Different types of backward bifurcations due to density-dependent treatments

A set of deterministic SIS models with density-dependent treatments are studied to understand the disease dynamics when different treatment strategies are applied. Qualitative analyses are carried out in terms of general treatment functions. It has become customary that a backward bifurcation leads...

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Main Authors: Baojun Song, Wen Du, Jie Lou
Format: Article
Language:English
Published: AIMS Press 2013-07-01
Series:Mathematical Biosciences and Engineering
Subjects:
Online Access:https://www.aimspress.com/article/doi/10.3934/mbe.2013.10.1651
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author Baojun Song
Wen Du
Jie Lou
author_facet Baojun Song
Wen Du
Jie Lou
author_sort Baojun Song
collection DOAJ
description A set of deterministic SIS models with density-dependent treatments are studied to understand the disease dynamics when different treatment strategies are applied. Qualitative analyses are carried out in terms of general treatment functions. It has become customary that a backward bifurcation leads to bistable dynamics. However, this study finds that finds that bistability may not be an option at all; the disease-free equilibrium could be globally stable when there is a backward bifurcation. Furthermore, when a backward bifurcation occurs, the fashion of bistability could be the coexistence of either dual stable equilibria or the disease-free equilibrium and a stable limit cycle. We also extend the formula for mean infection period from density-independent treatments to density-dependent ones. Finally, the modeling results are applied to the transmission of gonorrhea in China, suggesting that these gonorrhea patients may not seek medical treatments in a timely manner.
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spelling doaj-art-05e032581764493989e248345b5253fd2025-01-24T02:26:34ZengAIMS PressMathematical Biosciences and Engineering1551-00182013-07-01105&61651166810.3934/mbe.2013.10.1651Different types of backward bifurcations due to density-dependent treatmentsBaojun Song0Wen Du1Jie Lou2Department of Mathematical Sciences, Montclair State University, Upper Montclair, NJ 07043Department of Mathematics, Shanghai University, 99 Shangda Road, Shanghai 200444Department of Mathematics, Shanghai University, 99 Shangda Road, Shanghai 200444A set of deterministic SIS models with density-dependent treatments are studied to understand the disease dynamics when different treatment strategies are applied. Qualitative analyses are carried out in terms of general treatment functions. It has become customary that a backward bifurcation leads to bistable dynamics. However, this study finds that finds that bistability may not be an option at all; the disease-free equilibrium could be globally stable when there is a backward bifurcation. Furthermore, when a backward bifurcation occurs, the fashion of bistability could be the coexistence of either dual stable equilibria or the disease-free equilibrium and a stable limit cycle. We also extend the formula for mean infection period from density-independent treatments to density-dependent ones. Finally, the modeling results are applied to the transmission of gonorrhea in China, suggesting that these gonorrhea patients may not seek medical treatments in a timely manner.https://www.aimspress.com/article/doi/10.3934/mbe.2013.10.1651density-dependentgonorrhea.treatmentbifurcation
spellingShingle Baojun Song
Wen Du
Jie Lou
Different types of backward bifurcations due to density-dependent treatments
Mathematical Biosciences and Engineering
density-dependent
gonorrhea.
treatment
bifurcation
title Different types of backward bifurcations due to density-dependent treatments
title_full Different types of backward bifurcations due to density-dependent treatments
title_fullStr Different types of backward bifurcations due to density-dependent treatments
title_full_unstemmed Different types of backward bifurcations due to density-dependent treatments
title_short Different types of backward bifurcations due to density-dependent treatments
title_sort different types of backward bifurcations due to density dependent treatments
topic density-dependent
gonorrhea.
treatment
bifurcation
url https://www.aimspress.com/article/doi/10.3934/mbe.2013.10.1651
work_keys_str_mv AT baojunsong differenttypesofbackwardbifurcationsduetodensitydependenttreatments
AT wendu differenttypesofbackwardbifurcationsduetodensitydependenttreatments
AT jielou differenttypesofbackwardbifurcationsduetodensitydependenttreatments