OXIDATIVE STRESS AND HISTOLOGICAL CHANGES INDUCED BY THE NANO-Fe2O3 IN HELIX ASPERSA
everal studies show that nanoparticles (NPs) can penetrate the body through several routes and have systemic toxic effects on human health. This study aims to provide answers to the understanding of the nature and origin of the biological effects of NPs of metal oxide: Fe2O3 on a bioaccumulator and...
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Alma Mater Publishing House "Vasile Alecsandri" University of Bacau
2019-06-01
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| Series: | Scientific Study & Research: Chemistry & Chemical Engineering, Biotechnology, Food Industry |
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| Online Access: | http://pubs.ub.ro/?pg=revues&rev=cscc6&num=201902&vol=2&aid=4910 |
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| author | SAMIRA BENSOLTANE MOHAMED DJEKOUN |
| author_facet | SAMIRA BENSOLTANE MOHAMED DJEKOUN |
| author_sort | SAMIRA BENSOLTANE |
| collection | DOAJ |
| description | everal studies show that nanoparticles (NPs) can penetrate the body through several routes and have systemic toxic effects on human health. This study aims to provide answers to the understanding of the nature and origin of the biological effects of NPs of metal oxide: Fe2O3 on a bioaccumulator and bioindicator species, the terrestrial snail Helix aspersa. Their effects were studied on snail adults by a laboratory-focused approach, and we evaluated the effect of three doses of these nanoparticles (1, 2 and 3 mg∙g-1 of food) in wheat flour for six weeks; the control group receives only flour alone. At the end of the treatment, we measured the levels of antioxidant enzymatic defences: glutathione (GSH), glutathione-S-transferase (GST), glutathione-peroxydase (GPx), malondialdehyde (MDA), catalase (CAT), and histological sections at the kidney level of each group were performed. Our results reveal triggered oxidative stress and an induction of the detoxification system, with an increase in GSH, GST, GPx and MDA levels with a decrease in catalase activity. Very clear renal tissue damage confirms the results obtained at the beginning dosages. |
| format | Article |
| id | doaj-art-05d6796bda524488bea1a9dbaef3f308 |
| institution | DOAJ |
| issn | 1582-540X 1582-540X |
| language | English |
| publishDate | 2019-06-01 |
| publisher | Alma Mater Publishing House "Vasile Alecsandri" University of Bacau |
| record_format | Article |
| series | Scientific Study & Research: Chemistry & Chemical Engineering, Biotechnology, Food Industry |
| spelling | doaj-art-05d6796bda524488bea1a9dbaef3f3082025-08-20T03:16:39ZengAlma Mater Publishing House "Vasile Alecsandri" University of BacauScientific Study & Research: Chemistry & Chemical Engineering, Biotechnology, Food Industry1582-540X1582-540X2019-06-01202119133OXIDATIVE STRESS AND HISTOLOGICAL CHANGES INDUCED BY THE NANO-Fe2O3 IN HELIX ASPERSASAMIRA BENSOLTANE0MOHAMED DJEKOUN 1 University Badji Mokhtar, Faculty of Sciences, Department of Biology, B.P. 12, Sidi-Ammar 23000, Annaba, Algeria & University Badji Mokhtar, Faculty of Medicine, Department of Dental Medicine, 23000, Annaba, AlgeriaUniversity of 08 May 1945 Guelma, Faculty Sciences of Nature and of Life and Sciences of the Earth and the Universe, 24000, Guelma, Algeriaeveral studies show that nanoparticles (NPs) can penetrate the body through several routes and have systemic toxic effects on human health. This study aims to provide answers to the understanding of the nature and origin of the biological effects of NPs of metal oxide: Fe2O3 on a bioaccumulator and bioindicator species, the terrestrial snail Helix aspersa. Their effects were studied on snail adults by a laboratory-focused approach, and we evaluated the effect of three doses of these nanoparticles (1, 2 and 3 mg∙g-1 of food) in wheat flour for six weeks; the control group receives only flour alone. At the end of the treatment, we measured the levels of antioxidant enzymatic defences: glutathione (GSH), glutathione-S-transferase (GST), glutathione-peroxydase (GPx), malondialdehyde (MDA), catalase (CAT), and histological sections at the kidney level of each group were performed. Our results reveal triggered oxidative stress and an induction of the detoxification system, with an increase in GSH, GST, GPx and MDA levels with a decrease in catalase activity. Very clear renal tissue damage confirms the results obtained at the beginning dosages.http://pubs.ub.ro/?pg=revues&rev=cscc6&num=201902&vol=2&aid=4910Helix aspersahistologicaliron oxide "Fe2O3"kidneynanoparticlesoxidative stress |
| spellingShingle | SAMIRA BENSOLTANE MOHAMED DJEKOUN OXIDATIVE STRESS AND HISTOLOGICAL CHANGES INDUCED BY THE NANO-Fe2O3 IN HELIX ASPERSA Scientific Study & Research: Chemistry & Chemical Engineering, Biotechnology, Food Industry Helix aspersa histological iron oxide "Fe2O3" kidney nanoparticles oxidative stress |
| title | OXIDATIVE STRESS AND HISTOLOGICAL CHANGES INDUCED BY THE NANO-Fe2O3 IN HELIX ASPERSA |
| title_full | OXIDATIVE STRESS AND HISTOLOGICAL CHANGES INDUCED BY THE NANO-Fe2O3 IN HELIX ASPERSA |
| title_fullStr | OXIDATIVE STRESS AND HISTOLOGICAL CHANGES INDUCED BY THE NANO-Fe2O3 IN HELIX ASPERSA |
| title_full_unstemmed | OXIDATIVE STRESS AND HISTOLOGICAL CHANGES INDUCED BY THE NANO-Fe2O3 IN HELIX ASPERSA |
| title_short | OXIDATIVE STRESS AND HISTOLOGICAL CHANGES INDUCED BY THE NANO-Fe2O3 IN HELIX ASPERSA |
| title_sort | oxidative stress and histological changes induced by the nano fe2o3 in helix aspersa |
| topic | Helix aspersa histological iron oxide "Fe2O3" kidney nanoparticles oxidative stress |
| url | http://pubs.ub.ro/?pg=revues&rev=cscc6&num=201902&vol=2&aid=4910 |
| work_keys_str_mv | AT samirabensoltane oxidativestressandhistologicalchangesinducedbythenanofe2o3inhelixaspersa AT mohameddjekoun oxidativestressandhistologicalchangesinducedbythenanofe2o3inhelixaspersa |