LINE-1 transposition into murine Thyroglobulin results in congenital thyroid dysplasia.

LINE-1 transposition into murine Thyroglobulin results in congenital thyroid dysplasia.

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A spontaneous mutation in the wild type C57BL/6NTac mouse was discovered that is associated with early-onset histopathologic sequalae typical of thyroid dysplasia. The spontaneous mutation resulted from insertion of a L1 long interspersed nuclear element (LINE-1) into an intron within the Thyroglobu...

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Main Authors: Wendy J Bailey, Bart M G Smits, Zoltan Erdos, John M Gaspar, Pamela Lane, Sabu Kuruvilla, Thomas W Rosahl, Douglas Thudium, Jingzhou Wang, Warren E Glaab, Melissa MacGowan, Heather Multari, Christine Cumo, Adam Navis, Thomas Forest
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2025-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0325493
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