Association of Sweet's Syndrome and Systemic Lupus Erythematosus
Sweet's syndrome is an acute febrile neutrophilic dermatosis which usually presents as an idiopathic disorder but can also be drug induced, associated with hematopoetic malignancies and myelodysplastic disorders, and more, infrequently, observed in autoimmune disorders. Sweet's syndrome ha...
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| Format: | Article |
| Language: | English |
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Wiley
2011-01-01
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| Series: | Case Reports in Rheumatology |
| Online Access: | http://dx.doi.org/10.1155/2011/242681 |
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| author | J. L. Barton L. Pincus J. Yazdany N. Richman T. H. McCalmont L. Gensler M. Dall'Era K. H. Fye |
| author_facet | J. L. Barton L. Pincus J. Yazdany N. Richman T. H. McCalmont L. Gensler M. Dall'Era K. H. Fye |
| author_sort | J. L. Barton |
| collection | DOAJ |
| description | Sweet's syndrome is an acute febrile neutrophilic dermatosis which usually presents as an idiopathic disorder but can also be drug induced, associated with hematopoetic malignancies and myelodysplastic disorders, and more, infrequently, observed in autoimmune disorders. Sweet's syndrome has been reported in three cases of neonatal lupus, three cases of hydralazine-induced lupus in adults, and in nine pediatric and adult systemic lupus erythematosus (SLE) patients. We describe three additional adult cases of Sweet's associated with SLE and provide a focused review on nondrug-induced, nonneonatal SLE and Sweet's. In two of three new cases, as in the majority of prior cases, the skin rash of Sweet's paralleled underlying SLE disease activity. The pathogenesis of Sweet's remains elusive, but evidence suggests that cytokine dysregulation may be central to the clinical and pathological changes in this condition, as well as in SLE. Further research is needed to define the exact relationship between the two conditions. |
| format | Article |
| id | doaj-art-05ddf84fdabe4c178118d80fb41d0746 |
| institution | Kabale University |
| issn | 2090-6889 2090-6897 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Rheumatology |
| spelling | doaj-art-05ddf84fdabe4c178118d80fb41d07462025-08-20T03:54:16ZengWileyCase Reports in Rheumatology2090-68892090-68972011-01-01201110.1155/2011/242681242681Association of Sweet's Syndrome and Systemic Lupus ErythematosusJ. L. Barton0L. Pincus1J. Yazdany2N. Richman3T. H. McCalmont4L. Gensler5M. Dall'Era6K. H. Fye7Division of Rheumatology, Department of Medicine, University of California, San Francisco, CA 94143, USADivision of Rheumatology, Department of Medicine, University of California, San Francisco, CA 94143, USADivision of Rheumatology, Department of Medicine, University of California, San Francisco, CA 94143, USADivision of Rheumatology, Department of Medicine, University of California, San Francisco, CA 94143, USADivision of Rheumatology, Department of Medicine, University of California, San Francisco, CA 94143, USADivision of Rheumatology, Department of Medicine, University of California, San Francisco, CA 94143, USADivision of Rheumatology, Department of Medicine, University of California, San Francisco, CA 94143, USADivision of Rheumatology, Department of Medicine, University of California, San Francisco, CA 94143, USASweet's syndrome is an acute febrile neutrophilic dermatosis which usually presents as an idiopathic disorder but can also be drug induced, associated with hematopoetic malignancies and myelodysplastic disorders, and more, infrequently, observed in autoimmune disorders. Sweet's syndrome has been reported in three cases of neonatal lupus, three cases of hydralazine-induced lupus in adults, and in nine pediatric and adult systemic lupus erythematosus (SLE) patients. We describe three additional adult cases of Sweet's associated with SLE and provide a focused review on nondrug-induced, nonneonatal SLE and Sweet's. In two of three new cases, as in the majority of prior cases, the skin rash of Sweet's paralleled underlying SLE disease activity. The pathogenesis of Sweet's remains elusive, but evidence suggests that cytokine dysregulation may be central to the clinical and pathological changes in this condition, as well as in SLE. Further research is needed to define the exact relationship between the two conditions.http://dx.doi.org/10.1155/2011/242681 |
| spellingShingle | J. L. Barton L. Pincus J. Yazdany N. Richman T. H. McCalmont L. Gensler M. Dall'Era K. H. Fye Association of Sweet's Syndrome and Systemic Lupus Erythematosus Case Reports in Rheumatology |
| title | Association of Sweet's Syndrome and Systemic Lupus Erythematosus |
| title_full | Association of Sweet's Syndrome and Systemic Lupus Erythematosus |
| title_fullStr | Association of Sweet's Syndrome and Systemic Lupus Erythematosus |
| title_full_unstemmed | Association of Sweet's Syndrome and Systemic Lupus Erythematosus |
| title_short | Association of Sweet's Syndrome and Systemic Lupus Erythematosus |
| title_sort | association of sweet s syndrome and systemic lupus erythematosus |
| url | http://dx.doi.org/10.1155/2011/242681 |
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