Association between NFKB1 −94ins/del ATTG Promoter Polymorphism and Cancer Susceptibility: An Updated Meta-Analysis
Nuclear factor-κB is associated with the pathogenesis of numerous malignancies, and the functional polymorphism −94ins/del ATTG (rs28362491) in the human NFKB1 gene is associated with cancer risk. Previous studies on the association between the −94ins/del ATTG polymorphism and cancer risk reported c...
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | International Journal of Genomics |
| Online Access: | http://dx.doi.org/10.1155/2014/612972 |
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| author | Xiao Yang Pengchao Li Jun Tao Chao Qin Qiang Cao Jinbao Gu Xiaheng Deng Jun Wang Xuzhong Liu Zijie Wang Bian Wu Min Gu Qiang Lu Changjun Yin |
| author_facet | Xiao Yang Pengchao Li Jun Tao Chao Qin Qiang Cao Jinbao Gu Xiaheng Deng Jun Wang Xuzhong Liu Zijie Wang Bian Wu Min Gu Qiang Lu Changjun Yin |
| author_sort | Xiao Yang |
| collection | DOAJ |
| description | Nuclear factor-κB is associated with the pathogenesis of numerous malignancies, and the functional polymorphism −94ins/del ATTG (rs28362491) in the human NFKB1 gene is associated with cancer risk. Previous studies on the association between the −94ins/del ATTG polymorphism and cancer risk reported conflicting results. To clarify this relationship, we performed a meta-analysis of 21 case-control studies involving 6127 cases and 9238 controls. We used pooled odds ratios (ORs) with their 95% confidence intervals (95% CIs) to assess the association. We found that the NFKB1 promoter −94ins/del ATTG polymorphism was significantly associated with cancer risk in four genetic models (ins/ins versus del/del, OR = 1.47, 95% CI = 1.11–1.93; dominant model, OR = 1.26, 95% CI = 1.03–1.53; recessive model, OR = 1.26, 95% CI = 1.05–1.51; ins allele versus del allele, OR = 1.19, 95% CI = 1.05–1.35). Stratified analyses revealed a significant association between the polymorphism and ovarian, oral, and prostate cancers. Similar results were determined in an Asian population and not in a Caucasian population. Thus, our results suggested that the polymorphism can contribute to cancer risk. Moreover, the polymorphism can exert race- and cancer-specific effects on cancer risk. Further large-scale and functional studies are necessary to elucidate this possible effect. |
| format | Article |
| id | doaj-art-05d4373461214c309df474baa6dc2236 |
| institution | Kabale University |
| issn | 2314-436X 2314-4378 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Genomics |
| spelling | doaj-art-05d4373461214c309df474baa6dc22362025-02-03T06:07:55ZengWileyInternational Journal of Genomics2314-436X2314-43782014-01-01201410.1155/2014/612972612972Association between NFKB1 −94ins/del ATTG Promoter Polymorphism and Cancer Susceptibility: An Updated Meta-AnalysisXiao Yang0Pengchao Li1Jun Tao2Chao Qin3Qiang Cao4Jinbao Gu5Xiaheng Deng6Jun Wang7Xuzhong Liu8Zijie Wang9Bian Wu10Min Gu11Qiang Lu12Changjun Yin13Department of Urology, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, ChinaDepartment of Urology, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, ChinaDepartment of Urology, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, ChinaDepartment of Urology, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, ChinaDepartment of Urology, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, ChinaDepartment of Urology, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, ChinaDepartment of Urology, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, ChinaDepartment of Urology, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, ChinaDepartment of Urology, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, ChinaDepartment of Urology, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, ChinaDepartment of Urology, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, ChinaDepartment of Urology, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, ChinaDepartment of Urology, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, ChinaDepartment of Urology, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, ChinaNuclear factor-κB is associated with the pathogenesis of numerous malignancies, and the functional polymorphism −94ins/del ATTG (rs28362491) in the human NFKB1 gene is associated with cancer risk. Previous studies on the association between the −94ins/del ATTG polymorphism and cancer risk reported conflicting results. To clarify this relationship, we performed a meta-analysis of 21 case-control studies involving 6127 cases and 9238 controls. We used pooled odds ratios (ORs) with their 95% confidence intervals (95% CIs) to assess the association. We found that the NFKB1 promoter −94ins/del ATTG polymorphism was significantly associated with cancer risk in four genetic models (ins/ins versus del/del, OR = 1.47, 95% CI = 1.11–1.93; dominant model, OR = 1.26, 95% CI = 1.03–1.53; recessive model, OR = 1.26, 95% CI = 1.05–1.51; ins allele versus del allele, OR = 1.19, 95% CI = 1.05–1.35). Stratified analyses revealed a significant association between the polymorphism and ovarian, oral, and prostate cancers. Similar results were determined in an Asian population and not in a Caucasian population. Thus, our results suggested that the polymorphism can contribute to cancer risk. Moreover, the polymorphism can exert race- and cancer-specific effects on cancer risk. Further large-scale and functional studies are necessary to elucidate this possible effect.http://dx.doi.org/10.1155/2014/612972 |
| spellingShingle | Xiao Yang Pengchao Li Jun Tao Chao Qin Qiang Cao Jinbao Gu Xiaheng Deng Jun Wang Xuzhong Liu Zijie Wang Bian Wu Min Gu Qiang Lu Changjun Yin Association between NFKB1 −94ins/del ATTG Promoter Polymorphism and Cancer Susceptibility: An Updated Meta-Analysis International Journal of Genomics |
| title | Association between NFKB1 −94ins/del ATTG Promoter Polymorphism and Cancer Susceptibility: An Updated Meta-Analysis |
| title_full | Association between NFKB1 −94ins/del ATTG Promoter Polymorphism and Cancer Susceptibility: An Updated Meta-Analysis |
| title_fullStr | Association between NFKB1 −94ins/del ATTG Promoter Polymorphism and Cancer Susceptibility: An Updated Meta-Analysis |
| title_full_unstemmed | Association between NFKB1 −94ins/del ATTG Promoter Polymorphism and Cancer Susceptibility: An Updated Meta-Analysis |
| title_short | Association between NFKB1 −94ins/del ATTG Promoter Polymorphism and Cancer Susceptibility: An Updated Meta-Analysis |
| title_sort | association between nfkb1 94ins del attg promoter polymorphism and cancer susceptibility an updated meta analysis |
| url | http://dx.doi.org/10.1155/2014/612972 |
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