influence the recurrence of the disease. Conclusion Studies highlighted the importance of lifestyle factors, clinical complications, and surgical interventions that can impact the risk of biliary or alcoholic recurrent acute pancreatitis. Increased and systematic adoption of artificial intelligence-based tools could significantly impact future knowledge relating to the risks of recurrence and relative possibilities of prevention.https://doi.org/10.1186/s13017-025-00601-xRisk factorsAcute PancreatitisRecurrenceBiliaryAlcoholic |
| spellingShingle | Daniela Pacella Adriano De Simone Adolfo Pisanu Gianluca Pellino Lucio Selvaggi Valentina Murzi Eleonora Locci Giulia Ciabatti Laura Mastrangelo Elio Jovine Matteo Rottoli Giacomo Calini Stefano Cardelli Fausto Catena Carlo Vallicelli Raffaele Bova Gabriele Vigutto Fabrizio D’Acapito Giorgio Ercolani Leonardo Solaini Alan Biloslavo Paola Germani Camilla Colutta Pasquale Lepiane Rosa Scaramuzzo Savino Occhionorelli Domenico Lacavalla Maria Grazia Sibilla Stefano Olmi Matteo Uccelli Alberto Oldani Alessio Giordano Tommaso Guagni Davina Perini Francesco Pata Bruno Nardo Daniele Paglione Giusi Franco Matteo Donadon Marcello Di Martino Salomone Di Saverio Luca Cardinali Grazia Travaglini Dario Bruzzese Mauro Podda A systematic review of the predictive factors for the recurrence of acute pancreatitis World Journal of Emergency Surgery Risk factors Acute Pancreatitis Recurrence Biliary Alcoholic |
| title | A systematic review of the predictive factors for the recurrence of acute pancreatitis |
| title_full | A systematic review of the predictive factors for the recurrence of acute pancreatitis |
| title_fullStr | A systematic review of the predictive factors for the recurrence of acute pancreatitis |
| title_full_unstemmed | A systematic review of the predictive factors for the recurrence of acute pancreatitis |
| title_short | A systematic review of the predictive factors for the recurrence of acute pancreatitis |
| title_sort | systematic review of the predictive factors for the recurrence of acute pancreatitis |
| topic | Risk factors Acute Pancreatitis Recurrence Biliary Alcoholic |
| url | https://doi.org/10.1186/s13017-025-00601-x |
| work_keys_str_mv | AT danielapacella asystematicreviewofthepredictivefactorsfortherecurrenceofacutepancreatitis AT adrianodesimone asystematicreviewofthepredictivefactorsfortherecurrenceofacutepancreatitis AT adolfopisanu asystematicreviewofthepredictivefactorsfortherecurrenceofacutepancreatitis AT gianlucapellino asystematicreviewofthepredictivefactorsfortherecurrenceofacutepancreatitis AT lucioselvaggi asystematicreviewofthepredictivefactorsfortherecurrenceofacutepancreatitis AT valentinamurzi asystematicreviewofthepredictivefactorsfortherecurrenceofacutepancreatitis AT eleonoralocci asystematicreviewofthepredictivefactorsfortherecurrenceofacutepancreatitis AT giuliaciabatti asystematicreviewofthepredictivefactorsfortherecurrenceofacutepancreatitis AT lauramastrangelo asystematicreviewofthepredictivefactorsfortherecurrenceofacutepancreatitis AT eliojovine asystematicreviewofthepredictivefactorsfortherecurrenceofacutepancreatitis AT matteorottoli asystematicreviewofthepredictivefactorsfortherecurrenceofacutepancreatitis AT giacomocalini asystematicreviewofthepredictivefactorsfortherecurrenceofacutepancreatitis AT stefanocardelli asystematicreviewofthepredictivefactorsfortherecurrenceofacutepancreatitis AT faustocatena asystematicreviewofthepredictivefactorsfortherecurrenceofacutepancreatitis