Aluminum Poisoning with Emphasis on Its Mechanism and Treatment of Intoxication
Aluminum poisoning has been reported in some parts of the world. It is one of the global health problems that affect many organs. Aluminum is widely used daily by humans and industries. Residues of aluminum compounds can be found in drinking water, food, air, medicine, deodorants, cosmetics, packagi...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2022-01-01
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| Series: | Emergency Medicine International |
| Online Access: | http://dx.doi.org/10.1155/2022/1480553 |
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| author | Mehrdad Rafati Rahimzadeh Mehravar Rafati Rahimzadeh Sohrab Kazemi Roghayeh Jafarian Amiri Marzieh Pirzadeh Ali Akbar Moghadamnia |
| author_facet | Mehrdad Rafati Rahimzadeh Mehravar Rafati Rahimzadeh Sohrab Kazemi Roghayeh Jafarian Amiri Marzieh Pirzadeh Ali Akbar Moghadamnia |
| author_sort | Mehrdad Rafati Rahimzadeh |
| collection | DOAJ |
| description | Aluminum poisoning has been reported in some parts of the world. It is one of the global health problems that affect many organs. Aluminum is widely used daily by humans and industries. Residues of aluminum compounds can be found in drinking water, food, air, medicine, deodorants, cosmetics, packaging, many appliances and equipment, buildings, transportation industries, and aerospace engineering. Exposure to high levels of aluminum compounds leads to aluminum poisoning. Aluminum poisoning has complex and multidimensional effects, such as disruption or inhibition of enzymes activities, changing protein synthesis, nucleic acid function, and cell membrane permeability, preventing DNA repair, altering the stability of DNA organization, inhibition of the protein phosphatase 2A (PP2A) activity, increasing reactive oxygen species (ROS) production, inducing oxidative stress, decreasing activity of antioxidant enzymes, altering cellular iron homeostasis, and changing NF-kB, p53, and JNK pathway leading to apoptosis. Aluminum poisoning can affect blood content, musculoskeletal system, kidney, liver, and respiratory and nervous system, and the extent of poisoning can be diagnosed by assaying aluminum compounds in blood, urine, hair, nails, and sweat. Chelator agents such as deferoxamine (DFO) are used in the case of aluminum poisoning. Besides, combination therapies are recommended. |
| format | Article |
| id | doaj-art-05e66cd967124cef8866038f5387b77e |
| institution | Kabale University |
| issn | 2090-2859 |
| language | English |
| publishDate | 2022-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Emergency Medicine International |
| spelling | doaj-art-05e66cd967124cef8866038f5387b77e2025-02-03T06:11:18ZengWileyEmergency Medicine International2090-28592022-01-01202210.1155/2022/1480553Aluminum Poisoning with Emphasis on Its Mechanism and Treatment of IntoxicationMehrdad Rafati Rahimzadeh0Mehravar Rafati Rahimzadeh1Sohrab Kazemi2Roghayeh Jafarian Amiri3Marzieh Pirzadeh4Ali Akbar Moghadamnia5Department of NursingDepartment of Medical PhysicsCellular and Molecular Biology Research CenterDepartment of NursingStudent Research CommitteeDepartment of PharmacologyAluminum poisoning has been reported in some parts of the world. It is one of the global health problems that affect many organs. Aluminum is widely used daily by humans and industries. Residues of aluminum compounds can be found in drinking water, food, air, medicine, deodorants, cosmetics, packaging, many appliances and equipment, buildings, transportation industries, and aerospace engineering. Exposure to high levels of aluminum compounds leads to aluminum poisoning. Aluminum poisoning has complex and multidimensional effects, such as disruption or inhibition of enzymes activities, changing protein synthesis, nucleic acid function, and cell membrane permeability, preventing DNA repair, altering the stability of DNA organization, inhibition of the protein phosphatase 2A (PP2A) activity, increasing reactive oxygen species (ROS) production, inducing oxidative stress, decreasing activity of antioxidant enzymes, altering cellular iron homeostasis, and changing NF-kB, p53, and JNK pathway leading to apoptosis. Aluminum poisoning can affect blood content, musculoskeletal system, kidney, liver, and respiratory and nervous system, and the extent of poisoning can be diagnosed by assaying aluminum compounds in blood, urine, hair, nails, and sweat. Chelator agents such as deferoxamine (DFO) are used in the case of aluminum poisoning. Besides, combination therapies are recommended.http://dx.doi.org/10.1155/2022/1480553 |
| spellingShingle | Mehrdad Rafati Rahimzadeh Mehravar Rafati Rahimzadeh Sohrab Kazemi Roghayeh Jafarian Amiri Marzieh Pirzadeh Ali Akbar Moghadamnia Aluminum Poisoning with Emphasis on Its Mechanism and Treatment of Intoxication Emergency Medicine International |
| title | Aluminum Poisoning with Emphasis on Its Mechanism and Treatment of Intoxication |
| title_full | Aluminum Poisoning with Emphasis on Its Mechanism and Treatment of Intoxication |
| title_fullStr | Aluminum Poisoning with Emphasis on Its Mechanism and Treatment of Intoxication |
| title_full_unstemmed | Aluminum Poisoning with Emphasis on Its Mechanism and Treatment of Intoxication |
| title_short | Aluminum Poisoning with Emphasis on Its Mechanism and Treatment of Intoxication |
| title_sort | aluminum poisoning with emphasis on its mechanism and treatment of intoxication |
| url | http://dx.doi.org/10.1155/2022/1480553 |
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