Association between hyperlipidemia and postoperative delirium risk: a systematic review and meta-analysis
IntroductionThe association between hyperlipidemia and its potential role as a risk factor for postoperative delirium (POD) remains unclear.MethodsWe systematically searched PubMed, Embase, Web of Science, Cochrane Library, and ClinicalTrials.gov to identify studies meeting the inclusion criteria. O...
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Frontiers Media S.A.
2025-03-01
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| Series: | Frontiers in Aging Neuroscience |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnagi.2025.1544838/full |
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| author | Li-quan Qiu Jian-li Song Li-cai Zhang Bin Fan Qiang Li Bin Lu Guan-yu Chen |
| author_facet | Li-quan Qiu Jian-li Song Li-cai Zhang Bin Fan Qiang Li Bin Lu Guan-yu Chen |
| author_sort | Li-quan Qiu |
| collection | DOAJ |
| description | IntroductionThe association between hyperlipidemia and its potential role as a risk factor for postoperative delirium (POD) remains unclear.MethodsWe systematically searched PubMed, Embase, Web of Science, Cochrane Library, and ClinicalTrials.gov to identify studies meeting the inclusion criteria. Outcomes of interest included comparisons of blood lipid levels between POD and non-POD (NPOD) patients, the association between hyperlipidemia and POD risk, and the predictive value of hyperlipidemia for POD.ResultsA total of nine studies involving 4,686 patients were included in the meta-analysis. Pooled analysis revealed that hyperlipidemia was significantly associated with an increased risk of POD (OR = 1.47; 95% CI 1.13–1.91; P = 0.004;) compared to patients without hyperlipidemia. Patients with POD exhibited significantly higher levels of total cholesterol (TC) (weighted mean difference [WMD] = 0.31; 95% CI 0.03–0.59; P = 0.030), triglycerides (TG) (WMD = 0.37; 95% CI 0.03–0.71; P = 0.033), and low-density lipoprotein cholesterol (LDL-C) (WMD = 0.09; 95% CI 0.01–0.17; P = 0.023) compared to NPOD patients. In contrast, high-density lipoprotein cholesterol (HDL-C) levels were significantly lower in POD patients (WMD = −0.07; 95% CI −0.12 to −0.01; P = 0.026). Insufficient evidence was available to summarize the area under the curve (AUC) results.ConclusionsBlood lipid levels were significantly elevated in POD patients compared to NPOD patients. Hyperlipidemia was significantly associated with an increased risk of POD, highlighting its potential role as a risk factor. |
| format | Article |
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| institution | DOAJ |
| issn | 1663-4365 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Aging Neuroscience |
| spelling | doaj-art-05e1d7e6d7634d9092d72eaa7676665b2025-08-20T02:56:36ZengFrontiers Media S.A.Frontiers in Aging Neuroscience1663-43652025-03-011710.3389/fnagi.2025.15448381544838Association between hyperlipidemia and postoperative delirium risk: a systematic review and meta-analysisLi-quan QiuJian-li SongLi-cai ZhangBin FanQiang LiBin LuGuan-yu ChenIntroductionThe association between hyperlipidemia and its potential role as a risk factor for postoperative delirium (POD) remains unclear.MethodsWe systematically searched PubMed, Embase, Web of Science, Cochrane Library, and ClinicalTrials.gov to identify studies meeting the inclusion criteria. Outcomes of interest included comparisons of blood lipid levels between POD and non-POD (NPOD) patients, the association between hyperlipidemia and POD risk, and the predictive value of hyperlipidemia for POD.ResultsA total of nine studies involving 4,686 patients were included in the meta-analysis. Pooled analysis revealed that hyperlipidemia was significantly associated with an increased risk of POD (OR = 1.47; 95% CI 1.13–1.91; P = 0.004;) compared to patients without hyperlipidemia. Patients with POD exhibited significantly higher levels of total cholesterol (TC) (weighted mean difference [WMD] = 0.31; 95% CI 0.03–0.59; P = 0.030), triglycerides (TG) (WMD = 0.37; 95% CI 0.03–0.71; P = 0.033), and low-density lipoprotein cholesterol (LDL-C) (WMD = 0.09; 95% CI 0.01–0.17; P = 0.023) compared to NPOD patients. In contrast, high-density lipoprotein cholesterol (HDL-C) levels were significantly lower in POD patients (WMD = −0.07; 95% CI −0.12 to −0.01; P = 0.026). Insufficient evidence was available to summarize the area under the curve (AUC) results.ConclusionsBlood lipid levels were significantly elevated in POD patients compared to NPOD patients. Hyperlipidemia was significantly associated with an increased risk of POD, highlighting its potential role as a risk factor.https://www.frontiersin.org/articles/10.3389/fnagi.2025.1544838/fullmeta-analysispostoperative deliriumhyperlipidemiashypertriglyceridemiahypercholesterolemia |
| spellingShingle | Li-quan Qiu Jian-li Song Li-cai Zhang Bin Fan Qiang Li Bin Lu Guan-yu Chen Association between hyperlipidemia and postoperative delirium risk: a systematic review and meta-analysis Frontiers in Aging Neuroscience meta-analysis postoperative delirium hyperlipidemias hypertriglyceridemia hypercholesterolemia |
| title | Association between hyperlipidemia and postoperative delirium risk: a systematic review and meta-analysis |
| title_full | Association between hyperlipidemia and postoperative delirium risk: a systematic review and meta-analysis |
| title_fullStr | Association between hyperlipidemia and postoperative delirium risk: a systematic review and meta-analysis |
| title_full_unstemmed | Association between hyperlipidemia and postoperative delirium risk: a systematic review and meta-analysis |
| title_short | Association between hyperlipidemia and postoperative delirium risk: a systematic review and meta-analysis |
| title_sort | association between hyperlipidemia and postoperative delirium risk a systematic review and meta analysis |
| topic | meta-analysis postoperative delirium hyperlipidemias hypertriglyceridemia hypercholesterolemia |
| url | https://www.frontiersin.org/articles/10.3389/fnagi.2025.1544838/full |
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