AT carlovallicelli asystematicreviewofthepredictivefactorsfortherecurrenceofacutepancreatitis AT raffaelebova asystematicreviewofthepredictivefactorsfortherecurrenceofacutepancreatitis AT gabrielevigutto asystematicreviewofthepredictivefactorsfortherecurrenceofacutepancreatitis AT fabriziodacapito asystematicreviewofthepredictivefactorsfortherecurrenceofacutepancreatitis AT giorgioercolani asystematicreviewofthepredictivefactorsfortherecurrenceofacutepancreatitis AT leonardosolaini asystematicreviewofthepredictivefactorsfortherecurrenceofacutepancreatitis AT alanbiloslavo asystematicreviewofthepredictivefactorsfortherecurrenceofacutepancreatitis AT paolagermani asystematicreviewofthepredictivefactorsfortherecurrenceofacutepancreatitis AT camillacolutta asystematicreviewofthepredictivefactorsfortherecurrenceofacutepancreatitis AT pasqualelepiane asystematicreviewofthepredictivefactorsfortherecurrenceofacutepancreatitis AT rosascaramuzzo asystematicreviewofthepredictivefactorsfortherecurrenceofacutepancreatitis AT savinoocchionorelli asystematicreviewofthepredictivefactorsfortherecurrenceofacutepancreatitis AT domenicolacavalla asystematicreviewofthepredictivefactorsfortherecurrenceofacutepancreatitis AT mariagraziasibilla asystematicreviewofthepredictivefactorsfortherecurrenceofacutepancreatitis AT stefanoolmi asystematicreviewofthepredictivefactorsfortherecurrenceofacutepancreatitis AT matteouccelli asystematicreviewofthepredictivefactorsfortherecurrenceofacutepancreatitis AT albertooldani asystematicreviewofthepredictivefactorsfortherecurrenceofacutepancreatitis AT alessiogiordano asystematicreviewofthepredictivefactorsfortherecurrenceofacutepancreatitis AT tommasoguagni asystematicreviewofthepredictivefactorsfortherecurrenceofacutepancreatitis AT davinaperini asystematicreviewofthepredictivefactorsfortherecurrenceofacutepancreatitis AT francescopata asystematicreviewofthepredictivefactorsfortherecurrenceofacutepancreatitis AT brunonardo asystematicreviewofthepredictivefactorsfortherecurrenceofacutepancreatitis AT danielepaglione asystematicreviewofthepredictivefactorsfortherecurrenceofacutepancreatitis AT giusifranco asystematicreviewofthepredictivefactorsfortherecurrenceofacutepancreatitis AT matteodonadon asystematicreviewofthepredictivefactorsfortherecurrenceofacutepancreatitis AT marcellodimartino asystematicreviewofthepredictivefactorsfortherecurrenceofacutepancreatitis AT salomonedisaverio asystematicreviewofthepredictivefactorsfortherecurrenceofacutepancreatitis AT lucacardinali asystematicreviewofthepredictivefactorsfortherecurrenceofacutepancreatitis AT graziatravaglini asystematicreviewofthepredictivefactorsfortherecurrenceofacutepancreatitis AT dariobruzzese asystematicreviewofthepredictivefactorsfortherecurrenceofacutepancreatitis AT mauropodda asystematicreviewofthepredictivefactorsfortherecurrenceofacutepancreatitis AT danielapacella systematicreviewofthepredictivefactorsfortherecurrenceofacutepancreatitis AT adrianodesimone systematicreviewofthepredictivefactorsfortherecurrenceofacutepancreatitis AT adolfopisanu systematicreviewofthepredictivefactorsfortherecurrenceofacutepancreatitis AT gianlucapellino systematicreviewofthepredictivefactorsfortherecurrenceofacutepancreatitis AT lucioselvaggi systematicreviewofthepredictivefactorsfortherecurrenceofacutepancreatitis AT valentinamurzi systematicreviewofthepredictivefactorsfortherecurrenceofacutepancreatitis AT eleonoralocci systematicreviewofthepredictivefactorsfortherecurrenceofacutepancreatitis