Glutamine Supplementation in Sick Children: Is It Beneficial?
The purpose of this review is to provide a critical appraisal of the literature on Glutamine (Gln) supplementation in various conditions or illnesses that affect children, from neonates to adolescents. First, a general overview of the proposed mechanisms for the beneficial effects of Gln is provided...
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| Format: | Article |
| Language: | English |
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Wiley
2011-01-01
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| Series: | Journal of Nutrition and Metabolism |
| Online Access: | http://dx.doi.org/10.1155/2011/617597 |
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| _version_ | 1832558772562690048 |
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| author | Elise Mok Régis Hankard |
| author_facet | Elise Mok Régis Hankard |
| author_sort | Elise Mok |
| collection | DOAJ |
| description | The purpose of this review is to provide a critical appraisal of the literature on Glutamine (Gln) supplementation in various conditions or illnesses that affect children, from neonates to adolescents. First, a general overview of the proposed mechanisms for the beneficial effects of Gln is provided, and subsequently clinical studies are discussed. Despite safety, studies are conflicting, partly due to different effects of enteral and parenteral Gln supplementation. Further insufficient evidence is available on the benefits of Gln supplementation in pediatric patients. This includes premature infants, infants with gastrointestinal disease, children with Crohn's disease, short bowel syndrome, malnutrition/diarrhea, cancer, severe burns/trauma, Duchenne muscular dystrophy, sickle cell anemia, cystic fibrosis, and type 1 diabetes. Moreover, methodological issues have been noted in some studies. Further mechanistic data is needed along with large randomized controlled trials in select populations of sick children, who may eventually benefit from supplemental Gln. |
| format | Article |
| id | doaj-art-05d6a172f1084c89854f9f88d508414b |
| institution | Kabale University |
| issn | 2090-0724 2090-0732 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Nutrition and Metabolism |
| spelling | doaj-art-05d6a172f1084c89854f9f88d508414b2025-02-03T01:31:35ZengWileyJournal of Nutrition and Metabolism2090-07242090-07322011-01-01201110.1155/2011/617597617597Glutamine Supplementation in Sick Children: Is It Beneficial?Elise Mok0Régis Hankard1INSERM Centre D'Investigation Clinique 802, Centre Hospitalier Universitaire de Poitiers, 86021 Poitiers Cedex, FranceINSERM Centre D'Investigation Clinique 802, Centre Hospitalier Universitaire de Poitiers, 86021 Poitiers Cedex, FranceThe purpose of this review is to provide a critical appraisal of the literature on Glutamine (Gln) supplementation in various conditions or illnesses that affect children, from neonates to adolescents. First, a general overview of the proposed mechanisms for the beneficial effects of Gln is provided, and subsequently clinical studies are discussed. Despite safety, studies are conflicting, partly due to different effects of enteral and parenteral Gln supplementation. Further insufficient evidence is available on the benefits of Gln supplementation in pediatric patients. This includes premature infants, infants with gastrointestinal disease, children with Crohn's disease, short bowel syndrome, malnutrition/diarrhea, cancer, severe burns/trauma, Duchenne muscular dystrophy, sickle cell anemia, cystic fibrosis, and type 1 diabetes. Moreover, methodological issues have been noted in some studies. Further mechanistic data is needed along with large randomized controlled trials in select populations of sick children, who may eventually benefit from supplemental Gln.http://dx.doi.org/10.1155/2011/617597 |
| spellingShingle | Elise Mok Régis Hankard Glutamine Supplementation in Sick Children: Is It Beneficial? Journal of Nutrition and Metabolism |
| title | Glutamine Supplementation in Sick Children: Is It Beneficial? |
| title_full | Glutamine Supplementation in Sick Children: Is It Beneficial? |
| title_fullStr | Glutamine Supplementation in Sick Children: Is It Beneficial? |
| title_full_unstemmed | Glutamine Supplementation in Sick Children: Is It Beneficial? |
| title_short | Glutamine Supplementation in Sick Children: Is It Beneficial? |
| title_sort | glutamine supplementation in sick children is it beneficial |
| url | http://dx.doi.org/10.1155/2011/617597 |
| work_keys_str_mv | AT elisemok glutaminesupplementationinsickchildrenisitbeneficial AT regishankard glutaminesupplementationinsickchildrenisitbeneficial |