AT giuliaciabatti systematicreviewofthepredictivefactorsfortherecurrenceofacutepancreatitis AT lauramastrangelo systematicreviewofthepredictivefactorsfortherecurrenceofacutepancreatitis AT eliojovine systematicreviewofthepredictivefactorsfortherecurrenceofacutepancreatitis AT matteorottoli systematicreviewofthepredictivefactorsfortherecurrenceofacutepancreatitis AT giacomocalini systematicreviewofthepredictivefactorsfortherecurrenceofacutepancreatitis AT stefanocardelli systematicreviewofthepredictivefactorsfortherecurrenceofacutepancreatitis AT faustocatena systematicreviewofthepredictivefactorsfortherecurrenceofacutepancreatitis AT carlovallicelli systematicreviewofthepredictivefactorsfortherecurrenceofacutepancreatitis AT raffaelebova systematicreviewofthepredictivefactorsfortherecurrenceofacutepancreatitis AT gabrielevigutto systematicreviewofthepredictivefactorsfortherecurrenceofacutepancreatitis AT fabriziodacapito systematicreviewofthepredictivefactorsfortherecurrenceofacutepancreatitis AT giorgioercolani systematicreviewofthepredictivefactorsfortherecurrenceofacutepancreatitis AT leonardosolaini systematicreviewofthepredictivefactorsfortherecurrenceofacutepancreatitis AT alanbiloslavo systematicreviewofthepredictivefactorsfortherecurrenceofacutepancreatitis AT paolagermani systematicreviewofthepredictivefactorsfortherecurrenceofacutepancreatitis AT camillacolutta systematicreviewofthepredictivefactorsfortherecurrenceofacutepancreatitis AT pasqualelepiane systematicreviewofthepredictivefactorsfortherecurrenceofacutepancreatitis AT rosascaramuzzo systematicreviewofthepredictivefactorsfortherecurrenceofacutepancreatitis AT savinoocchionorelli systematicreviewofthepredictivefactorsfortherecurrenceofacutepancreatitis AT domenicolacavalla systematicreviewofthepredictivefactorsfortherecurrenceofacutepancreatitis AT mariagraziasibilla systematicreviewofthepredictivefactorsfortherecurrenceofacutepancreatitis AT stefanoolmi systematicreviewofthepredictivefactorsfortherecurrenceofacutepancreatitis AT matteouccelli systematicreviewofthepredictivefactorsfortherecurrenceofacutepancreatitis AT albertooldani systematicreviewofthepredictivefactorsfortherecurrenceofacutepancreatitis AT alessiogiordano systematicreviewofthepredictivefactorsfortherecurrenceofacutepancreatitis AT tommasoguagni systematicreviewofthepredictivefactorsfortherecurrenceofacutepancreatitis AT davinaperini systematicreviewofthepredictivefactorsfortherecurrenceofacutepancreatitis AT francescopata systematicreviewofthepredictivefactorsfortherecurrenceofacutepancreatitis AT brunonardo systematicreviewofthepredictivefactorsfortherecurrenceofacutepancreatitis AT danielepaglione systematicreviewofthepredictivefactorsfortherecurrenceofacutepancreatitis AT giusifranco systematicreviewofthepredictivefactorsfortherecurrenceofacutepancreatitis AT matteodonadon systematicreviewofthepredictivefactorsfortherecurrenceofacutepancreatitis AT marcellodimartino systematicreviewofthepredictivefactorsfortherecurrenceofacutepancreatitis AT salomonedisaverio systematicreviewofthepredictivefactorsfortherecurrenceofacutepancreatitis AT lucacardinali systematicreviewofthepredictivefactorsfortherecurrenceofacutepancreatitis AT graziatravaglini systematicreviewofthepredictivefactorsfortherecurrenceofacutepancreatitis AT dariobruzzese systematicreviewofthepredictivefactorsfortherecurrenceofacutepancreatitis AT mauropodda systematicreviewofthepredictivefactorsfortherecurrenceofacutepancreatitis |